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Query: PMS2

This is a cancer-associated gene according to the Sanger cancer gene census.

RNAi screen result RNAPII IP (PI) CSB IP CSB IP (PI) Chrom. Chrom. (PI) Phosphorylation Ubiquitylation
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[Click on the plots to view the data selection in the respective scatterplot]

Protein Results:

 Results for post-translational modifications: see below | Red/green: hit at lower/upper end of the respective screen
Gene name Point score Z-score sums RNAi high RNAi low RNAPII-IP (PI) CSB-IP CSB-IP (PI) Chrom. Chrom. (PI)
PMS2 0 -0.403 0.410 -0.450

PTM Sites:

 Back to Protein Results | Red/green: hit at lower/upper end of the respective screen
Gene name PTM type PTM site UV UV (PI) Sequence
PMS2 Ubiquitylation K146 -0.403 _IIQK(gl)TPYPRPR_

Background Information for PMS2:


Pubmed-PMS2 »
Uniprot-PMS2 »
Biogrid-PMS2 »
ProteomicsDB-PMS2 »

Tumorportal-PMS2 »
COSMIC-PMS2 »
GenomeRNAi-PMS2 »
Genecards-PMS2


Protein-protein Interactions for PMS2
Show screen data for Category Name and Description Link to cat description Data Source
Category members IP bait CTR9 Cat. description Hein, Mann, Cell 2015
Category members IP bait FAN1 Cat. description Hein, Mann, Cell 2015
Category members IP bait MCM3 Cat. description Hein, Mann, Cell 2015
Category members IP bait PARD6A Cat. description Hein, Mann, Cell 2015
Category members IP bait PMS2 Cat. description Hein, Mann, Cell 2015
Category members IP bait PRKAA1 Cat. description Hein, Mann, Cell 2015
Category members IP bait XRCC3 Cat. description Hein, Mann, Cell 2015


Protein Domains in PMS2
Domain name Domain Description TC-NER relevance -log10(p-value)
Category members HATPase_C IPR003594 1.07
Category members Ribosomal_S5_D2-typ_fold IPR020568 1.06
Category members DNA_mismatch_repair_fam IPR002099 0
Category members DNA_mismatch_repair_C IPR013507 0


Protein complexes (CORUM database) featuring PMS2
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)
Category members Corum 376 PCNA-MutS-alpha-MutL-alpha-DNA complex Database 0.43
Category members Corum 290 MSH2-MLH1-PMS2-PCNA DNA-repair initiation complex Database 0.18
Category members Corum 369 MSH2-MSH6-PMS2-MLH1 complex Database 0.18
Category members Corum 431 MSH2-MSH6-PMS2-MLH1 complex Database 0.18
Category members Corum 291 MSH2-MLH1-PMS2 DNA-repair initiation complex Database 0
Category members Corum 292 MutL-alpha complex Database 0
Category members Corum 379 MutL-alpha complex Database 0
Category members Corum 415 EXO1-MLH1-PMS2 complex Database 0
Category members Corum 423 EXO1-MLH1-PMS2 complex Database 0


Categories featuring PMS2
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)
Category members GO Category GO:0005515 protein binding Database INF
Category members GO Category GO:0005634 nucleus Database INF
Category members GO Category GO:0006281 DNA repair Database INF
Category members GO Category GO:0005524 ATP binding Database 5.54
Category members Human mutations Sanger_cancer_genes Sanger cancer genes Database 4.88
Category members GO Category GO:0003697 single-stranded DNA binding Database 4.24
Category members GO Category GO:0006974 cellular response to DNA damage stimulus Database 3.57
Category members GO Category GO:0016887 ATPase activity Database 2.28
Category members GO Category GO:0006200 ATP catabolic process Database 2.13
Category members GO Category GO:0003677 DNA binding Database 1.53
Category members Pathway Pathway_341 KEGG_MISMATCH_REPAIR 0 1.02
Category members GO Category GO:0042493 response to drug Database 0.66
Category members GO Category GO:0006298 mismatch repair Database 0.33
Category members GO Category GO:0030983 mismatched DNA binding Database 0.27
Category members Pathway Pathway_383 PID_P53_DOWNSTREAM_PATHWAY 0 0.23
Category members GO Category GO:0016447 somatic recombination of immunoglobulin gene segments Database 0.21
Category members Disease phenotype Constitutional_mismatch_repair_deficiency_syndrome Constitutional mismatch repair deficiency syndrome Database 0.18
Category members Disease phenotype MISMATCH_REPAIR_CANCER_SYNDROME MISMATCH REPAIR CANCER SYNDROME Database 0.18
Category members Disease phenotype Nonpolyposis_Turcot_syndrome Nonpolyposis Turcot syndrome Database 0.18
Category members Disease phenotype Hereditary_nonpolyposis_colon_cancer Hereditary nonpolyposis colon cancer Database 0.14
Category members GO Category GO:0004519 endonuclease activity Database 0
Category members GO Category GO:0007131 reciprocal meiotic recombination Database 0
Category members GO Category GO:0016446 somatic hypermutation of immunoglobulin genes Database 0
Category members GO Category GO:0032300 mismatch repair complex Database 0
Category members GO Category GO:0032389 MutLalpha complex Database 0
Category members GO Category GO:0032407 MutSalpha complex binding Database 0


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