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Query: GMPS

This is a cancer-associated gene according to the Sanger cancer gene census.

RNAi screen result RNAPII IP (PI) CSB IP CSB IP (PI) Chrom. Chrom. (PI) Phosphorylation Ubiquitylation
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[Click on the plots to view the data selection in the respective scatterplot]

Protein Results:

 Results for post-translational modifications: see below | Red/green: hit at lower/upper end of the respective screen
Gene name Point score Z-score sums RNAi high RNAi low RNAPII-IP (PI) CSB-IP CSB-IP (PI) Chrom. Chrom. (PI)
GMPS 0 2.124 -0.740 0.600 -0.533 -0.030 0.022 -0.466 -0.160

PTM Sites:

 Back to Protein Results | Red/green: hit at lower/upper end of the respective screen
Gene name PTM type PTM site UV UV (PI) Sequence
GMPS Phosphorylation S332 0.573 0.448 _TLNMTTS(ph)PEEK_
GMPS Ubiquitylation K289 -0.344 0.223 _K(gl)LGIQVK_
GMPS Ubiquitylation K182 0.575 0.078 _SGNIVAGIANESK(gl)K_
GMPS Ubiquitylation K183 0.652 0.078 _SGNIVAGIANESKK(gl)_
GMPS Ubiquitylation K120 0.343 _VFGGTVHK(gl)K_
GMPS Ubiquitylation K121 0.457 _VFGGTVHKK(gl)_
GMPS Ubiquitylation K165 1.104 _VADGFK(gl)VVAR_
GMPS Ubiquitylation K288 0.285 _ESQSVEEALK(gl)K_
GMPS Phosphorylation T330 -0.017 _TLNM(ox)T(ph)TSPEEK_
GMPS Phosphorylation T331 0.917 _TLNMTT(ph)SPEEK_
GMPS Ubiquitylation K457 -0.834 _VICAEEPYICK(gl)DFPETNNILK_

Background Information for GMPS:


Pubmed-GMPS »
Uniprot-GMPS »
Biogrid-GMPS »
ProteomicsDB-GMPS »

Tumorportal-GMPS »
COSMIC-GMPS »
GenomeRNAi-GMPS »
Genecards-GMPS


Protein-protein Interactions for GMPS
Show screen data for Category Name and Description Link to cat description Data Source
Category members IP bait EIF2C2 Cat. description Hein, Mann, Cell 2015
Category members IP bait KIF7 Cat. description Hein, Mann, Cell 2015
Category members IP bait NEDD1 Cat. description Hein, Mann, Cell 2015
Category members IP bait PAX6 Cat. description Hein, Mann, Cell 2015
Category members IP bait PKM Cat. description Hein, Mann, Cell 2015
Category members IP bait RACGAP1 Cat. description Hein, Mann, Cell 2015
Category members IP bait USP7 Cat. description Hein, Mann, Cell 2015
Category members IP bait WDR48 Cat. description Hein, Mann, Cell 2015
Category members IP bait GTF2E2 Cat. description BioPlex, Huttlin, Gygi, Cell 2015


Protein Domains in GMPS
Domain name Domain Description TC-NER relevance -log10(p-value)
Category members GATASE IPR017926 0.04
Category members Peptidase_C26 IPR011697 0.04
Category members Asn_synthase IPR001962 0
Category members tRNA-specific_2-thiouridylase IPR004506 0
Category members QueC IPR018317 0
Category members NAD/GMP_synthase IPR022310 0
Category members Class_I_gatase-like IPR029062 0


Protein complexes (CORUM database) featuring GMPS
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)


Categories featuring GMPS
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)
Category members GO Category GO:0005829 cytosol Database INF
Category members GO Category GO:0005737 cytoplasm Database 12.81
Category members GO Category GO:0005524 ATP binding Database 5.54
Category members Human mutations Sanger_cancer_genes Sanger cancer genes Database 4.88
Category members GO Category GO:0006541 glutamine metabolic process Database 0.47
Category members GO Category GO:0008033 tRNA processing Database 0.39
Category members GO Category GO:0044281 small molecule metabolic process Database 0.35
Category members GO Category GO:0006177 GMP biosynthetic process Database 0.29
Category members Pathway Pathway_273 REACTOME_PURINE_RIBONUCLEOSIDE_MONOPHOSPHATE_BIOSYNTHESIS 0 0.23
Category members Pathway Pathway_68 KEGG_PURINE_METABOLISM 0 0.23
Category members GO Category GO:0016787 hydrolase activity Database 0.22
Category members Pathway Pathway_204 REACTOME_PURINE_METABOLISM 0 0.22
Category members GO Category GO:0009168 purine ribonucleoside monophosphate biosynthetic process Database 0.12
Category members GO Category GO:0006144 purine nucleobase metabolic process Database 0.11
Category members GO Category GO:0016740 transferase activity Database 0.07
Category members Pathway Pathway_206 REACTOME_METABOLISM_OF_NUCLEOTIDES 0 0
Category members Pathway Pathway_77 KEGG_DRUG_METABOLISM_OTHER_ENZYMES 0 0
Category members GO Category GO:0004066 asparagine synthase (glutamine-hydrolyzing) activity Database 0
Category members GO Category GO:0006164 purine nucleotide biosynthetic process Database 0
Category members GO Category GO:0006529 asparagine biosynthetic process Database 0
Category members GO Category GO:0009113 purine nucleobase biosynthetic process Database 0
Category members GO Category GO:0016462 pyrophosphatase activity Database 0
Category members GO Category GO:0055086 nucleobase-containing small molecule metabolic process Database 0


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