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Query: JAG2

RNAi screen result RNAPII IP (PI) CSB IP CSB IP (PI) Chrom. Chrom. (PI) Phosphorylation Ubiquitylation
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[Click on the plots to view the data selection in the respective scatterplot]

Protein Results:

 Results for post-translational modifications: see below | Red/green: hit at lower/upper end of the respective screen
Gene name Point score Z-score sums RNAi high RNAi low RNAPII-IP (PI) CSB-IP CSB-IP (PI) Chrom. Chrom. (PI)
JAG2 0 0.348 -0.170 0.020

PTM Sites:

 Back to Protein Results | Red/green: hit at lower/upper end of the respective screen
Gene name PTM type PTM site UV UV (PI) Sequence
JAG2 Ubiquitylation K76 1.283 _VCLK(gl)EYQAK_
JAG2 Phosphorylation T1155 -0.335 -0.737 _NFT(ph)PPPR_
JAG2 Ubiquitylation K1200 0.117 _FLSHK(gl)FTK_

Background Information for JAG2:


Pubmed-JAG2 »
Uniprot-JAG2 »
Biogrid-JAG2 »
ProteomicsDB-JAG2 »

Tumorportal-JAG2 »
COSMIC-JAG2 »
GenomeRNAi-JAG2 »
Genecards-JAG2


Protein-protein Interactions for JAG2
Show screen data for Category Name and Description Link to cat description Data Source
Category members IP bait ADAM32 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait ATP1B4 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait LPPR1 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait STS Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait TCTN2 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait TMEM30B Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait UST Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait VASN Cat. description BioPlex, Huttlin, Gygi, Cell 2015


Protein Domains in JAG2
Domain name Domain Description TC-NER relevance -log10(p-value)
Category members EG-like_dom IPR000742 1.74
Category members EGF-like_Ca-bd_dom IPR001881 0.69
Category members EGF_extracell IPR013111 0.46
Category members DSL IPR001774 0.05
Category members Notch_ligand_N IPR011651 0.05
Category members VWF_C IPR001007 0.04
Category members VWC_out IPR006552 0


Protein complexes (CORUM database) featuring JAG2
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)


Categories featuring JAG2
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)
Category members GO Category GO:0005515 protein binding Database INF
Category members GO Category GO:0016021 integral to membrane Database 7.67
Category members DDR Literature pubmedid:19647519 Paulsen et al., 2009 siRNA screen for g-H2A.x phosphorylation 3.6
Category members GO Category GO:0008083 growth factor activity Database 2.34
Category members GO Category GO:0005887 integral to plasma membrane Database 1.69
Category members GO Category GO:0005886 plasma membrane Database 1.21
Category members GO Category GO:0042981 regulation of apoptotic process Database 0.79
Category members GO Category GO:0007049 cell cycle Database 0.69
Category members GO Category GO:0030334 regulation of cell migration Database 0.61
Category members GO Category GO:0016020 membrane Database 0.52
Category members Pathway Pathway_117 REACTOME_SIGNALING_BY_NOTCH 0 0.33
Category members GO Category GO:0007275 multicellular organismal development Database 0.31
Category members Pathway Pathway_849 PID_NOTCH_PATHWAY 0 0.29
Category members Pathway Pathway_789 REACTOME_SIGNALING_BY_NOTCH1 0 0.22
Category members GO Category GO:0001701 in utero embryonic development Database 0.2
Category members GO Category GO:0003016 respiratory system process Database 0.17
Category members GO Category GO:0005112 Notch binding Database 0.14
Category members Pathway Pathway_200 PID_P73PATHWAY 0 0.11
Category members GO Category GO:0005509 calcium ion binding Database 0.11
Category members GO Category GO:0030154 cell differentiation Database 0.06
Category members GO Category GO:0042127 regulation of cell proliferation Database 0.06
Category members GO Category GO:0007219 Notch signaling pathway Database 0.05
Category members Pathway Pathway_815 REACTOME_RECEPTOR_LIGAND_BINDING_INITIATES_THE_SECOND_PROTEOLYTIC_CLEAVAGE_OF_NOTCH_RECEPTOR 0 0.03
Category members Pathway Pathway_1278 REACTOME_SIGNALING_BY_NOTCH2 0 0
Category members Pathway Pathway_1279 REACTOME_SIGNALING_BY_NOTCH3 0 0
Category members Pathway Pathway_1280 REACTOME_SIGNALING_BY_NOTCH4 0 0
Category members Pathway Pathway_831 REACTOME_ACTIVATED_NOTCH1_TRANSMITS_SIGNAL_TO_THE_NUCLEUS 0 0
Category members Pathway Pathway_892 KEGG_NOTCH_SIGNALING_PATHWAY 0 0
Category members GO Category GO:0001501 skeletal system development Database 0
Category members GO Category GO:0007154 cell communication Database 0
Category members GO Category GO:0007220 Notch receptor processing Database 0
Category members GO Category GO:0007283 spermatogenesis Database 0
Category members GO Category GO:0009912 auditory receptor cell fate commitment Database 0
Category members GO Category GO:0016331 morphogenesis of embryonic epithelium Database 0
Category members GO Category GO:0030155 regulation of cell adhesion Database 0
Category members GO Category GO:0030217 T cell differentiation Database 0
Category members GO Category GO:0042475 odontogenesis of dentin-containing tooth Database 0
Category members GO Category GO:0045061 thymic T cell selection Database 0


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