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bioLOGIC Data

Query: PSMD14

RNAi screen result	RNAPII IP (PI)	CSB IP	CSB IP (PI)	Chrom.	Chrom. (PI)	Phosphorylation	Ubiquitylation
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[Click on the plots to view the data selection in the respective scatterplot]

Protein Results:
Results for post-translational modifications: see below | Red/green: hit at lower/upper end of the respective screen

Gene name	Point score	Z-score sums	RNAi high	RNAi low	RNAPII-IP (PI)	CSB-IP	CSB-IP (PI)	Chrom.	Chrom. (PI)
PSMD14	0	-0.149			-0.108	-0.655	0.117	-0.121	-0.010

PTM Sites:
Back to Protein Results | Red/green: hit at lower/upper end of the respective screen

Gene name	PTM type	PTM site	UV	UV (PI)	Sequence
PSMD14	Ubiquitylation	K154	-1.127	0.434	_GK(gl)VVIDAFR_
PSMD14	Ubiquitylation	K253	0.194	-0.255	_EMLELAK(gl)NYNK_
PSMD14	Ubiquitylation	K257	-0.581	-0.994	_NYNK(gl)AVEEEDKMTPEQLAIK_

Background Information for PSMD14:

Pubmed-PSMD14 »

Uniprot-PSMD14 »

Biogrid-PSMD14 »

ProteomicsDB-PSMD14 »

Tumorportal-PSMD14 »

COSMIC-PSMD14 »

GenomeRNAi-PSMD14 »

Genecards-PSMD14

Protein-protein Interactions for PSMD14

Show screen data for	Category Name and Description	Link to cat description	Data Source
Category members	IP bait PSMB4	Cat. description	Hein, Mann, Cell 2015
Category members	IP bait PSMB5	Cat. description	Hein, Mann, Cell 2015
Category members	IP bait PSMC1	Cat. description	Hein, Mann, Cell 2015
Category members	IP bait PSMD14	Cat. description	Hein, Mann, Cell 2015
Category members	IP bait PSMD6	Cat. description	Hein, Mann, Cell 2015
Category members	IP bait ADRM1	Cat. description	BioPlex, Huttlin, Gygi, Cell 2015
Category members	IP bait CCDC74B	Cat. description	BioPlex, Huttlin, Gygi, Cell 2015
Category members	IP bait CCDC92	Cat. description	BioPlex, Huttlin, Gygi, Cell 2015
Category members	IP bait PSMB3	Cat. description	BioPlex, Huttlin, Gygi, Cell 2015
Category members	IP bait PSMB9	Cat. description	BioPlex, Huttlin, Gygi, Cell 2015
Category members	IP bait PSMC5	Cat. description	BioPlex, Huttlin, Gygi, Cell 2015
Category members	IP bait PSMD12	Cat. description	BioPlex, Huttlin, Gygi, Cell 2015
Category members	IP bait PSMD7	Cat. description	BioPlex, Huttlin, Gygi, Cell 2015
Category members	IP bait UCHL5	Cat. description	BioPlex, Huttlin, Gygi, Cell 2015

Protein Domains in PSMD14

	Domain name	Domain Description	TC-NER relevance -log10(p-value)
Category members	JAMM/MPN+_dom	IPR000555	1.33

Protein complexes (CORUM database) featuring PSMD14

	Category Type	Category ID	Category Name	Data Source	TC-NER relevance -log10(p-value)
Category members	Corum	32	PA700 complex	Database	1.8
Category members	Corum	193	PA700-20S-PA28 complex	Database	0.98

Categories featuring PSMD14

	Category Type	Category ID	Category Name	Data Source	TC-NER relevance -log10(p-value)
Category members	Pathway	Pathway_771	REACTOME_METABOLISM_OF_RNA	0	INF
Category members	Pathway	Pathway_773	REACTOME_METABOLISM_OF_MRNA	0	INF
Category members	GO Category	GO:0005515	protein binding	Database	INF
Category members	GO Category	GO:0005654	nucleoplasm	Database	INF
Category members	GO Category	GO:0005829	cytosol	Database	INF
Category members	GO Category	GO:0010467	gene expression	Database	INF
Category members	GO Category	GO:0016032	viral process	Database	INF
Category members	GO Category	GO:0016070	RNA metabolic process	Database	INF
Category members	GO Category	GO:0016071	mRNA metabolic process	Database	INF
Category members	Pathway	Pathway_197	REACTOME_HIV_INFECTION	0	12.07
Category members	Pathway	Pathway_320	REACTOME_CELL_CYCLE	0	11.08
Category members	GO Category	GO:0000278	mitotic cell cycle	Database	10.63
Category members	Pathway	Pathway_196	REACTOME_HOST_INTERACTIONS_OF_HIV_FACTORS	0	9.67
Category members	Pathway	Pathway_321	REACTOME_MITOTIC_M_M_G1_PHASES	0	5.47
Category members	Pathway	Pathway_323	REACTOME_DNA_REPLICATION	0	5.24
Category members	Pathway	Pathway_317	REACTOME_CELL_CYCLE_MITOTIC	0	4.82
Category members	Pathway	Pathway_621	REACTOME_ADAPTIVE_IMMUNE_SYSTEM	0	4.72
Category members	Pathway	Pathway_790	REACTOME_CELL_CYCLE_CHECKPOINTS	0	3.89
Category members	GO Category	GO:0006511	ubiquitin-dependent protein catabolic process	Database	3.57
Category members	GO Category	GO:0051437	positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle	Database	3.38
Category members	GO Category	GO:0051436	negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle	Database	3.35
Category members	GO Category	GO:0051439	regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle	Database	3.26
Category members	GO Category	GO:0000502	proteasome complex	Database	3.17
Category members	Pathway	Pathway_827	REACTOME_AUTODEGRADATION_OF_CDH1_BY_CDH1_APC_C	0	3.01
Category members	Pathway	Pathway_458	REACTOME_IMMUNE_SYSTEM	0	3
Category members	Pathway	Pathway_765	REACTOME_ER_PHAGOSOME_PATHWAY	0	2.74
Category members	Pathway	Pathway_807	REACTOME_SIGNALING_BY_WNT	0	2.74
Category members	GO Category	GO:0031145	anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process	Database	2.59
Category members	Pathway	Pathway_764	REACTOME_CLASS_I_MHC_MEDIATED_ANTIGEN_PROCESSING_PRESENTATION	0	2.56
Category members	GO Category	GO:0002474	antigen processing and presentation of peptide antigen via MHC class I	Database	2.5
Category members	Pathway	Pathway_780	REACTOME_APC_C_CDH1_MEDIATED_DEGRADATION_OF_CDC20_AND_OTHER_APC_C_CDH1_TARGETED_PROTEINS_IN_LATE_MITOSIS_EARLY_G1	0	2.46
Category members	GO Category	GO:0000209	protein polyubiquitination	Database	2.46
Category members	GO Category	GO:0002479	antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent	Database	2.46
Category members	GO Category	GO:0000724	double-strand break repair via homologous recombination	Database	2.41
Category members	Pathway	Pathway_837	REACTOME_APOPTOSIS	0	2.39
Category members	Pathway	Pathway_784	REACTOME_APC_C_CDC20_MEDIATED_DEGRADATION_OF_MITOTIC_PROTEINS	0	2.26
Category members	Pathway	Pathway_763	REACTOME_ANTIGEN_PROCESSING_CROSS_PRESENTATION	0	2.24
Category members	GO Category	GO:0042590	antigen processing and presentation of exogenous peptide antigen via MHC class I	Database	2.21
Category members	Pathway	Pathway_315	REACTOME_S_PHASE	0	2.19
Category members	Pathway	Pathway_660	REACTOME_SIGNALING_BY_THE_B_CELL_RECEPTOR_BCR	0	2.12
Category members	GO Category	GO:0006915	apoptotic process	Database	2.12
Category members	Pathway	Pathway_781	REACTOME_REGULATION_OF_MRNA_STABILITY_BY_PROTEINS_THAT_BIND_AU_RICH_ELEMENTS	0	2.04
Category members	Pathway	Pathway_330	REACTOME_SYNTHESIS_OF_DNA	0	1.96
Category members	Pathway	Pathway_706	REACTOME_DOWNSTREAM_SIGNALING_EVENTS_OF_B_CELL_RECEPTOR_BCR	0	1.96
Category members	Pathway	Pathway_788	REACTOME_REGULATION_OF_MITOTIC_CELL_CYCLE	0	1.91
Category members	Pathway	Pathway_322	REACTOME_G1_S_TRANSITION	0	1.77
Category members	Pathway	Pathway_820	REACTOME_ORC1_REMOVAL_FROM_CHROMATIN	0	1.75
Category members	Pathway	Pathway_798	REACTOME_P53_INDEPENDENT_G1_S_DNA_DAMAGE_CHECKPOINT	0	1.64
Category members	Pathway	Pathway_787	REACTOME_ASSEMBLY_OF_THE_PRE_REPLICATIVE_COMPLEX	0	1.59
Category members	Pathway	Pathway_832	REACTOME_ANTIGEN_PROCESSING_UBIQUITINATION_PROTEASOME_DEGRADATION	0	1.58
Category members	Pathway	Pathway_313	REACTOME_MITOTIC_G1_G1_S_PHASES	0	1.45
Category members	Pathway	Pathway_776	REACTOME_DESTABILIZATION_OF_MRNA_BY_AUF1_HNRNP_D0	0	1.45
Category members	Pathway	Pathway_331	REACTOME_M_G1_TRANSITION	0	1.43
Category members	GO Category	GO:0006977	DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest	Database	1.39
Category members	GO Category	GO:0004221	ubiquitin thiolesterase activity	Database	1.36
Category members	GO Category	GO:0022624	proteasome accessory complex	Database	1.36
Category members	Pathway	Pathway_900	KEGG_PROTEASOME	0	1.34
Category members	Pathway	Pathway_817	REACTOME_CDK_MEDIATED_PHOSPHORYLATION_AND_REMOVAL_OF_CDC6	0	1.24
Category members	GO Category	GO:0000082	G1/S transition of mitotic cell cycle	Database	1.23
Category members	Pathway	Pathway_796	REACTOME_VIF_MEDIATED_DEGRADATION_OF_APOBEC3G	0	1.14
Category members	Pathway	Pathway_811	REACTOME_SCF_BETA_TRCP_MEDIATED_DEGRADATION_OF_EMI1	0	1.14
Category members	Pathway	Pathway_801	REACTOME_AUTODEGRADATION_OF_THE_E3_UBIQUITIN_LIGASE_COP1	0	1.09
Category members	Pathway	Pathway_910	REACTOME_CROSS_PRESENTATION_OF_SOLUBLE_EXOGENOUS_ANTIGENS_ENDOSOMES	0	1.03
Category members	Pathway	Pathway_830	REACTOME_P53_DEPENDENT_G1_DNA_DAMAGE_RESPONSE	0	0.93
Category members	Pathway	Pathway_804	REACTOME_ACTIVATION_OF_NF_KAPPAB_IN_B_CELLS	0	0.86
Category members	Pathway	Pathway_467	BIOCARTA_PROTEASOME_PATHWAY	0	0.82
Category members	Pathway	Pathway_828	REACTOME_CDT1_ASSOCIATION_WITH_THE_CDC6_ORC_ORIGIN_COMPLEX	0	0.82
Category members	GO Category	GO:0006303	double-strand break repair via nonhomologous end joining	Database	0.79
Category members	GO Category	GO:0042981	regulation of apoptotic process	Database	0.79
Category members	Pathway	Pathway_782	REACTOME_SCFSKP2_MEDIATED_DEGRADATION_OF_P27_P21	0	0.66
Category members	Pathway	Pathway_835	REACTOME_CYCLIN_E_ASSOCIATED_EVENTS_DURING_G1_S_TRANSITION_	0	0.63
Category members	GO Category	GO:0006521	regulation of cellular amino acid metabolic process	Database	0.62
Category members	GO Category	GO:0043066	negative regulation of apoptotic process	Database	0.6
Category members	GO Category	GO:0070628	proteasome binding	Database	0.46
Category members	Pathway	Pathway_441	REACTOME_REGULATION_OF_ORNITHINE_DECARBOXYLASE_ODC	0	0.45
Category members	GO Category	GO:0044281	small molecule metabolic process	Database	0.35
Category members	Pathway	Pathway_795	REACTOME_REGULATION_OF_APOPTOSIS	0	0.31
Category members	GO Category	GO:0070536	protein K63-linked deubiquitination	Database	0.29
Category members	GO Category	GO:0010950	positive regulation of endopeptidase activity	Database	0.04
Category members	GO Category	GO:0034641	cellular nitrogen compound metabolic process	Database	0.01
Category members	Pathway	Pathway_17	REACTOME_METABOLISM_OF_AMINO_ACIDS_AND_DERIVATIVES	0	0
Category members	GO Category	GO:0008237	metallopeptidase activity	Database	0
Category members	GO Category	GO:0046872	metal ion binding	Database	0
Category members	GO Category	GO:0061133	endopeptidase activator activity	Database	0
Category members	GO Category	GO:0061136	regulation of proteasomal protein catabolic process	Database	0