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Query: PARD3

RNAi screen result RNAPII IP (PI) CSB IP CSB IP (PI) Chrom. Chrom. (PI) Phosphorylation Ubiquitylation
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[Click on the plots to view the data selection in the respective scatterplot]

Protein Results:

 Results for post-translational modifications: see below | Red/green: hit at lower/upper end of the respective screen
Gene name Point score Z-score sums RNAi high RNAi low RNAPII-IP (PI) CSB-IP CSB-IP (PI) Chrom. Chrom. (PI)
PARD3 3 8.734 -1.810 4.070
PARD3 3 8.734 -1.810 4.070 0.184 0.180
PARD3 3 8.734 -1.810 4.070 0.910

PTM Sites:

 Back to Protein Results | Red/green: hit at lower/upper end of the respective screen
Gene name PTM type PTM site UV UV (PI) Sequence
PARD3 Phosphorylation T579 2.050 2.128 _AEDEDIVLT(ph)PDGTR_
PARD3 Phosphorylation S809 2.141 1.530 _AAISDSADCSLS(ph)PDVDPVLAFQR_
PARD3 Phosphorylation S850 1.009 1.041 _S(ph)KSMDLGIADETK_
PARD3 Phosphorylation S852 0.640 0.638 _S(ph)MDLGIADETK_
PARD3 Phosphorylation S383 0.377 0.343 _FS(ph)PDSQYIDNR_
PARD3 Phosphorylation S728 -0.196 0.339 _ISHSLYSGIEGLDES(ph)PSR_
PARD3 Phosphorylation S143 -0.152 0.186 _RS(ph)SDPALIGLSTSVSDSNFSSEEPSR_
PARD3 Phosphorylation S144 0.099 -0.057 _RS(ph)SDPALIGLSTSVSDSNFSSEEPSR_
PARD3 Phosphorylation S715 1.428 -0.219 _RIS(ph)HSLYSGIEGLDESPSR_
PARD3 Phosphorylation S795 0.353 -0.344 _S(ph)M(ox)DLVADETK_
PARD3 Phosphorylation S973 -0.243 -0.400 _ESVSTASDQPSHS(ph)LER_
PARD3 Phosphorylation S1178 -0.282 -0.511 _TYS(ph)FEQPWPNAR_
PARD3 Phosphorylation S692 -0.647 -0.931 _S(ph)PGSPPGPELPIETALDDRER_
PARD3 Phosphorylation S695 -0.895 -1.092 _SPGS(ph)PPGPELPIETALDDRER_
PARD3 Ubiquitylation K886 -0.879 _DVGPSLGLKK(gl)_

Background Information for PARD3:


Pubmed-PARD3 »
Uniprot-PARD3 »
Biogrid-PARD3 »
ProteomicsDB-PARD3 »

Tumorportal-PARD3 »
COSMIC-PARD3 »
GenomeRNAi-PARD3 »
Genecards-PARD3


Protein-protein Interactions for PARD3
Show screen data for Category Name and Description Link to cat description Data Source
Category members IP bait CDC23 Cat. description Hein, Mann, Cell 2015
Category members IP bait CDC26 Cat. description Hein, Mann, Cell 2015
Category members IP bait MMGT1 Cat. description Hein, Mann, Cell 2015
Category members IP bait PARD6A Cat. description Hein, Mann, Cell 2015
Category members IP bait PARD6B Cat. description Hein, Mann, Cell 2015
Category members IP bait PPP1CB Cat. description Hein, Mann, Cell 2015
Category members IP bait PRKCI Cat. description Hein, Mann, Cell 2015
Category members IP bait RASSF8 Cat. description Hein, Mann, Cell 2015
Category members IP bait VAPA Cat. description Hein, Mann, Cell 2015
Category members IP bait YAP1 Cat. description Hein, Mann, Cell 2015
Category members IP bait YWHAH Cat. description Hein, Mann, Cell 2015
Category members IP bait PARD6B Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait PSMC3 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait RASSF7 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait RASSF8 Cat. description BioPlex, Huttlin, Gygi, Cell 2015


Protein Domains in PARD3
Domain name Domain Description TC-NER relevance -log10(p-value)
Category members DUF3534 IPR021922 0.28
Category members PDZ IPR001478 0.15


Protein complexes (CORUM database) featuring PARD3
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)
Category members Corum 956 PAR-3-PAR-6B-PRKCI complex Database 0.52
Category members Corum 847 RICH1-PAR3-aPKC polarity complex Database 0.08
Category members Corum 826 PAR-3-VE-cadherin-beta-catenin complex Database 0.06
Category members Corum 5534 PLCB1-PARD3-PARD6A complex Database 0
Category members Corum 5535 PLCB3-PARD3-PARD6A complex Database 0
Category members Corum 831 PAR-6-PAR-3-VE-cadherin complex, endothelial Database 0
Category members Corum 918 PAR3-PAR6-PALS1 complex Database 0


Categories featuring PARD3
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)
Category members GO Category GO:0005515 protein binding Database INF
Category members GO Category GO:0005829 cytosol Database INF
Category members GO Category GO:0005737 cytoplasm Database 12.81
Category members GO Category GO:0043234 protein complex Database 2.73
Category members GO Category GO:0005938 cell cortex Database 2.26
Category members Pathway Pathway_413 KEGG_TIGHT_JUNCTION 0 2.08
Category members Pathway Pathway_1184 KEGG_NEUROACTIVE_LIGAND_RECEPTOR_INTERACTION 0 1.89
Category members GO Category GO:0005911 cell-cell junction Database 1.4
Category members Pathway Pathway_666 KEGG_ENDOCYTOSIS 0 1.25
Category members GO Category GO:0005886 plasma membrane Database 1.21
Category members GO Category GO:0007163 establishment or maintenance of cell polarity Database 1.08
Category members GO Category GO:0005913 cell-cell adherens junction Database 1.05
Category members Pathway Pathway_777 REACTOME_SIGNALING_BY_TGF_BETA_RECEPTOR_COMPLEX 0 0.89
Category members Pathway Pathway_792 REACTOME_TGF_BETA_RECEPTOR_SIGNALING_IN_EMT_EPITHELIAL_TO_MESENCHYMAL_TRANSITION 0 0.75
Category members GO Category GO:0005923 tight junction Database 0.69
Category members GO Category GO:0007049 cell cycle Database 0.69
Category members Pathway Pathway_509 SIG_INSULIN_RECEPTOR_PATHWAY_IN_CARDIAC_MYOCYTES 0 0.62
Category members GO Category GO:0006461 protein complex assembly Database 0.57
Category members GO Category GO:0000226 microtubule cytoskeleton organization Database 0.5
Category members Pathway Pathway_747 KEGG_ADHERENS_JUNCTION 0 0.43
Category members GO Category GO:0005819 spindle Database 0.41
Category members GO Category GO:0007205 protein kinase C-activating G-protein coupled receptor signaling pathway Database 0.36
Category members GO Category GO:0070830 tight junction assembly Database 0.36
Category members GO Category GO:0019903 protein phosphatase binding Database 0.33
Category members GO Category GO:0006612 protein targeting to membrane Database 0.29
Category members GO Category GO:0034329 cell junction assembly Database 0.29
Category members Pathway Pathway_560 REACTOME_CELL_CELL_COMMUNICATION 0 0.25
Category members GO Category GO:0005912 adherens junction Database 0.25
Category members GO Category GO:0007179 transforming growth factor beta receptor signaling pathway Database 0.25
Category members Pathway Pathway_165 SIG_PIP3_SIGNALING_IN_CARDIAC_MYOCTES 0 0.18
Category members GO Category GO:0007409 axonogenesis Database 0.13
Category members GO Category GO:0045216 cell-cell junction organization Database 0.1
Category members GO Category GO:0005546 phosphatidylinositol-4,5-bisphosphate binding Database 0.09
Category members GO Category GO:0008356 asymmetric cell division Database 0.05
Category members GO Category GO:0005547 phosphatidylinositol-3,4,5-trisphosphate binding Database 0.04
Category members GO Category GO:0005080 protein kinase C binding Database 0.04
Category members Pathway Pathway_1236 REACTOME_TIGHT_JUNCTION_INTERACTIONS 0 0
Category members Pathway Pathway_1237 REACTOME_CELL_CELL_JUNCTION_ORGANIZATION 0 0
Category members Pathway Pathway_252 KEGG_CHEMOKINE_SIGNALING_PATHWAY 0 0
Category members Pathway Pathway_925 REACTOME_CELL_JUNCTION_ORGANIZATION 0 0
Category members GO Category GO:0003383 apical constriction Database 0
Category members GO Category GO:0012505 endomembrane system Database 0
Category members GO Category GO:0030054 cell junction Database 0
Category members GO Category GO:0032266 phosphatidylinositol-3-phosphate binding Database 0
Category members GO Category GO:0032970 regulation of actin filament-based process Database 0
Category members GO Category GO:0043025 neuronal cell body Database 0
Category members GO Category GO:0044295 axonal growth cone Database 0
Category members GO Category GO:0044319 wound healing, spreading of cells Database 0
Category members GO Category GO:0045177 apical part of cell Database 0
Category members GO Category GO:0051642 centrosome localization Database 0


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