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Query: PKP2

RNAi screen result RNAPII IP (PI) CSB IP CSB IP (PI) Chrom. Chrom. (PI) Phosphorylation Ubiquitylation
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[Click on the plots to view the data selection in the respective scatterplot]

Protein Results:

 Results for post-translational modifications: see below | Red/green: hit at lower/upper end of the respective screen
Gene name Point score Z-score sums RNAi high RNAi low RNAPII-IP (PI) CSB-IP CSB-IP (PI) Chrom. Chrom. (PI)
PKP2 0 5.807 0.120 0.970
PKP2 0 5.807 0.120 0.970 0.814 0.742

PTM Sites:

 Back to Protein Results | Red/green: hit at lower/upper end of the respective screen
Gene name PTM type PTM site UV UV (PI) Sequence
PKP2 Ubiquitylation K643 1.209 0.678 _NIQTDNNK(gl)SIGCFGSR_
PKP2 Phosphorylation S135 0.873 0.521 _GTAQYSSQKS(ph)VEER_
PKP2 Phosphorylation S82 0.172 0.473 _TSS(ph)VPEYVYNLHLVENDFVGGR_
PKP2 Phosphorylation S151 0.440 0.323 _RLEIS(ph)PDSSPER_
PKP2 Phosphorylation S329 0.351 0.264 _AHLTVGQAAAGGS(ph)GNLLTER_
PKP2 Phosphorylation S154 0.267 0.205 _LEISPDS(ph)SPER_
PKP2 Phosphorylation S155 -0.249 0.172 _RLEISPDSS(ph)PER_
PKP2 Ubiquitylation K134 0.755 -0.110 _GTAQYSSQK(gl)SVEER_

Background Information for PKP2:


Pubmed-PKP2 »
Uniprot-PKP2 »
Biogrid-PKP2 »
ProteomicsDB-PKP2 »

Tumorportal-PKP2 »
COSMIC-PKP2 »
GenomeRNAi-PKP2 »
Genecards-PKP2


Protein-protein Interactions for PKP2
Show screen data for Category Name and Description Link to cat description Data Source
Category members IP bait APC Cat. description Hein, Mann, Cell 2015
Category members IP bait GTSE1 Cat. description Hein, Mann, Cell 2015
Category members IP bait MATR3 Cat. description Hein, Mann, Cell 2015
Category members IP bait SEC16A Cat. description Hein, Mann, Cell 2015
Category members IP bait SEC24C Cat. description Hein, Mann, Cell 2015
Category members IP bait USO1 Cat. description Hein, Mann, Cell 2015
Category members IP bait C12orf59 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait EFNB2 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait FAM188A Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait GRN Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait HAVCR2 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait KBTBD5 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait LPAR6 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait LRRC4C Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait PCDHGB1 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait PTGER3 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait SLC14A2 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait TACR1 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait TNFRSF19 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait WDYHV1 Cat. description BioPlex, Huttlin, Gygi, Cell 2015


Protein Domains in PKP2
Domain name Domain Description TC-NER relevance -log10(p-value)
Category members ARM-type_fold IPR016024 9.26
Category members Armadillo IPR000225 1.58


Protein complexes (CORUM database) featuring PKP2
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)


Categories featuring PKP2
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)
Category members GO Category GO:0005515 protein binding Database INF
Category members GO Category GO:0005634 nucleus Database INF
Category members GO Category GO:0005488 binding Database 9.32
Category members GO Category GO:0016021 integral to membrane Database 7.67
Category members DDR Literature pubmedid:19647519 Paulsen et al., 2009 siRNA screen for g-H2A.x phosphorylation 3.6
Category members GO Category GO:0005911 cell-cell junction Database 1.4
Category members GO Category GO:0005886 plasma membrane Database 1.21
Category members GO Category GO:0030336 negative regulation of cell migration Database 0.85
Category members GO Category GO:0032947 protein complex scaffold Database 0.82
Category members GO Category GO:0014704 intercalated disc Database 0.64
Category members GO Category GO:0017080 sodium channel regulator activity Database 0.37
Category members GO Category GO:0016264 gap junction assembly Database 0.35
Category members GO Category GO:0008285 negative regulation of cell proliferation Database 0.28
Category members GO Category GO:0030057 desmosome Database 0.26
Category members GO Category GO:0005912 adherens junction Database 0.25
Category members GO Category GO:0002159 desmosome assembly Database 0.21
Category members GO Category GO:0048496 maintenance of organ identity Database 0.17
Category members GO Category GO:0019215 intermediate filament binding Database 0.13
Category members GO Category GO:0003674 molecular_function Database 0.08
Category members Disease phenotype Familial_isolated_arrhythmogenic_ventricular_dysplasia_biventricular_form Familial isolated arrhythmogenic ventricular dysplasia biventricular form Database 0.05
Category members Disease phenotype Familial_isolated_arrhythmogenic_ventricular_dysplasia_left_dominant_form Familial isolated arrhythmogenic ventricular dysplasia left dominant form Database 0.05
Category members Disease phenotype Familial_isolated_arrhythmogenic_ventricular_dysplasia_right_dominant_form Familial isolated arrhythmogenic ventricular dysplasia right dominant form Database 0.05
Category members GO Category GO:0005080 protein kinase C binding Database 0.04
Category members GO Category GO:0044325 ion channel binding Database 0.03
Category members Pathway Pathway_1007 KEGG_ARRHYTHMOGENIC_RIGHT_VENTRICULAR_CARDIOMYOPATHY_ARVC 0 0.03
Category members GO Category GO:0005882 intermediate filament Database 0
Category members GO Category GO:0007507 heart development Database 0
Category members GO Category GO:0010765 positive regulation of sodium ion transport Database 0
Category members GO Category GO:0016337 cell-cell adhesion Database 0
Category members GO Category GO:0045110 intermediate filament bundle assembly Database 0
Category members GO Category GO:0055010 ventricular cardiac muscle tissue morphogenesis Database 0
Category members GO Category GO:0055088 lipid homeostasis Database 0


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