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Query: IDH1

This is a cancer-associated gene according to the Broad and Sanger cancer gene census.

RNAi screen result RNAPII IP (PI) CSB IP CSB IP (PI) Chrom. Chrom. (PI) Phosphorylation Ubiquitylation
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[Click on the plots to view the data selection in the respective scatterplot]

Protein Results:

 Results for post-translational modifications: see below | Red/green: hit at lower/upper end of the respective screen
Gene name Point score Z-score sums RNAi high RNAi low RNAPII-IP (PI) CSB-IP CSB-IP (PI) Chrom. Chrom. (PI)
IDH1 1 2.019 0.390 -0.320 1.581 0.783

PTM Sites:

 Back to Protein Results | Red/green: hit at lower/upper end of the respective screen
Gene name PTM type PTM site UV UV (PI) Sequence
IDH1 Ubiquitylation K58 -0.442 0.097 _DATNDQVTK(gl)DAAEAIKK_

Background Information for IDH1:


Pubmed-IDH1 »
Uniprot-IDH1 »
Biogrid-IDH1 »
ProteomicsDB-IDH1 »

Tumorportal-IDH1 »
COSMIC-IDH1 »
GenomeRNAi-IDH1 »
Genecards-IDH1


Protein-protein Interactions for IDH1
Show screen data for Category Name and Description Link to cat description Data Source


Protein Domains in IDH1
Domain name Domain Description TC-NER relevance -log10(p-value)
Category members IsoPropMal-DH-like_dom IPR024084 0.68
Category members Isocitrate_DH_NADP IPR004790 0.13


Protein complexes (CORUM database) featuring IDH1
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)


Categories featuring IDH1
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)
Category members GO Category GO:0005829 cytosol Database INF
Category members GO Category GO:0005737 cytoplasm Database 12.81
Category members Human mutations Sanger_cancer_genes Sanger cancer genes Database 4.88
Category members Pathway Pathway_3 KEGG_CITRATE_CYCLE_TCA_CYCLE 0 3.83
Category members GO Category GO:0006099 tricarboxylic acid cycle Database 2.74
Category members Pathway Pathway_10 REACTOME_PYRUVATE_METABOLISM_AND_CITRIC_ACID_TCA_CYCLE 0 1.76
Category members GO Category GO:0005739 mitochondrion Database 1.67
Category members GO Category GO:0051287 NAD binding Database 1.6
Category members Human mutations Broad_cancer_genes Broad cancer genes (Lawrence et al., 2014) literature 1.14
Category members GO Category GO:0008585 female gonad development Database 0.64
Category members GO Category GO:0044281 small molecule metabolic process Database 0.35
Category members GO Category GO:0006102 isocitrate metabolic process Database 0.31
Category members GO Category GO:0016616 oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor Database 0.29
Category members GO Category GO:0005782 peroxisomal matrix Database 0.23
Category members Disease phenotype Giant_cell_glioblastoma Giant cell glioblastoma Database 0.14
Category members Disease phenotype Gliosarcoma Gliosarcoma Database 0.14
Category members Disease phenotype Maffucci_syndrome Maffucci syndrome Database 0.13
Category members GO Category GO:0004450 isocitrate dehydrogenase (NADP+) activity Database 0.13
Category members GO Category GO:0006097 glyoxylate cycle Database 0.13
Category members GO Category GO:0048545 response to steroid hormone Database 0.11
Category members Pathway Pathway_26 REACTOME_PEROXISOMAL_LIPID_METABOLISM 0 0.04
Category members Pathway Pathway_13 REACTOME_TCA_CYCLE_AND_RESPIRATORY_ELECTRON_TRANSPORT 0 0.04
Category members GO Category GO:0006740 NADPH regeneration Database 0.04
Category members Pathway Pathway_25 KEGG_PEROXISOME 0 0
Category members Pathway Pathway_27 KEGG_GLUTATHIONE_METABOLISM 0 0
Category members Pathway Pathway_4 REACTOME_METABOLISM_OF_LIPIDS_AND_LIPOPROTEINS 0 0
Category members Disease phenotype Enchondromatosis Enchondromatosis Database 0
Category members Disease phenotype GLIOMA_SUSCEPTIBILITY_1 GLIOMA SUSCEPTIBILITY 1 Database 0
Category members GO Category GO:0000287 magnesium ion binding Database 0
Category members GO Category GO:0005102 receptor binding Database 0
Category members GO Category GO:0005777 peroxisome Database 0
Category members GO Category GO:0006103 2-oxoglutarate metabolic process Database 0
Category members GO Category GO:0006749 glutathione metabolic process Database 0
Category members GO Category GO:0006979 response to oxidative stress Database 0
Category members GO Category GO:0014070 response to organic cyclic compound Database 0
Category members GO Category GO:0042803 protein homodimerization activity Database 0
Category members GO Category GO:0044255 cellular lipid metabolic process Database 0
Category members GO Category GO:0050661 NADP binding Database 0
Category members GO Category GO:0055114 oxidation-reduction process Database 0


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