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Query: NCL

RNAi screen result RNAPII IP (PI) CSB IP CSB IP (PI) Chrom. Chrom. (PI) Phosphorylation Ubiquitylation
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[Click on the plots to view the data selection in the respective scatterplot]

Protein Results:

 Results for post-translational modifications: see below | Red/green: hit at lower/upper end of the respective screen
Gene name Point score Z-score sums RNAi high RNAi low RNAPII-IP (PI) CSB-IP CSB-IP (PI) Chrom. Chrom. (PI)
NCL 3 6.370 -0.530 0.500 -0.279 -0.044 0.135

PTM Sites:

 Back to Protein Results | Red/green: hit at lower/upper end of the respective screen
Gene name PTM type PTM site UV UV (PI) Sequence
NCL Phosphorylation S619 1.522 1.942 _GFGFVDFNS(ph)EEDAK_
NCL Ubiquitylation K398 0.982 1.070 _TLLAK(gl)NLPYK_
NCL Phosphorylation S580 1.509 0.943 _GLS(ph)EDTTEETLK_
NCL Phosphorylation T69 0.262 0.250 _KVVVSPT(ph)KK_
NCL Phosphorylation S67 0.084 0.215 _VVVS(ph)PTKK_
NCL Phosphorylation S563 -0.006 0.046 _LELQGPRGS(ph)PNAR_
NCL Ubiquitylation K513 1.291 -0.285 _ATFIK(gl)VPQNQNGK_
NCL Phosphorylation T121 -0.434 -0.594 _ALVAT(ph)PGKK_
NCL Phosphorylation T76 -0.311 -1.653 _KVAVAT(ph)PAK_
NCL Ubiquitylation K70 0.073 _KVVVSPTK(gl)K_
NCL Ubiquitylation K71 0.073 _KVVVSPTK(gl)K_
NCL Ubiquitylation K102 0.229 _TVTPAK(gl)AVTTPGKK_
NCL Ubiquitylation K116 0.184 _GATPGK(gl)ALVATPGKK_
NCL Ubiquitylation K135 0.162 _GAAIPAKGAK(gl)_
NCL Ubiquitylation K324 1.129 _SAPELK(gl)TGISDVFAK_
NCL Ubiquitylation K333 1.065 _TGISDVFAK(gl)NDLAVVDVR_
NCL Ubiquitylation K377 0.914 _VFGNEIK(gl)LEKPK_
NCL Ubiquitylation K380 1.047 _VFGNEIKLEK(gl)PK_
NCL Ubiquitylation K403 1.073 _NLPYK(gl)VTQDELK_
NCL Ubiquitylation K429 1.523 _SK(gl)GIAYIEFK_
NCL Ubiquitylation K467 1.082 _SISLYYTGEK(gl)GQNQDYR_
NCL Ubiquitylation K589 0.843 _GLSEDTTEETLK(gl)ESFDGSVR_

Background Information for NCL:


Pubmed-NCL »
Uniprot-NCL »
Biogrid-NCL »
ProteomicsDB-NCL »

Tumorportal-NCL »
COSMIC-NCL »
GenomeRNAi-NCL »
Genecards-NCL


Protein-protein Interactions for NCL
Show screen data for Category Name and Description Link to cat description Data Source
Category members IP bait AKAP5 Cat. description Hein, Mann, Cell 2015
Category members IP bait CBX1 Cat. description Hein, Mann, Cell 2015
Category members IP bait EXOSC2 Cat. description Hein, Mann, Cell 2015
Category members IP bait NOP9 Cat. description Hein, Mann, Cell 2015
Category members IP bait SRP72 Cat. description Hein, Mann, Cell 2015
Category members IP bait EBNA1BP2 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait NCL Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait NPM1 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait RPL28 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait RPL37A Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait RRS1 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait WDR46 Cat. description BioPlex, Huttlin, Gygi, Cell 2015


Protein Domains in NCL
Domain name Domain Description TC-NER relevance -log10(p-value)
Category members ARM-type_fold IPR016024 9.26
Category members RRM_dom IPR000504 4.34
Category members RRM_dom_euk IPR003954 0.18


Protein complexes (CORUM database) featuring NCL
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)
Category members Corum 3055 Nop56p-associated pre-rRNA complex Database INF
Category members Corum 1191 RNA pol II containing coactivator complex Tat-SF Database 2.13
Category members Corum 3135 TLE1 corepressor complex (MASH1 promoter-corepressor complex) Database 1.58
Category members Corum 1729 TLE1 corepressor complex (MASH1 promoter-corepressor complex) Database 1.02
Category members Corum 2599 POLR2A-CCNT1-CDK9-NCL-LEM6-CPSF2 complex Database 0.75
Category members Corum 3082 DGCR8 multiprotein complex Database 0.07
Category members Corum 3078 DGCR8-NCL complex Database 0.04
Category members Corum 92 CD28-transactivation complex Database 0


Categories featuring NCL
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)
Category members DDR Literature pubmedid:24332808 Marechal et al., 2014 RPA-mediated recruitment INF
Category members GO Category GO:0003723 RNA binding Database INF
Category members GO Category GO:0005515 protein binding Database INF
Category members GO Category GO:0005634 nucleus Database INF
Category members GO Category GO:0005654 nucleoplasm Database INF
Category members GO Category GO:0005730 nucleolus Database 13.38
Category members DDR Literature pubmedid:TBD1_UV_decreased Elia et al, 2015 UV decreased acetylation events Elia et al. 10.54
Category members GO Category GO:0005488 binding Database 9.32
Category members GO Category GO:0030529 ribonucleoprotein complex Database 8.45
Category members GO Category GO:0000166 nucleotide binding Database 5.91
Category members Pathway Pathway_881 PID_TELOMERASE_PATHWAY 0 2.64
Category members GO Category GO:0005938 cell cortex Database 2.26
Category members GO Category GO:0008022 protein C-terminus binding Database 1.43
Category members GO Category GO:0042162 telomeric DNA binding Database 1.23
Category members Pathway Pathway_65 PID_MYC_ACTIV_PATHWAY 0 1.08
Category members GO Category GO:0003676 nucleic acid binding Database 0.83
Category members Pathway Pathway_402 BIOCARTA_SARS_PATHWAY 0 0.64
Category members Pathway Pathway_911 PID_AURORA_B_PATHWAY 0 0.48
Category members Pathway Pathway_1026 KEGG_PATHOGENIC_ESCHERICHIA_COLI_INFECTION 0 0.45
Category members GO Category GO:0042802 identical protein binding Database 0.26
Category members Pathway Pathway_710 PID_UPA_UPAR_PATHWAY 0 0.2
Category members GO Category GO:0001525 angiogenesis Database 0


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