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Query: PCSK6

RNAi screen result RNAPII IP (PI) CSB IP CSB IP (PI) Chrom. Chrom. (PI) Phosphorylation Ubiquitylation
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[Click on the plots to view the data selection in the respective scatterplot]

Protein Results:

 Results for post-translational modifications: see below | Red/green: hit at lower/upper end of the respective screen
Gene name Point score Z-score sums RNAi high RNAi low RNAPII-IP (PI) CSB-IP CSB-IP (PI) Chrom. Chrom. (PI)
PCSK6 0 -0.143 0.020 -0.380

PTM Sites:

 Back to Protein Results | Red/green: hit at lower/upper end of the respective screen
Gene name PTM type PTM site UV UV (PI) Sequence
PCSK6 Ubiquitylation K573 -0.143 _SQLLAK(gl)R_

Background Information for PCSK6:


Pubmed-PCSK6 »
Uniprot-PCSK6 »
Biogrid-PCSK6 »
ProteomicsDB-PCSK6 »

Tumorportal-PCSK6 »
COSMIC-PCSK6 »
GenomeRNAi-PCSK6 »
Genecards-PCSK6


Protein-protein Interactions for PCSK6
Show screen data for Category Name and Description Link to cat description Data Source
Category members IP bait TMEM25 Cat. description BioPlex, Huttlin, Gygi, Cell 2015


Protein Domains in PCSK6
Domain name Domain Description TC-NER relevance -log10(p-value)
Category members EG-like_dom IPR000742 1.74
Category members Peptidase_S8/S53_dom IPR000209 0
Category members PrprotnconvertsP IPR002884 0
Category members Furin_repeat IPR006212 0
Category members Galactose-bd-like IPR008979 0
Category members Prot_inh_propept IPR009020 0
Category members Growth_fac_rcpt_N_dom IPR009030 0
Category members PLAC IPR010909 0
Category members Peptidase_S8_subtilisin-rel IPR015500 0


Protein complexes (CORUM database) featuring PCSK6
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)


Categories featuring PCSK6
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)
Category members GO Category GO:0005515 protein binding Database INF
Category members GO Category GO:0005615 extracellular space Database 4.72
Category members Pathway Pathway_221 REACTOME_SIGNALLING_BY_NGF 0 2.14
Category members GO Category GO:0005796 Golgi lumen Database 0.64
Category members GO Category GO:0048011 neurotrophin TRK receptor signaling pathway Database 0.63
Category members GO Category GO:0005783 endoplasmic reticulum Database 0.62
Category members GO Category GO:0016485 protein processing Database 0.57
Category members GO Category GO:0016020 membrane Database 0.52
Category members GO Category GO:0031012 extracellular matrix Database 0.45
Category members Pathway Pathway_42 REACTOME_DEVELOPMENTAL_BIOLOGY 0 0.32
Category members GO Category GO:0008201 heparin binding Database 0.27
Category members GO Category GO:0032455 nerve growth factor processing Database 0.23
Category members GO Category GO:0032902 nerve growth factor production Database 0.22
Category members GO Category GO:0032940 secretion by cell Database 0.21
Category members GO Category GO:0009986 cell surface Database 0.17
Category members GO Category GO:0030510 regulation of BMP signaling pathway Database 0.09
Category members GO Category GO:0048406 nerve growth factor binding Database 0.08
Category members GO Category GO:0004252 serine-type endopeptidase activity Database 0.05
Category members GO Category GO:0008233 peptidase activity Database 0.02
Category members Pathway Pathway_1210 REACTOME_SIGNALING_BY_NODAL 0 0
Category members GO Category GO:0004175 endopeptidase activity Database 0
Category members GO Category GO:0006508 proteolysis Database 0
Category members GO Category GO:0007354 zygotic determination of anterior/posterior axis, embryo Database 0
Category members GO Category GO:0007368 determination of left/right symmetry Database 0
Category members GO Category GO:0009100 glycoprotein metabolic process Database 0
Category members GO Category GO:0012505 endomembrane system Database 0
Category members GO Category GO:0016486 peptide hormone processing Database 0


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