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Query: PHGDH

RNAi screen result RNAPII IP (PI) CSB IP CSB IP (PI) Chrom. Chrom. (PI) Phosphorylation Ubiquitylation
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[Click on the plots to view the data selection in the respective scatterplot]

Protein Results:

 Results for post-translational modifications: see below | Red/green: hit at lower/upper end of the respective screen
Gene name Point score Z-score sums RNAi high RNAi low RNAPII-IP (PI) CSB-IP CSB-IP (PI) Chrom. Chrom. (PI)
PHGDH 0 3.129 -0.190 -0.280 0.032 -0.024 -0.302 1.449 0.834

PTM Sites:

 Back to Protein Results | Red/green: hit at lower/upper end of the respective screen
Gene name PTM type PTM site UV UV (PI) Sequence
PHGDH Ubiquitylation K69 0.277 0.839 _VTADVINAAEK(gl)LQVVGR_
PHGDH Ubiquitylation K21 0.211 0.538 _K(gl)ILQDGGLQVVEK_
PHGDH Ubiquitylation K58 -0.078 0.489 _SATK(gl)VTADVINAAEK_
PHGDH Ubiquitylation K351 -0.346 0.413 _AWAGSPK(gl)GTIQVITQGTSLK_
PHGDH Ubiquitylation K384 -0.129 -0.044 _EASK(gl)QADVNLVNAK_
PHGDH Ubiquitylation K289 -0.629 -0.819 _ALVDHENVISCPHLGASTK(gl)EAQSR_
PHGDH Ubiquitylation K394 -0.043 _QADVNLVNAK(gl)LLVK_

Background Information for PHGDH:


Pubmed-PHGDH »
Uniprot-PHGDH »
Biogrid-PHGDH »
ProteomicsDB-PHGDH »

Tumorportal-PHGDH »
COSMIC-PHGDH »
GenomeRNAi-PHGDH »
Genecards-PHGDH


Protein-protein Interactions for PHGDH
Show screen data for Category Name and Description Link to cat description Data Source
Category members IP bait BMPR1A Cat. description Hein, Mann, Cell 2015
Category members IP bait CALML3 Cat. description Hein, Mann, Cell 2015
Category members IP bait GAK Cat. description Hein, Mann, Cell 2015
Category members IP bait GTSE1 Cat. description Hein, Mann, Cell 2015
Category members IP bait KIF20A Cat. description Hein, Mann, Cell 2015
Category members IP bait SLC33A1 Cat. description Hein, Mann, Cell 2015
Category members IP bait TUBA1C Cat. description Hein, Mann, Cell 2015
Category members IP bait EPN3 Cat. description BioPlex, Huttlin, Gygi, Cell 2015


Protein Domains in PHGDH
Domain name Domain Description TC-NER relevance -log10(p-value)
Category members D-isomer_DH_NAD-bd IPR006140 0.03
Category members D-isomer_2_OHA_DH_cat_dom IPR006139 0


Protein complexes (CORUM database) featuring PHGDH
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)


Categories featuring PHGDH
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)
Category members GO Category GO:0005829 cytosol Database INF
Category members GO Category GO:0051287 NAD binding Database 1.6
Category members GO Category GO:0006541 glutamine metabolic process Database 0.47
Category members GO Category GO:0006544 glycine metabolic process Database 0.35
Category members GO Category GO:0044281 small molecule metabolic process Database 0.35
Category members GO Category GO:0009448 gamma-aminobutyric acid metabolic process Database 0.32
Category members GO Category GO:0016616 oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor Database 0.29
Category members GO Category GO:0006564 L-serine biosynthetic process Database 0.29
Category members GO Category GO:0022008 neurogenesis Database 0.16
Category members GO Category GO:0031175 neuron projection development Database 0.12
Category members GO Category GO:0048037 cofactor binding Database 0.08
Category members GO Category GO:0021915 neural tube development Database 0.03
Category members GO Category GO:0009055 electron carrier activity Database 0.02
Category members GO Category GO:0034641 cellular nitrogen compound metabolic process Database 0.01
Category members GO Category GO:0019530 taurine metabolic process Database 0.01
Category members Pathway Pathway_17 REACTOME_METABOLISM_OF_AMINO_ACIDS_AND_DERIVATIVES 0 0
Category members Pathway Pathway_20 KEGG_GLYCINE_SERINE_AND_THREONINE_METABOLISM 0 0
Category members Pathway Pathway_394 REACTOME_AMINO_ACID_SYNTHESIS_AND_INTERCONVERSION_TRANSAMINATION 0 0
Category members GO Category GO:0006563 L-serine metabolic process Database 0
Category members GO Category GO:0007420 brain development Database 0
Category members GO Category GO:0008152 metabolic process Database 0
Category members GO Category GO:0008652 cellular amino acid biosynthetic process Database 0
Category members GO Category GO:0010468 regulation of gene expression Database 0
Category members GO Category GO:0021510 spinal cord development Database 0
Category members GO Category GO:0021782 glial cell development Database 0
Category members GO Category GO:0022402 cell cycle process Database 0
Category members GO Category GO:0055114 oxidation-reduction process Database 0
Category members GO Category GO:0070314 G1 to G0 transition Database 0


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