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Query: PNKP

RNAi screen result RNAPII IP (PI) CSB IP CSB IP (PI) Chrom. Chrom. (PI) Phosphorylation Ubiquitylation
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[Click on the plots to view the data selection in the respective scatterplot]

Protein Results:

 Results for post-translational modifications: see below | Red/green: hit at lower/upper end of the respective screen
Gene name Point score Z-score sums RNAi high RNAi low RNAPII-IP (PI) CSB-IP CSB-IP (PI) Chrom. Chrom. (PI)
PNKP 0 -4.570 1.170 -0.260 -1.642 0.133 0.861

PTM Sites:

 Back to Protein Results | Red/green: hit at lower/upper end of the respective screen
Gene name PTM type PTM site UV UV (PI) Sequence
PNKP Phosphorylation T118 -2.016 -2.084 _TPESQPDT(ph)PPGTPLVSQDEK_
PNKP Ubiquitylation K226 0.178 _GK(gl)LPAEEFK_

Background Information for PNKP:


Pubmed-PNKP »
Uniprot-PNKP »
Biogrid-PNKP »
ProteomicsDB-PNKP »

Tumorportal-PNKP »
COSMIC-PNKP »
GenomeRNAi-PNKP »
Genecards-PNKP


Protein-protein Interactions for PNKP
Show screen data for Category Name and Description Link to cat description Data Source
Category members IP bait XRCC1 Cat. description Hein, Mann, Cell 2015
Category members IP bait CCDC43 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait PNKP Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait POLB Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait XRCC4 Cat. description BioPlex, Huttlin, Gygi, Cell 2015


Protein Domains in PNKP
Domain name Domain Description TC-NER relevance -log10(p-value)
Category members P-loop_NTPase IPR027417 2.83
Category members SMAD_FHA_domain IPR008984 0.86
Category members HAD-like_dom IPR023214 0


Protein complexes (CORUM database) featuring PNKP
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)
Category members Corum 350 DNA ligase IV-XRCC4-PNK complex Database 0
Category members Corum 362 DNA ligase III-XRCC1-PNK-DNA-pol III multiprotein complex Database 0
Category members Corum 5243 XRCC1-LIG3-PNK-TDP1 complex Database 0


Categories featuring PNKP
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)
Category members DDR Literature pubmedid:24332808 Marechal et al., 2014 RPA-mediated recruitment INF
Category members GO Category GO:0005515 protein binding Database INF
Category members GO Category GO:0005634 nucleus Database INF
Category members GO Category GO:0006281 DNA repair Database INF
Category members GO Category GO:0005730 nucleolus Database 13.38
Category members GO Category GO:0005524 ATP binding Database 5.54
Category members GO Category GO:0003684 damaged DNA binding Database 4.54
Category members GO Category GO:0000718 nucleotide-excision repair, DNA damage removal Database 3.83
Category members GO Category GO:0003690 double-stranded DNA binding Database 0.66
Category members GO Category GO:0006261 DNA-dependent DNA replication Database 0.48
Category members GO Category GO:0017076 purine nucleotide binding Database 0.23
Category members GO Category GO:0009314 response to radiation Database 0.07
Category members Pathway Pathway_967 PID_DNA_PK_PATHWAY 0 0.04
Category members GO Category GO:0046403 polynucleotide 3'-phosphatase activity Database 0.04
Category members GO Category GO:0004519 endonuclease activity Database 0
Category members GO Category GO:0006979 response to oxidative stress Database 0
Category members GO Category GO:0016311 dephosphorylation Database 0
Category members GO Category GO:0019201 nucleotide kinase activity Database 0
Category members GO Category GO:0042769 DNA damage response, detection of DNA damage Database 0
Category members GO Category GO:0046404 ATP-dependent polydeoxyribonucleotide 5'-hydroxyl-kinase activity Database 0
Category members GO Category GO:0046939 nucleotide phosphorylation Database 0


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