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Query: GBA

RNAi screen result RNAPII IP (PI) CSB IP CSB IP (PI) Chrom. Chrom. (PI) Phosphorylation Ubiquitylation
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[Click on the plots to view the data selection in the respective scatterplot]

Protein Results:

 Results for post-translational modifications: see below | Red/green: hit at lower/upper end of the respective screen
Gene name Point score Z-score sums RNAi high RNAi low RNAPII-IP (PI) CSB-IP CSB-IP (PI) Chrom. Chrom. (PI)
GBA 1 3.494 -1.380 2.580 0.407 0.357 0.150

PTM Sites:

 Back to Protein Results | Red/green: hit at lower/upper end of the respective screen
Gene name PTM type PTM site UV UV (PI) Sequence

Background Information for GBA:


Pubmed-GBA »
Uniprot-GBA »
Biogrid-GBA »
ProteomicsDB-GBA »

Tumorportal-GBA »
COSMIC-GBA »
GenomeRNAi-GBA »
Genecards-GBA


Protein-protein Interactions for GBA
Show screen data for Category Name and Description Link to cat description Data Source
Category members IP bait GBA Cat. description Hein, Mann, Cell 2015
Category members IP bait RAB27B Cat. description BioPlex, Huttlin, Gygi, Cell 2015


Protein Domains in GBA
Domain name Domain Description TC-NER relevance -log10(p-value)
Category members Glycoside_hydrolase_SF IPR017853 0


Protein complexes (CORUM database) featuring GBA
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)


Categories featuring GBA
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)
Category members GO Category GO:0005765 lysosomal membrane Database 0.82
Category members GO Category GO:0043627 response to estrogen Database 0.4
Category members GO Category GO:0044281 small molecule metabolic process Database 0.35
Category members Disease phenotype Gaucher_disease_type_1 Gaucher disease type 1 Database 0.21
Category members GO Category GO:0008219 cell death Database 0.08
Category members GO Category GO:0005975 carbohydrate metabolic process Database 0.07
Category members GO Category GO:0043202 lysosomal lumen Database 0.07
Category members GO Category GO:0051384 response to glucocorticoid Database 0.04
Category members GO Category GO:0071356 cellular response to tumor necrosis factor Database 0.03
Category members GO Category GO:0023021 termination of signal transduction Database 0.03
Category members GO Category GO:0032715 negative regulation of interleukin-6 production Database 0.03
Category members GO Category GO:0009268 response to pH Database 0.01
Category members Pathway Pathway_100 REACTOME_PHOSPHOLIPID_METABOLISM 0 0
Category members Pathway Pathway_126 REACTOME_GLYCOSPHINGOLIPID_METABOLISM 0 0
Category members Pathway Pathway_127 KEGG_SPHINGOLIPID_METABOLISM 0 0
Category members Pathway Pathway_128 REACTOME_SPHINGOLIPID_METABOLISM 0 0
Category members Pathway Pathway_129 KEGG_OTHER_GLYCAN_DEGRADATION 0 0
Category members Pathway Pathway_4 REACTOME_METABOLISM_OF_LIPIDS_AND_LIPOPROTEINS 0 0
Category members Pathway Pathway_74 KEGG_LYSOSOME 0 0
Category members Disease phenotype PARKINSON_DISEASE_LATE-ONSET PARKINSON DISEASE LATE-ONSET Database 0
Category members Disease phenotype Young_adult-onset_Parkinsonism Young adult-onset Parkinsonism Database 0
Category members GO Category GO:0004348 glucosylceramidase activity Database 0
Category members GO Category GO:0005102 receptor binding Database 0
Category members GO Category GO:0006665 sphingolipid metabolic process Database 0
Category members GO Category GO:0006680 glucosylceramide catabolic process Database 0
Category members GO Category GO:0006687 glycosphingolipid metabolic process Database 0
Category members GO Category GO:0033561 regulation of water loss via skin Database 0
Category members GO Category GO:0033574 response to testosterone Database 0
Category members GO Category GO:0035307 positive regulation of protein dephosphorylation Database 0
Category members GO Category GO:0043407 negative regulation of MAP kinase activity Database 0
Category members GO Category GO:0043589 skin morphogenesis Database 0
Category members GO Category GO:0046512 sphingosine biosynthetic process Database 0
Category members GO Category GO:0046513 ceramide biosynthetic process Database 0
Category members GO Category GO:0050728 negative regulation of inflammatory response Database 0


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