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Query: MTDH

RNAi screen result RNAPII IP (PI) CSB IP CSB IP (PI) Chrom. Chrom. (PI) Phosphorylation Ubiquitylation
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[Click on the plots to view the data selection in the respective scatterplot]

Protein Results:

 Results for post-translational modifications: see below | Red/green: hit at lower/upper end of the respective screen
Gene name Point score Z-score sums RNAi high RNAi low RNAPII-IP (PI) CSB-IP CSB-IP (PI) Chrom. Chrom. (PI)
MTDH 2 5.915 0.690 -0.240 0.222 0.258

PTM Sites:

 Back to Protein Results | Red/green: hit at lower/upper end of the respective screen
Gene name PTM type PTM site UV UV (PI) Sequence
MTDH Phosphorylation S298 3.215 2.229 _LSSQIS(ph)AGEEK_
MTDH Phosphorylation S426 0.024 0.054 _SQEPIPDDQKVS(ph)DDDKEK_
MTDH Phosphorylation S308 -1.181 -0.077 _WNSVS(ph)PASAGK_
MTDH Phosphorylation T143 -0.168 _TVEVAEGEAVRT(ph)PQSVTAK_
MTDH Phosphorylation S568 -1.097 -0.503 _SETSWES(ph)PK_
MTDH Ubiquitylation K504 -0.009 _TISTSDPAEVLVK(gl)NSQPIK_

Background Information for MTDH:


Pubmed-MTDH »
Uniprot-MTDH »
Biogrid-MTDH »
ProteomicsDB-MTDH »

Tumorportal-MTDH »
COSMIC-MTDH »
GenomeRNAi-MTDH »
Genecards-MTDH


Protein-protein Interactions for MTDH
Show screen data for Category Name and Description Link to cat description Data Source
Category members IP bait EXOSC4 Cat. description Hein, Mann, Cell 2015
Category members IP bait RPL35 Cat. description Hein, Mann, Cell 2015
Category members IP bait MTDH Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait MTUS2 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait NR2E1 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait SIRT2 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait SNN Cat. description BioPlex, Huttlin, Gygi, Cell 2015


Protein Domains in MTDH
Domain name Domain Description TC-NER relevance -log10(p-value)


Protein complexes (CORUM database) featuring MTDH
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)


Categories featuring MTDH
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)
Category members GO Category GO:0005515 protein binding Database INF
Category members GO Category GO:0005634 nucleus Database INF
Category members GO Category GO:0005730 nucleolus Database 13.38
Category members GO Category GO:0005737 cytoplasm Database 12.81
Category members GO Category GO:0016021 integral to membrane Database 7.67
Category members GO Category GO:0003713 transcription coactivator activity Database 3.68
Category members GO Category GO:0031965 nuclear membrane Database 2.59
Category members GO Category GO:0005789 endoplasmic reticulum membrane Database 1.57
Category members Pathway Pathway_65 PID_MYC_ACTIV_PATHWAY 0 1.08
Category members GO Category GO:0005923 tight junction Database 0.69
Category members GO Category GO:0005783 endoplasmic reticulum Database 0.62
Category members GO Category GO:0043066 negative regulation of apoptotic process Database 0.6
Category members GO Category GO:0048471 perinuclear region of cytoplasm Database 0.39
Category members GO Category GO:0070830 tight junction assembly Database 0.36
Category members GO Category GO:0051059 NF-kappaB binding Database 0.25
Category members GO Category GO:0045766 positive regulation of angiogenesis Database 0.19
Category members GO Category GO:0046581 intercellular canaliculus Database 0.15
Category members GO Category GO:0003725 double-stranded RNA binding Database 0.1
Category members GO Category GO:0016604 nuclear body Database 0.04
Category members GO Category GO:0000122 negative regulation of transcription from RNA polymerase II promoter Database 0.02
Category members GO Category GO:0001085 RNA polymerase II transcription factor binding Database 0
Category members GO Category GO:0010508 positive regulation of autophagy Database 0
Category members GO Category GO:0016324 apical plasma membrane Database 0
Category members GO Category GO:0031663 lipopolysaccharide-mediated signaling pathway Database 0
Category members GO Category GO:0043123 positive regulation of I-kappaB kinase/NF-kappaB signaling Database 0
Category members GO Category GO:0051092 positive regulation of NF-kappaB transcription factor activity Database 0
Category members GO Category GO:0051897 positive regulation of protein kinase B signaling Database 0


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