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Query: MAPT

RNAi screen result RNAPII IP (PI) CSB IP CSB IP (PI) Chrom. Chrom. (PI) Phosphorylation Ubiquitylation
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[Click on the plots to view the data selection in the respective scatterplot]

Protein Results:

 Results for post-translational modifications: see below | Red/green: hit at lower/upper end of the respective screen
Gene name Point score Z-score sums RNAi high RNAi low RNAPII-IP (PI) CSB-IP CSB-IP (PI) Chrom. Chrom. (PI)
MAPT 0 0.065 -0.190 0.150

PTM Sites:

 Back to Protein Results | Red/green: hit at lower/upper end of the respective screen
Gene name PTM type PTM site UV UV (PI) Sequence
MAPT Phosphorylation T720 -0.287 0.006 _SPVVSGDT(ph)SPR_
MAPT Phosphorylation S733 -0.413 -0.151 _HLSNVSSTGS(ph)IDMVDSPQLATLADEVSASLAK_
MAPT Phosphorylation S729 -0.160 _HLSNVS(ph)STGSIDMVDSPQLATLADEVSASLAK_
MAPT Phosphorylation S717 -0.091 -0.193 _SPVVS(ph)GDTSPR_
MAPT Phosphorylation S721 -0.091 -0.203 _SPVVSGDTS(ph)PR_
MAPT Phosphorylation S552 -0.811 -0.801 _VAVVRT(ph)PPKS(ph)PSSAK_
MAPT Phosphorylation T548 -0.976 -0.803 _VAVVRT(ph)PPKS(ph)PSSAK_
MAPT Phosphorylation S519 -0.792 -1.278 _SGYSSPGS(ph)PGTPGSR_
MAPT Phosphorylation S437 -2.106 -1.602 _HPTPGSSDPLIQPSSPAVCPEPPS(ph)SPK_
MAPT Phosphorylation S438 -2.106 -1.602 _HPTPGSSDPLIQPSSPAVCPEPPS(ph)SPK_
MAPT Phosphorylation S516 -0.589 _SGYSS(ph)PGSPGTPGSR_

Background Information for MAPT:


Pubmed-MAPT »
Uniprot-MAPT »
Biogrid-MAPT »
ProteomicsDB-MAPT »

Tumorportal-MAPT »
COSMIC-MAPT »
GenomeRNAi-MAPT »
Genecards-MAPT


Protein-protein Interactions for MAPT
Show screen data for Category Name and Description Link to cat description Data Source
Category members IP bait BAG6;BAT3 Cat. description Hein, Mann, Cell 2015
Category members IP bait CKAP5 Cat. description Hein, Mann, Cell 2015
Category members IP bait GAR1 Cat. description Hein, Mann, Cell 2015
Category members IP bait GTF2E2 Cat. description Hein, Mann, Cell 2015
Category members IP bait KATNA1 Cat. description Hein, Mann, Cell 2015
Category members IP bait KIFC3 Cat. description Hein, Mann, Cell 2015
Category members IP bait MAPT Cat. description Hein, Mann, Cell 2015
Category members IP bait SLC6A8 Cat. description Hein, Mann, Cell 2015
Category members IP bait SYNCRIP Cat. description Hein, Mann, Cell 2015
Category members IP bait TFEB Cat. description Hein, Mann, Cell 2015
Category members IP bait TIGD6 Cat. description Hein, Mann, Cell 2015
Category members IP bait USP43 Cat. description Hein, Mann, Cell 2015
Category members IP bait ARMC1 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait C14orf104 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait CDCA8 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait DGUOK Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait HAX1 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait HSPA8 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait MAPT Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait NUFIP1 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait RRP7A Cat. description BioPlex, Huttlin, Gygi, Cell 2015


Protein Domains in MAPT
Domain name Domain Description TC-NER relevance -log10(p-value)
Category members MAP_tubulin-bd_rpt IPR001084 0


Protein complexes (CORUM database) featuring MAPT
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)


Categories featuring MAPT
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)
Category members GO Category GO:0005515 protein binding Database INF
Category members GO Category GO:0005634 nucleus Database INF
Category members GO Category GO:0005829 cytosol Database INF
Category members GO Category GO:0005737 cytoplasm Database 12.81
Category members GO Category GO:0006921 cellular component disassembly involved in execution phase of apoptosis Database 2.98
Category members Pathway Pathway_876 REACTOME_APOPTOTIC_EXECUTION_PHASE 0 2.5
Category members Pathway Pathway_837 REACTOME_APOPTOSIS 0 2.39
Category members GO Category GO:0006915 apoptotic process Database 2.12
Category members GO Category GO:0030426 growth cone Database 1.61
Category members GO Category GO:0019899 enzyme binding Database 1.57
Category members GO Category GO:0034399 nuclear periphery Database 1.34
Category members Pathway Pathway_877 REACTOME_APOPTOTIC_CLEAVAGE_OF_CELLULAR_PROTEINS 0 1.25
Category members GO Category GO:0005874 microtubule Database 1.21
Category members GO Category GO:0005886 plasma membrane Database 1.21
Category members Pathway Pathway_237 PID_LYSOPHOSPHOLIPID_PATHWAY 0 1.09
Category members GO Category GO:0015631 tubulin binding Database 0.83
Category members GO Category GO:0008017 microtubule binding Database 0.79
Category members Pathway Pathway_1142 PID_LKB1_PATHWAY 0 0.6
Category members GO Category GO:0000226 microtubule cytoskeleton organization Database 0.5
Category members GO Category GO:0019901 protein kinase binding Database 0.37
Category members GO Category GO:0030424 axon Database 0.23
Category members GO Category GO:0047497 mitochondrion transport along microtubule Database 0.23
Category members Pathway Pathway_1141 BIOCARTA_P35ALZHEIMERS_PATHWAY 0 0.19
Category members GO Category GO:0007409 axonogenesis Database 0.13
Category members Pathway Pathway_1018 REACTOME_CASPASE_MEDIATED_CLEAVAGE_OF_CYTOSKELETAL_PROTEINS 0 0.11
Category members GO Category GO:0031113 regulation of microtubule polymerization Database 0.1
Category members GO Category GO:0048699 generation of neurons Database 0.04
Category members Disease phenotype Behavioral_variant_of_frontotemporal_dementia Behavioral variant of frontotemporal dementia Database 0.04
Category members Disease phenotype Progressive_non-fluent_aphasia Progressive non-fluent aphasia Database 0.04
Category members Disease phenotype Semantic_dementia Semantic dementia Database 0.04
Category members GO Category GO:0048675 axon extension Database 0.01
Category members Pathway Pathway_558 PID_REELIN_PATHWAY 0 0.01
Category members GO Category GO:0005875 microtubule associated complex Database 0
Category members Pathway Pathway_1129 PID_P38_GAMMA_DELTA_PATHWAY 0 0
Category members Pathway Pathway_29 KEGG_ALZHEIMERS_DISEASE 0 0
Category members Pathway Pathway_704 BIOCARTA_BIOPEPTIDES_PATHWAY 0 0
Category members Pathway Pathway_715 KEGG_MAPK_SIGNALING_PATHWAY 0 0
Category members Disease phenotype FRONTOTEMPORAL_DEMENTIA FRONTOTEMPORAL DEMENTIA Database 0
Category members GO Category GO:0001764 neuron migration Database 0
Category members GO Category GO:0005200 structural constituent of cytoskeleton Database 0
Category members GO Category GO:0007628 adult walking behavior Database 0
Category members GO Category GO:0008088 axon cargo transport Database 0
Category members GO Category GO:0010506 regulation of autophagy Database 0
Category members GO Category GO:0017124 SH3 domain binding Database 0
Category members GO Category GO:0031116 positive regulation of microtubule polymerization Database 0
Category members GO Category GO:0032387 negative regulation of intracellular transport Database 0
Category members GO Category GO:0034185 apolipoprotein binding Database 0
Category members GO Category GO:0045298 tubulin complex Database 0
Category members GO Category GO:0045773 positive regulation of axon extension Database 0
Category members GO Category GO:0060632 regulation of microtubule-based movement Database 0


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