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Query: OPA1

RNAi screen result RNAPII IP (PI) CSB IP CSB IP (PI) Chrom. Chrom. (PI) Phosphorylation Ubiquitylation
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[Click on the plots to view the data selection in the respective scatterplot]

Protein Results:

 Results for post-translational modifications: see below | Red/green: hit at lower/upper end of the respective screen
Gene name Point score Z-score sums RNAi high RNAi low RNAPII-IP (PI) CSB-IP CSB-IP (PI) Chrom. Chrom. (PI)
OPA1 0 4.002 -0.940 1.320 0.057 -0.292
OPA1 0 4.002 -0.940 1.320 0.962 0.828 0.737

PTM Sites:

 Back to Protein Results | Red/green: hit at lower/upper end of the respective screen
Gene name PTM type PTM site UV UV (PI) Sequence
OPA1 Ubiquitylation K261 0.390 _AAGQYSTSYAQQK(gl)R_

Background Information for OPA1:


Pubmed-OPA1 »
Uniprot-OPA1 »
Biogrid-OPA1 »
ProteomicsDB-OPA1 »

Tumorportal-OPA1 »
COSMIC-OPA1 »
GenomeRNAi-OPA1 »
Genecards-OPA1


Protein-protein Interactions for OPA1
Show screen data for Category Name and Description Link to cat description Data Source
Category members IP bait CYR61 Cat. description Hein, Mann, Cell 2015
Category members IP bait XRCC3 Cat. description Hein, Mann, Cell 2015
Category members IP bait EPHA1 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait FAM174A Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait FAM196A Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait NPY2R Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait PRDX3 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait PTH1R Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait SCGN Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait SCN2B Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait VIPR2 Cat. description BioPlex, Huttlin, Gygi, Cell 2015


Protein Domains in OPA1
Domain name Domain Description TC-NER relevance -log10(p-value)
Category members P-loop_NTPase IPR027417 2.83
Category members Dynamin_GTPase IPR001401 0.36
Category members Dynamin_SF IPR022812 0.11


Protein complexes (CORUM database) featuring OPA1
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)
Category members Corum 5450 Mediator complex Database 0.45


Categories featuring OPA1
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)
Category members GO Category GO:0005515 protein binding Database INF
Category members GO Category GO:0016021 integral to membrane Database 7.67
Category members GO Category GO:0006915 apoptotic process Database 2.12
Category members GO Category GO:0005739 mitochondrion Database 1.67
Category members GO Category GO:0005741 mitochondrial outer membrane Database 0.46
Category members GO Category GO:0005758 mitochondrial intermembrane space Database 0.33
Category members GO Category GO:0030061 mitochondrial crista Database 0.31
Category members GO Category GO:0006184 GTP catabolic process Database 0.29
Category members GO Category GO:0007007 inner mitochondrial membrane organization Database 0.28
Category members Disease phenotype Autosomal_dominant_optic_atrophy_plus_syndrome Autosomal dominant optic atrophy plus syndrome Database 0.28
Category members GO Category GO:0008053 mitochondrial fusion Database 0.27
Category members GO Category GO:0030425 dendrite Database 0.26
Category members GO Category GO:0005525 GTP binding Database 0.16
Category members GO Category GO:0003924 GTPase activity Database 0.16
Category members GO Category GO:0005743 mitochondrial inner membrane Database 0.15
Category members GO Category GO:0000266 mitochondrial fission Database 0
Category members GO Category GO:0000287 magnesium ion binding Database 0
Category members GO Category GO:0001843 neural tube closure Database 0
Category members GO Category GO:0007005 mitochondrion organization Database 0
Category members GO Category GO:0007601 visual perception Database 0
Category members GO Category GO:0019896 axon transport of mitochondrion Database 0


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