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Query: IMPDH1

RNAi screen result RNAPII IP (PI) CSB IP CSB IP (PI) Chrom. Chrom. (PI) Phosphorylation Ubiquitylation
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[Click on the plots to view the data selection in the respective scatterplot]

Protein Results:

 Results for post-translational modifications: see below | Red/green: hit at lower/upper end of the respective screen
Gene name Point score Z-score sums RNAi high RNAi low RNAPII-IP (PI) CSB-IP CSB-IP (PI) Chrom. Chrom. (PI)
IMPDH1 2 3.116 -0.140 -0.120 0.626 0.542

PTM Sites:

 Back to Protein Results | Red/green: hit at lower/upper end of the respective screen
Gene name PTM type PTM site UV UV (PI) Sequence
IMPDH1 Ubiquitylation K327 2.285 1.616 _DSQK(gl)QLLCGAAVGTR_
IMPDH1 Ubiquitylation K507 0.433 _GMGSLDAMEK(gl)SSSSQKR_
IMPDH1 Ubiquitylation K293 0.154 0.299 _GK(gl)LPIVNDCDELVAIIAR_
IMPDH1 Ubiquitylation K535 0.179 -0.096 _IAQGVSGSIQDK(gl)GSIQK_
IMPDH1 Phosphorylation T6 -0.746 -1.087 _(ac)M(ox)EGPLT(ph)PPPLQGGGAAAVPEPGAR_
IMPDH1 Ubiquitylation K523 0.629 _YFSEGDKVK(gl)_

Background Information for IMPDH1:


Pubmed-IMPDH1 »
Uniprot-IMPDH1 »
Biogrid-IMPDH1 »
ProteomicsDB-IMPDH1 »

Tumorportal-IMPDH1 »
COSMIC-IMPDH1 »
GenomeRNAi-IMPDH1 »
Genecards-IMPDH1


Protein-protein Interactions for IMPDH1
Show screen data for Category Name and Description Link to cat description Data Source
Category members IP bait EMC2 Cat. description Hein, Mann, Cell 2015
Category members IP bait JUNB Cat. description Hein, Mann, Cell 2015
Category members IP bait LGALS3BP Cat. description Hein, Mann, Cell 2015
Category members IP bait MMGT1 Cat. description Hein, Mann, Cell 2015
Category members IP bait MYO1C Cat. description Hein, Mann, Cell 2015
Category members IP bait RPL35 Cat. description Hein, Mann, Cell 2015
Category members IP bait SEC16A Cat. description Hein, Mann, Cell 2015
Category members IP bait XRCC3 Cat. description Hein, Mann, Cell 2015
Category members IP bait GATA2 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait IMPDH1 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait IMPDH2 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait KLHL2 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait LRRC8E Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait METTL22 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait PODXL Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait SOST Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait ZNF704 Cat. description BioPlex, Huttlin, Gygi, Cell 2015


Protein Domains in IMPDH1
Domain name Domain Description TC-NER relevance -log10(p-value)
Category members 2Npropane_dOase IPR004136 0.28
Category members IMP_DH IPR005990 0.28
Category members FMN-dep_DH IPR000262 0
Category members CBS_dom IPR000644 0
Category members IMP_DH_GMPRt IPR001093 0


Protein complexes (CORUM database) featuring IMPDH1
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)


Categories featuring IMPDH1
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)
Category members GO Category GO:0003723 RNA binding Database INF
Category members GO Category GO:0005634 nucleus Database INF
Category members GO Category GO:0005829 cytosol Database INF
Category members GO Category GO:0005737 cytoplasm Database 12.81
Category members GO Category GO:0003677 DNA binding Database 1.53
Category members GO Category GO:0003676 nucleic acid binding Database 0.83
Category members GO Category GO:0044281 small molecule metabolic process Database 0.35
Category members Disease phenotype Leber_congenital_amaurosis Leber congenital amaurosis Database 0.29
Category members GO Category GO:0006177 GMP biosynthetic process Database 0.29
Category members GO Category GO:0003938 IMP dehydrogenase activity Database 0.28
Category members GO Category GO:0018580 nitronate monooxygenase activity Database 0.28
Category members Pathway Pathway_273 REACTOME_PURINE_RIBONUCLEOSIDE_MONOPHOSPHATE_BIOSYNTHESIS 0 0.23
Category members Pathway Pathway_68 KEGG_PURINE_METABOLISM 0 0.23
Category members Pathway Pathway_204 REACTOME_PURINE_METABOLISM 0 0.22
Category members GO Category GO:0009168 purine ribonucleoside monophosphate biosynthetic process Database 0.12
Category members GO Category GO:0006144 purine nucleobase metabolic process Database 0.11
Category members GO Category GO:0003824 catalytic activity Database 0.11
Category members Pathway Pathway_206 REACTOME_METABOLISM_OF_NUCLEOTIDES 0 0
Category members Pathway Pathway_77 KEGG_DRUG_METABOLISM_OTHER_ENZYMES 0 0
Category members Disease phenotype Retinitis_pigmentosa Retinitis pigmentosa Database 0
Category members GO Category GO:0006164 purine nucleotide biosynthetic process Database 0
Category members GO Category GO:0009409 response to cold Database 0
Category members GO Category GO:0016491 oxidoreductase activity Database 0
Category members GO Category GO:0030554 adenyl nucleotide binding Database 0
Category members GO Category GO:0046651 lymphocyte proliferation Database 0
Category members GO Category GO:0046872 metal ion binding Database 0
Category members GO Category GO:0055086 nucleobase-containing small molecule metabolic process Database 0
Category members GO Category GO:0055114 oxidation-reduction process Database 0
Category members GO Category GO:0060041 retina development in camera-type eye Database 0


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