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Query: PVRL2

RNAi screen result RNAPII IP (PI) CSB IP CSB IP (PI) Chrom. Chrom. (PI) Phosphorylation Ubiquitylation
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[Click on the plots to view the data selection in the respective scatterplot]

Protein Results:

 Results for post-translational modifications: see below | Red/green: hit at lower/upper end of the respective screen
Gene name Point score Z-score sums RNAi high RNAi low RNAPII-IP (PI) CSB-IP CSB-IP (PI) Chrom. Chrom. (PI)
PVRL2 0 2.365 -0.940 1.620 0.748 -0.029

PTM Sites:

 Back to Protein Results | Red/green: hit at lower/upper end of the respective screen
Gene name PTM type PTM site UV UV (PI) Sequence
PVRL2 Phosphorylation S430 0.026 _LEAQEMPSQLFTLGAS(ph)EHSPLK_
PVRL2 Phosphorylation S433 -0.325 _LEAQEMPSQLFTLGASEHS(ph)PLK_
PVRL2 Phosphorylation T410 -1.005 _EQTLQGAEEDEDLEGPPSYKPPT(ph)PK_

Background Information for PVRL2:


Pubmed-PVRL2 »
Uniprot-PVRL2 »
Biogrid-PVRL2 »
ProteomicsDB-PVRL2 »

Tumorportal-PVRL2 »
COSMIC-PVRL2 »
GenomeRNAi-PVRL2 »
Genecards-PVRL2


Protein-protein Interactions for PVRL2
Show screen data for Category Name and Description Link to cat description Data Source
Category members IP bait APOD Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait PANK2 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait PICK1 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait PVRL2 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait PVRL3 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait RARS Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait SYPL2 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait TBC1D22A Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait TMEM30B Cat. description BioPlex, Huttlin, Gygi, Cell 2015


Protein Domains in PVRL2
Domain name Domain Description TC-NER relevance -log10(p-value)
Category members Ig-like_dom IPR007110 0.6
Category members Ig_sub IPR003599 0.43
Category members Immunoglobulin IPR013151 0.23
Category members Ig_V-set IPR013106 0.09
Category members Ig_V-set_subgr IPR003596 0
Category members CD80_C2-set IPR013162 0


Protein complexes (CORUM database) featuring PVRL2
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)


Categories featuring PVRL2
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)
Category members GO Category GO:0005515 protein binding Database INF
Category members GO Category GO:0019048 modulation by virus of host morphology or physiology Database 7.81
Category members GO Category GO:0016021 integral to membrane Database 7.67
Category members Pathway Pathway_621 REACTOME_ADAPTIVE_IMMUNE_SYSTEM 0 4.72
Category members Pathway Pathway_458 REACTOME_IMMUNE_SYSTEM 0 3
Category members Pathway Pathway_466 PID_ECADHERIN_STABILIZATION_PATHWAY 0 1.4
Category members GO Category GO:0005911 cell-cell junction Database 1.4
Category members GO Category GO:0005886 plasma membrane Database 1.21
Category members GO Category GO:0005915 zonula adherens Database 0.93
Category members GO Category GO:0001618 virus receptor activity Database 0.83
Category members Pathway Pathway_747 KEGG_ADHERENS_JUNCTION 0 0.43
Category members GO Category GO:0034329 cell junction assembly Database 0.29
Category members GO Category GO:0007156 homophilic cell adhesion Database 0.28
Category members Pathway Pathway_560 REACTOME_CELL_CELL_COMMUNICATION 0 0.25
Category members Pathway Pathway_581 PID_NECTIN_PATHWAY 0 0.21
Category members GO Category GO:0051856 adhesion to symbiont Database 0.21
Category members GO Category GO:0007289 spermatid nucleus differentiation Database 0.18
Category members GO Category GO:0009986 cell surface Database 0.17
Category members GO Category GO:0033005 positive regulation of mast cell activation Database 0.13
Category members GO Category GO:0002891 positive regulation of immunoglobulin mediated immune response Database 0.11
Category members GO Category GO:0045216 cell-cell junction organization Database 0.1
Category members GO Category GO:0015026 coreceptor activity Database 0.07
Category members GO Category GO:0001675 acrosome assembly Database 0.02
Category members Pathway Pathway_1217 KEGG_CELL_ADHESION_MOLECULES_CAMS 0 0
Category members Pathway Pathway_1218 REACTOME_IMMUNOREGULATORY_INTERACTIONS_BETWEEN_A_LYMPHOID_AND_A_NON_LYMPHOID_CELL 0 0
Category members Pathway Pathway_1237 REACTOME_CELL_CELL_JUNCTION_ORGANIZATION 0 0
Category members Pathway Pathway_1276 REACTOME_ADHERENS_JUNCTIONS_INTERACTIONS 0 0
Category members Pathway Pathway_925 REACTOME_CELL_JUNCTION_ORGANIZATION 0 0
Category members GO Category GO:0002860 positive regulation of natural killer cell mediated cytotoxicity directed against tumor cell target Database 0
Category members GO Category GO:0007010 cytoskeleton organization Database 0
Category members GO Category GO:0007286 spermatid development Database 0
Category members GO Category GO:0009566 fertilization Database 0
Category members GO Category GO:0019064 fusion of virus membrane with host plasma membrane Database 0
Category members GO Category GO:0034332 adherens junction organization Database 0
Category members GO Category GO:0042271 susceptibility to natural killer cell mediated cytotoxicity Database 0
Category members GO Category GO:0042803 protein homodimerization activity Database 0
Category members GO Category GO:0044782 cilium organization Database 0
Category members GO Category GO:0045954 positive regulation of natural killer cell mediated cytotoxicity Database 0
Category members GO Category GO:0050776 regulation of immune response Database 0
Category members GO Category GO:0050839 cell adhesion molecule binding Database 0
Category members GO Category GO:0051654 establishment of mitochondrion localization Database 0
Category members GO Category GO:0060370 susceptibility to T cell mediated cytotoxicity Database 0


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