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Query: SEMA4D

RNAi screen result RNAPII IP (PI) CSB IP CSB IP (PI) Chrom. Chrom. (PI) Phosphorylation Ubiquitylation
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[Click on the plots to view the data selection in the respective scatterplot]

Protein Results:

 Results for post-translational modifications: see below | Red/green: hit at lower/upper end of the respective screen
Gene name Point score Z-score sums RNAi high RNAi low RNAPII-IP (PI) CSB-IP CSB-IP (PI) Chrom. Chrom. (PI)
SEMA4D 0 2.908 -0.540 0.790
SEMA4D 0 2.908 0.260 -0.350

PTM Sites:

 Back to Protein Results | Red/green: hit at lower/upper end of the respective screen
Gene name PTM type PTM site UV UV (PI) Sequence
SEMA4D Ubiquitylation K784 0.913 1.205 _SALLIGKK(gl)_
SEMA4D Ubiquitylation K857 0.832 _DKPFDVK(gl)CELK_

Background Information for SEMA4D:


Pubmed-SEMA4D »
Uniprot-SEMA4D »
Biogrid-SEMA4D »
ProteomicsDB-SEMA4D »

Tumorportal-SEMA4D »
COSMIC-SEMA4D »
GenomeRNAi-SEMA4D »
Genecards-SEMA4D


Protein-protein Interactions for SEMA4D
Show screen data for Category Name and Description Link to cat description Data Source
Category members IP bait SCGB1D1 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait SCGB2A2 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait ST8SIA4 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait VCAM1 Cat. description BioPlex, Huttlin, Gygi, Cell 2015


Protein Domains in SEMA4D
Domain name Domain Description TC-NER relevance -log10(p-value)
Category members Ig-like_dom IPR007110 0.6
Category members Ig_sub IPR003599 0.43
Category members Immunoglobulin IPR013151 0.23
Category members Ig_sub2 IPR003598 0.21
Category members Semap_dom IPR001627 0.04
Category members Plexin_repeat IPR002165 0
Category members Plexin-like_fold IPR016201 0


Protein complexes (CORUM database) featuring SEMA4D
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)


Categories featuring SEMA4D
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)
Category members GO Category GO:0005515 protein binding Database INF
Category members GO Category GO:0005615 extracellular space Database 4.72
Category members GO Category GO:0005887 integral to plasma membrane Database 1.69
Category members GO Category GO:0006955 immune response Database 1.22
Category members GO Category GO:0005886 plasma membrane Database 1.21
Category members Pathway Pathway_673 REACTOME_AXON_GUIDANCE 0 1.06
Category members Pathway Pathway_674 REACTOME_SEMAPHORIN_INTERACTIONS 0 0.96
Category members GO Category GO:0043066 negative regulation of apoptotic process Database 0.6
Category members GO Category GO:0016020 membrane Database 0.52
Category members Pathway Pathway_42 REACTOME_DEVELOPMENTAL_BIOLOGY 0 0.32
Category members GO Category GO:0007275 multicellular organismal development Database 0.31
Category members GO Category GO:0045668 negative regulation of osteoblast differentiation Database 0.29
Category members GO Category GO:0001934 positive regulation of protein phosphorylation Database 0.22
Category members GO Category GO:0004888 transmembrane signaling receptor activity Database 0.15
Category members GO Category GO:0007411 axon guidance Database 0.13
Category members Pathway Pathway_1034 KEGG_AXON_GUIDANCE 0 0.04
Category members GO Category GO:0000122 negative regulation of transcription from RNA polymerase II promoter Database 0.02
Category members GO Category GO:0050732 negative regulation of peptidyl-tyrosine phosphorylation Database 0
Category members Pathway Pathway_1032 REACTOME_SEMA4D_IN_SEMAPHORIN_SIGNALING 0 0
Category members Pathway Pathway_1035 REACTOME_SEMA4D_INDUCED_CELL_MIGRATION_AND_GROWTH_CONE_COLLAPSE 0 0
Category members GO Category GO:0004872 receptor activity Database 0
Category members GO Category GO:0005102 receptor binding Database 0
Category members GO Category GO:0007155 cell adhesion Database 0
Category members GO Category GO:0008360 regulation of cell shape Database 0
Category members GO Category GO:0010693 negative regulation of alkaline phosphatase activity Database 0
Category members GO Category GO:0014068 positive regulation of phosphatidylinositol 3-kinase signaling Database 0
Category members GO Category GO:0030215 semaphorin receptor binding Database 0
Category members GO Category GO:0030335 positive regulation of cell migration Database 0
Category members GO Category GO:0031344 regulation of cell projection organization Database 0
Category members GO Category GO:0032321 positive regulation of Rho GTPase activity Database 0
Category members GO Category GO:0043931 ossification involved in bone maturation Database 0
Category members GO Category GO:0048672 positive regulation of collateral sprouting Database 0
Category members GO Category GO:0048814 regulation of dendrite morphogenesis Database 0
Category members GO Category GO:0050731 positive regulation of peptidyl-tyrosine phosphorylation Database 0
Category members GO Category GO:0050772 positive regulation of axonogenesis Database 0


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