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Query: IMPDH2

RNAi screen result RNAPII IP (PI) CSB IP CSB IP (PI) Chrom. Chrom. (PI) Phosphorylation Ubiquitylation
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[Click on the plots to view the data selection in the respective scatterplot]

Protein Results:

 Results for post-translational modifications: see below | Red/green: hit at lower/upper end of the respective screen
Gene name Point score Z-score sums RNAi high RNAi low RNAPII-IP (PI) CSB-IP CSB-IP (PI) Chrom. Chrom. (PI)
IMPDH2 0 8.042 -1.000 1.830 0.860 0.260 0.421 1.006 0.467

PTM Sites:

 Back to Protein Results | Red/green: hit at lower/upper end of the respective screen
Gene name PTM type PTM site UV UV (PI) Sequence
IMPDH2 Phosphorylation S160 0.758 0.744 _LVGIISS(ph)R_
IMPDH2 Phosphorylation S416 0.362 0.652 _GMGS(ph)LDAMDK_
IMPDH2 Ubiquitylation K422 1.114 0.582 _GMGSLDAMDK(gl)HLSSQNR_
IMPDH2 Ubiquitylation K450 0.313 0.467 _VAQGVSGAVQDK(gl)GSIHK_
IMPDH2 Ubiquitylation K134 0.709 0.285 _VRDVFEAK(gl)AR_
IMPDH2 Ubiquitylation K208 -0.482 -0.007 _GK(gl)LPIVNEDDELVAIIAR_
IMPDH2 Ubiquitylation K124 0.058 _YEQGFITDPVVLSPK(gl)DR_
IMPDH2 Ubiquitylation K293 0.119 _DK(gl)YPNLQVIGGNVVTAAQAK_

Background Information for IMPDH2:


Pubmed-IMPDH2 »
Uniprot-IMPDH2 »
Biogrid-IMPDH2 »
ProteomicsDB-IMPDH2 »

Tumorportal-IMPDH2 »
COSMIC-IMPDH2 »
GenomeRNAi-IMPDH2 »
Genecards-IMPDH2


Protein-protein Interactions for IMPDH2
Show screen data for Category Name and Description Link to cat description Data Source
Category members IP bait AP4M1 Cat. description Hein, Mann, Cell 2015
Category members IP bait BMPR1A Cat. description Hein, Mann, Cell 2015
Category members IP bait EMC2 Cat. description Hein, Mann, Cell 2015
Category members IP bait ENTHD2 Cat. description Hein, Mann, Cell 2015
Category members IP bait JUNB Cat. description Hein, Mann, Cell 2015
Category members IP bait MMGT1 Cat. description Hein, Mann, Cell 2015
Category members IP bait MYO1C Cat. description Hein, Mann, Cell 2015
Category members IP bait NES Cat. description Hein, Mann, Cell 2015
Category members IP bait SEC16A Cat. description Hein, Mann, Cell 2015
Category members IP bait XRCC3 Cat. description Hein, Mann, Cell 2015
Category members IP bait IMPDH2 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait SKP2 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait SLC25A44 Cat. description BioPlex, Huttlin, Gygi, Cell 2015


Protein Domains in IMPDH2
Domain name Domain Description TC-NER relevance -log10(p-value)
Category members 2Npropane_dOase IPR004136 0.28
Category members IMP_DH IPR005990 0.28
Category members FMN-dep_DH IPR000262 0
Category members CBS_dom IPR000644 0
Category members IMP_DH_GMPRt IPR001093 0


Protein complexes (CORUM database) featuring IMPDH2
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)


Categories featuring IMPDH2
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)
Category members DDR Literature pubmedid:24332808 Marechal et al., 2014 RPA-mediated recruitment INF
Category members GO Category GO:0003723 RNA binding Database INF
Category members GO Category GO:0005634 nucleus Database INF
Category members GO Category GO:0005829 cytosol Database INF
Category members GO Category GO:0005737 cytoplasm Database 12.81
Category members GO Category GO:0000166 nucleotide binding Database 5.91
Category members GO Category GO:0003677 DNA binding Database 1.53
Category members GO Category GO:0051289 protein homotetramerization Database 0.44
Category members GO Category GO:0044281 small molecule metabolic process Database 0.35
Category members GO Category GO:0006177 GMP biosynthetic process Database 0.29
Category members GO Category GO:0003938 IMP dehydrogenase activity Database 0.28
Category members GO Category GO:0018580 nitronate monooxygenase activity Database 0.28
Category members Pathway Pathway_273 REACTOME_PURINE_RIBONUCLEOSIDE_MONOPHOSPHATE_BIOSYNTHESIS 0 0.23
Category members Pathway Pathway_68 KEGG_PURINE_METABOLISM 0 0.23
Category members Pathway Pathway_204 REACTOME_PURINE_METABOLISM 0 0.22
Category members GO Category GO:0071353 cellular response to interleukin-4 Database 0.19
Category members GO Category GO:0009168 purine ribonucleoside monophosphate biosynthetic process Database 0.12
Category members GO Category GO:0006144 purine nucleobase metabolic process Database 0.11
Category members GO Category GO:0003824 catalytic activity Database 0.11
Category members GO Category GO:0005778 peroxisomal membrane Database 0.01
Category members Pathway Pathway_206 REACTOME_METABOLISM_OF_NUCLEOTIDES 0 0
Category members Pathway Pathway_77 KEGG_DRUG_METABOLISM_OTHER_ENZYMES 0 0
Category members GO Category GO:0006051 N-acetylmannosamine metabolic process Database 0
Category members GO Category GO:0006164 purine nucleotide biosynthetic process Database 0
Category members GO Category GO:0016491 oxidoreductase activity Database 0
Category members GO Category GO:0030554 adenyl nucleotide binding Database 0
Category members GO Category GO:0046651 lymphocyte proliferation Database 0
Category members GO Category GO:0046872 metal ion binding Database 0
Category members GO Category GO:0055086 nucleobase-containing small molecule metabolic process Database 0
Category members GO Category GO:0055114 oxidation-reduction process Database 0
Category members GO Category GO:0060041 retina development in camera-type eye Database 0


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