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Query: PLXNA3

RNAi screen result RNAPII IP (PI) CSB IP CSB IP (PI) Chrom. Chrom. (PI) Phosphorylation Ubiquitylation
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[Click on the plots to view the data selection in the respective scatterplot]

Protein Results:

 Results for post-translational modifications: see below | Red/green: hit at lower/upper end of the respective screen
Gene name Point score Z-score sums RNAi high RNAi low RNAPII-IP (PI) CSB-IP CSB-IP (PI) Chrom. Chrom. (PI)
PLXNA3 1 1.613 -0.130 0.400

PTM Sites:

 Back to Protein Results | Red/green: hit at lower/upper end of the respective screen
Gene name PTM type PTM site UV UV (PI) Sequence
PLXNA3 Ubiquitylation K622 2.255 _LQLLSK(gl)ETGVR_
PLXNA3 Ubiquitylation K1328 -1.042 -1.740 _ELDTPPNVEK(gl)ALR_

Background Information for PLXNA3:


Pubmed-PLXNA3 »
Uniprot-PLXNA3 »
Biogrid-PLXNA3 »
ProteomicsDB-PLXNA3 »

Tumorportal-PLXNA3 »
COSMIC-PLXNA3 »
GenomeRNAi-PLXNA3 »
Genecards-PLXNA3


Protein-protein Interactions for PLXNA3
Show screen data for Category Name and Description Link to cat description Data Source
Category members IP bait ACTR5 Cat. description Hein, Mann, Cell 2015
Category members IP bait BAG3 Cat. description Hein, Mann, Cell 2015
Category members IP bait BAG6;BAT3 Cat. description Hein, Mann, Cell 2015
Category members IP bait CCDC22 Cat. description Hein, Mann, Cell 2015
Category members IP bait CNTROB Cat. description Hein, Mann, Cell 2015
Category members IP bait CYR61 Cat. description Hein, Mann, Cell 2015
Category members IP bait ECT2 Cat. description Hein, Mann, Cell 2015
Category members IP bait EXOSC2 Cat. description Hein, Mann, Cell 2015
Category members IP bait FIGN Cat. description Hein, Mann, Cell 2015
Category members IP bait GAK Cat. description Hein, Mann, Cell 2015
Category members IP bait GSPT1;GSPT2 Cat. description Hein, Mann, Cell 2015
Category members IP bait HSF2 Cat. description Hein, Mann, Cell 2015
Category members IP bait IQGAP3 Cat. description Hein, Mann, Cell 2015
Category members IP bait KCTD5 Cat. description Hein, Mann, Cell 2015
Category members IP bait KIF1C Cat. description Hein, Mann, Cell 2015
Category members IP bait KIF21A Cat. description Hein, Mann, Cell 2015
Category members IP bait KIF4A Cat. description Hein, Mann, Cell 2015
Category members IP bait KLC4 Cat. description Hein, Mann, Cell 2015
Category members IP bait MAD2L1BP Cat. description Hein, Mann, Cell 2015
Category members IP bait MED22 Cat. description Hein, Mann, Cell 2015
Category members IP bait MKNK2 Cat. description Hein, Mann, Cell 2015
Category members IP bait MLH1 Cat. description Hein, Mann, Cell 2015
Category members IP bait NDC80 Cat. description Hein, Mann, Cell 2015
Category members IP bait NEDD1 Cat. description Hein, Mann, Cell 2015
Category members IP bait OAZ1 Cat. description Hein, Mann, Cell 2015
Category members IP bait PARD6A Cat. description Hein, Mann, Cell 2015
Category members IP bait PCDHB15 Cat. description Hein, Mann, Cell 2015
Category members IP bait POLK Cat. description Hein, Mann, Cell 2015
Category members IP bait SGTB Cat. description Hein, Mann, Cell 2015
Category members IP bait SMC6 Cat. description Hein, Mann, Cell 2015
Category members IP bait SPATS2L Cat. description Hein, Mann, Cell 2015
Category members IP bait SYNCRIP Cat. description Hein, Mann, Cell 2015
Category members IP bait TPX2 Cat. description Hein, Mann, Cell 2015
Category members IP bait TRAPPC11 Cat. description Hein, Mann, Cell 2015
Category members IP bait TUBA3C;TUBA3E Cat. description Hein, Mann, Cell 2015
Category members IP bait USF1;usf1 Cat. description Hein, Mann, Cell 2015
Category members IP bait HLA-E Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait SCGB1D1 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait SCGB2A2 Cat. description BioPlex, Huttlin, Gygi, Cell 2015


Protein Domains in PLXNA3
Domain name Domain Description TC-NER relevance -log10(p-value)
Category members Rho_GTPase_activation_prot IPR008936 0.53
Category members Plexin_cytoplasmic_RasGAP_dom IPR013548 0.31
Category members IPT IPR002909 0.11
Category members Semap_dom IPR001627 0.04
Category members Plexin_repeat IPR002165 0
Category members Ig_E-set IPR014756 0
Category members Plexin-like_fold IPR016201 0


Protein complexes (CORUM database) featuring PLXNA3
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)
Category members Corum 5648 FARP2-NRP1-PlexinA3 complex Database 0.35
Category members Corum 5759 PLXNA3-RANBPM complex Database 0.13


Categories featuring PLXNA3
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)
Category members GO Category GO:0005515 protein binding Database INF
Category members GO Category GO:0016021 integral to membrane Database 7.67
Category members DDR Literature pubmedid:19647519 Paulsen et al., 2009 siRNA screen for g-H2A.x phosphorylation 3.6
Category members Pathway Pathway_1147 REACTOME_SEMA3A_PAK_DEPENDENT_AXON_REPULSION 0 1.89
Category members GO Category GO:0005886 plasma membrane Database 1.21
Category members Pathway Pathway_673 REACTOME_AXON_GUIDANCE 0 1.06
Category members Pathway Pathway_674 REACTOME_SEMAPHORIN_INTERACTIONS 0 0.96
Category members Pathway Pathway_672 REACTOME_SEMA3A_PLEXIN_REPULSION_SIGNALING_BY_INHIBITING_INTEGRIN_ADHESION 0 0.88
Category members GO Category GO:0016020 membrane Database 0.52
Category members Pathway Pathway_42 REACTOME_DEVELOPMENTAL_BIOLOGY 0 0.32
Category members GO Category GO:0005622 intracellular Database 0.32
Category members GO Category GO:0007275 multicellular organismal development Database 0.31
Category members GO Category GO:0017154 semaphorin receptor activity Database 0.31
Category members Pathway Pathway_1282 REACTOME_CRMPS_IN_SEMA3A_SIGNALING 0 0.17
Category members GO Category GO:0004888 transmembrane signaling receptor activity Database 0.15
Category members GO Category GO:0007411 axon guidance Database 0.13
Category members GO Category GO:0021860 pyramidal neuron development Database 0.11
Category members GO Category GO:0002116 semaphorin receptor complex Database 0.05
Category members Pathway Pathway_1034 KEGG_AXON_GUIDANCE 0 0.04
Category members GO Category GO:0004872 receptor activity Database 0
Category members GO Category GO:0007165 signal transduction Database 0
Category members GO Category GO:0021766 hippocampus development Database 0
Category members GO Category GO:0048843 negative regulation of axon extension involved in axon guidance Database 0
Category members GO Category GO:0050919 negative chemotaxis Database 0
Category members GO Category GO:0051495 positive regulation of cytoskeleton organization Database 0


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