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Query: PIKFYVE

RNAi screen result RNAPII IP (PI) CSB IP CSB IP (PI) Chrom. Chrom. (PI) Phosphorylation Ubiquitylation
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[Click on the plots to view the data selection in the respective scatterplot]

Protein Results:

 Results for post-translational modifications: see below | Red/green: hit at lower/upper end of the respective screen
Gene name Point score Z-score sums RNAi high RNAi low RNAPII-IP (PI) CSB-IP CSB-IP (PI) Chrom. Chrom. (PI)
PIKFYVE 0 1.302 -0.230 0.410

PTM Sites:

 Back to Protein Results | Red/green: hit at lower/upper end of the respective screen
Gene name PTM type PTM site UV UV (PI) Sequence
PIKFYVE Phosphorylation S307 0.463 0.429 _SAS(ph)ITNLSLDR_
PIKFYVE Phosphorylation S1754 -0.097 0.057 _GTAGKS(ph)PDLSSQK_
PIKFYVE Phosphorylation S1714 -0.557 _SSS(ph)PIRLPEMSGGQTNR_

Background Information for PIKFYVE:


Pubmed-PIKFYVE »
Uniprot-PIKFYVE »
Biogrid-PIKFYVE »
ProteomicsDB-PIKFYVE »

Tumorportal-PIKFYVE »
COSMIC-PIKFYVE »
GenomeRNAi-PIKFYVE »
Genecards-PIKFYVE


Protein-protein Interactions for PIKFYVE
Show screen data for Category Name and Description Link to cat description Data Source
Category members IP bait ANK1 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait FIG4 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait TIMM23 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait VAC14 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait WDR83 Cat. description BioPlex, Huttlin, Gygi, Cell 2015


Protein Domains in PIKFYVE
Domain name Domain Description TC-NER relevance -log10(p-value)
Category members Znf_FYVE_PHD IPR011011 1.23
Category members Cpn60/TCP-1 IPR002423 0.09
Category members GroEL-like_apical_dom IPR027409 0.09
Category members DEP_dom IPR000591 0.07
Category members Znf_FYVE IPR000306 0
Category members PInositol-4-P-5-kinase_core IPR002498 0
Category members PInositol-4P-5-kinase_core_sub IPR016034 0
Category members Znf_FYVE-rel IPR017455 0


Protein complexes (CORUM database) featuring PIKFYVE
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)


Categories featuring PIKFYVE
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)
Category members GO Category GO:0005515 protein binding Database INF
Category members GO Category GO:0005829 cytosol Database INF
Category members GO Category GO:0044267 cellular protein metabolic process Database 10.42
Category members GO Category GO:0005524 ATP binding Database 5.54
Category members Pathway Pathway_666 KEGG_ENDOCYTOSIS 0 1.25
Category members GO Category GO:0031901 early endosome membrane Database 0.58
Category members Pathway Pathway_501 REACTOME_SYNTHESIS_OF_PIPS_AT_THE_GOLGI_MEMBRANE 0 0.46
Category members GO Category GO:0048471 perinuclear region of cytoplasm Database 0.39
Category members GO Category GO:0044281 small molecule metabolic process Database 0.35
Category members Pathway Pathway_106 KEGG_INOSITOL_PHOSPHATE_METABOLISM 0 0.28
Category members GO Category GO:0042147 retrograde transport, endosome to Golgi Database 0.26
Category members GO Category GO:0034504 protein localization to nucleus Database 0.15
Category members GO Category GO:0045121 membrane raft Database 0.11
Category members Pathway Pathway_499 KEGG_FC_GAMMA_R_MEDIATED_PHAGOCYTOSIS 0 0.1
Category members Pathway Pathway_580 KEGG_REGULATION_OF_ACTIN_CYTOSKELETON 0 0.08
Category members GO Category GO:0043813 phosphatidylinositol-3,5-bisphosphate 5-phosphatase activity Database 0.08
Category members GO Category GO:0006661 phosphatidylinositol biosynthetic process Database 0.06
Category members Pathway Pathway_103 REACTOME_PI_METABOLISM 0 0.04
Category members GO Category GO:0032288 myelin assembly Database 0.02
Category members Pathway Pathway_100 REACTOME_PHOSPHOLIPID_METABOLISM 0 0
Category members Pathway Pathway_104 REACTOME_SYNTHESIS_OF_PIPS_AT_THE_LATE_ENDOSOME_MEMBRANE 0 0
Category members Pathway Pathway_105 REACTOME_SYNTHESIS_OF_PIPS_AT_THE_EARLY_ENDOSOME_MEMBRANE 0 0
Category members Pathway Pathway_4 REACTOME_METABOLISM_OF_LIPIDS_AND_LIPOPROTEINS 0 0
Category members Pathway Pathway_488 KEGG_PHOSPHATIDYLINOSITOL_SIGNALING_SYSTEM 0 0
Category members GO Category GO:0000139 Golgi membrane Database 0
Category members GO Category GO:0006644 phospholipid metabolic process Database 0
Category members GO Category GO:0010008 endosome membrane Database 0
Category members GO Category GO:0016307 phosphatidylinositol phosphate kinase activity Database 0
Category members GO Category GO:0016308 1-phosphatidylinositol-4-phosphate 5-kinase activity Database 0
Category members GO Category GO:0031410 cytoplasmic vesicle Database 0
Category members GO Category GO:0031902 late endosome membrane Database 0
Category members GO Category GO:0035556 intracellular signal transduction Database 0
Category members GO Category GO:0036092 phosphatidylinositol-3-phosphate biosynthetic process Database 0
Category members GO Category GO:0046488 phosphatidylinositol metabolic process Database 0
Category members GO Category GO:0046872 metal ion binding Database 0


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