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Query: FOXP1

This is a cancer-associated gene according to the Sanger cancer gene census.

RNAi screen result RNAPII IP (PI) CSB IP CSB IP (PI) Chrom. Chrom. (PI) Phosphorylation Ubiquitylation
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[Click on the plots to view the data selection in the respective scatterplot]

Protein Results:

 Results for post-translational modifications: see below | Red/green: hit at lower/upper end of the respective screen
Gene name Point score Z-score sums RNAi high RNAi low RNAPII-IP (PI) CSB-IP CSB-IP (PI) Chrom. Chrom. (PI)
FOXP1 0 3.891 -1.070 2.200

PTM Sites:

 Back to Protein Results | Red/green: hit at lower/upper end of the respective screen
Gene name PTM type PTM site UV UV (PI) Sequence
FOXP1 Phosphorylation S442 1.013 0.678 _RYS(ph)DKYNVPISSADIAQNQEFYK_

Background Information for FOXP1:


Pubmed-FOXP1 »
Uniprot-FOXP1 »
Biogrid-FOXP1 »
ProteomicsDB-FOXP1 »

Tumorportal-FOXP1 »
COSMIC-FOXP1 »
GenomeRNAi-FOXP1 »
Genecards-FOXP1


Protein-protein Interactions for FOXP1
Show screen data for Category Name and Description Link to cat description Data Source
Category members IP bait FOXP2 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait FOXP3 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait KIAA1984 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait SNRNP70 Cat. description BioPlex, Huttlin, Gygi, Cell 2015


Protein Domains in FOXP1
Domain name Domain Description TC-NER relevance -log10(p-value)
Category members TF_fork_head IPR001766 0


Protein complexes (CORUM database) featuring FOXP1
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)


Categories featuring FOXP1
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)
Category members GO Category GO:0005515 protein binding Database INF
Category members GO Category GO:0005634 nucleus Database INF
Category members GO Category GO:0005737 cytoplasm Database 12.81
Category members GO Category GO:0003682 chromatin binding Database 6.07
Category members Human mutations Sanger_cancer_genes Sanger cancer genes Database 4.88
Category members GO Category GO:0003677 DNA binding Database 1.53
Category members GO Category GO:0045892 negative regulation of transcription, DNA-dependent Database 1.15
Category members GO Category GO:0006351 transcription, DNA-templated Database 1.07
Category members GO Category GO:0003700 sequence-specific DNA binding transcription factor activity Database 0.63
Category members GO Category GO:0050679 positive regulation of epithelial cell proliferation Database 0.5
Category members GO Category GO:0033152 immunoglobulin V(D)J recombination Database 0.46
Category members GO Category GO:0030324 lung development Database 0.39
Category members GO Category GO:0045893 positive regulation of transcription, DNA-dependent Database 0.28
Category members GO Category GO:0046982 protein heterodimerization activity Database 0.28
Category members Disease phenotype Precursor_B-cell_acute_lymphoblastic_leukemia Precursor B-cell acute lymphoblastic leukemia Database 0.25
Category members GO Category GO:0001701 in utero embryonic development Database 0.2
Category members GO Category GO:0007389 pattern specification process Database 0.18
Category members GO Category GO:0043565 sequence-specific DNA binding Database 0.18
Category members GO Category GO:0045944 positive regulation of transcription from RNA polymerase II promoter Database 0.13
Category members GO Category GO:0021517 ventral spinal cord development Database 0.03
Category members Disease phenotype MALT_lymphoma MALT lymphoma Database 0
Category members GO Category GO:0002053 positive regulation of mesenchymal cell proliferation Database 0
Category members GO Category GO:0002329 pre-B cell differentiation Database 0
Category members GO Category GO:0002639 positive regulation of immunoglobulin production Database 0
Category members GO Category GO:0003705 RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity Database 0
Category members GO Category GO:0006355 regulation of transcription, DNA-dependent Database 0
Category members GO Category GO:0007507 heart development Database 0
Category members GO Category GO:0007519 skeletal muscle tissue development Database 0
Category members GO Category GO:0008045 motor neuron axon guidance Database 0
Category members GO Category GO:0008301 DNA binding, bending Database 0
Category members GO Category GO:0009790 embryo development Database 0
Category members GO Category GO:0042803 protein homodimerization activity Database 0
Category members GO Category GO:0045214 sarcomere organization Database 0
Category members GO Category GO:0046872 metal ion binding Database 0
Category members GO Category GO:0048745 smooth muscle tissue development Database 0
Category members GO Category GO:0055007 cardiac muscle cell differentiation Database 0
Category members GO Category GO:0060043 regulation of cardiac muscle cell proliferation Database 0
Category members GO Category GO:0061140 lung secretory cell differentiation Database 0


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