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Query: FASN

RNAi screen result RNAPII IP (PI) CSB IP CSB IP (PI) Chrom. Chrom. (PI) Phosphorylation Ubiquitylation
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[Click on the plots to view the data selection in the respective scatterplot]

Protein Results:

 Results for post-translational modifications: see below | Red/green: hit at lower/upper end of the respective screen
Gene name Point score Z-score sums RNAi high RNAi low RNAPII-IP (PI) CSB-IP CSB-IP (PI) Chrom. Chrom. (PI)
FASN 0 -0.612 -0.350 -0.530 -0.550 -0.478 -0.892 -0.134 0.004

PTM Sites:

 Back to Protein Results | Red/green: hit at lower/upper end of the respective screen
Gene name PTM type PTM site UV UV (PI) Sequence
FASN Phosphorylation S207 0.105 0.507 _LGMLS(ph)PEGTCK_
FASN Ubiquitylation K2449 -0.636 0.411 _AK(gl)TGGAYGEDLGADYNLSQVCDGK_
FASN Ubiquitylation K2426 -0.591 0.390 _SFYYK(gl)LR_
FASN Ubiquitylation K326 0.372 _QEPLLIGSTK(gl)SNM(ox)GHPEPASGLAALAK_
FASN Ubiquitylation K673 0.201 0.234 _K(gl)EGVFAK(gl)EVR_
FASN Ubiquitylation K1142 0.056 0.226 _AALQEELQLCK(gl)GLVQALQTK_
FASN Ubiquitylation K1072 0.386 0.144 _LYTLQDK(gl)AQVADVVVSR_
FASN Ubiquitylation K235 -0.149 0.117 _SEGVVAVLLTK(gl)K_
FASN Ubiquitylation K1911 -0.329 0.084 _GVQK(gl)LVLTSR_
FASN Ubiquitylation K213 -0.346 -0.011 _LGMLSPEGTCK(gl)AFDTAGNGYCR_
FASN Ubiquitylation K236 -0.149 -0.024 _SEGVVAVLLTKK(gl)_
FASN Ubiquitylation K1151 0.234 -0.094 _GLVQALQTK(gl)VTQQGLK_
FASN Phosphorylation T2204 -0.587 -0.205 _ADEASELACPT(ph)PKEDGLAQQQTQLNLR_
FASN Ubiquitylation K1704 -0.247 _VFTTVGSAEK(gl)R_
FASN Ubiquitylation K436 -0.250 _TPEAVQK(gl)LLEQGLR_
FASN Ubiquitylation K2391 -0.844 -0.267 _VLEALLPLK(gl)GLEER_
FASN Ubiquitylation K1239 -0.362 _ACLDTAVENMPSLK(gl)MK_
FASN Ubiquitylation K2438 -0.623 -0.362 _AK(gl)YHGNVM(ox)LLR_
FASN Phosphorylation S1028 0.133 -0.404 _DNWVS(ph)FM(ox)DTMLQMSILGSAK_
FASN Ubiquitylation K1158 -0.496 -0.468 _VTQQGLK(gl)MVVPGLDGAQIPRDPSQQELPR_
FASN Ubiquitylation K1927 -0.254 -0.492 _TGYQAK(gl)QVR_
FASN Ubiquitylation K41 -0.859 -0.543 _WK(gl)AGLYGLPR_
FASN Ubiquitylation K1241 -0.510 -0.579 _ACLDTAVENMPSLKMK(gl)_
FASN Ubiquitylation K528 -0.086 -0.587 _SDEAVK(gl)PFGLK_
FASN Ubiquitylation K1878 0.194 -0.638 _LM(ox)SAISK(gl)TFCPAHK_
FASN Phosphorylation S1411 -0.978 _RPTPQDS(ph)PIFLPVDDTSFR_
FASN Phosphorylation S974 -1.491 -0.989 _LFDHPES(ph)PTPNPTEPLFLAQAEVYK_
FASN Ubiquitylation K776 -1.050 _GLK(gl)PSCTIIPLMK_
FASN Ubiquitylation K1866 -1.615 -1.050 _VVVQVLAEEPEAVLK(gl)GAKPK_
FASN Phosphorylation S2198 -1.105 -1.296 _ADEAS(ph)ELACPT(ph)PK_
FASN Ubiquitylation K1065 -1.459 _QK(gl)LYTLQDK_
FASN Phosphorylation T976 -1.624 -1.495 _LFDHPESPT(ph)PNPTEPLFLAQAEVYK_
FASN Ubiquitylation K1582 -1.228 -2.032 _DIMLATGK(gl)LSPDAIPGK_
FASN Ubiquitylation K1847 0.204 _YMAQGK(gl)HIGK_
FASN Ubiquitylation K1869 -0.967 _VVVQVLAEEPEAVLKGAK(gl)_
FASN Ubiquitylation K1871 -0.926 _GAK(gl)PKLM(ox)SAISK_
FASN Ubiquitylation K1993 -1.641 _DGLLENQTPEFFQDVCK(gl)PK_

Background Information for FASN:


Pubmed-FASN »
Uniprot-FASN »
Biogrid-FASN »
ProteomicsDB-FASN »

Tumorportal-FASN »
COSMIC-FASN »
GenomeRNAi-FASN »
Genecards-FASN


Protein-protein Interactions for FASN
Show screen data for Category Name and Description Link to cat description Data Source
Category members IP bait BAG2 Cat. description Hein, Mann, Cell 2015
Category members IP bait DNAJC7 Cat. description Hein, Mann, Cell 2015
Category members IP bait HSPA5 Cat. description Hein, Mann, Cell 2015
Category members IP bait KIF11 Cat. description Hein, Mann, Cell 2015
Category members IP bait TUBG1 Cat. description Hein, Mann, Cell 2015
Category members IP bait FASN Cat. description BioPlex, Huttlin, Gygi, Cell 2015


Protein Domains in FASN
Domain name Domain Description TC-NER relevance -log10(p-value)
Category members Acyl_transferase IPR014043 0.26
Category members Malonyl_transacylase_ACP-bd IPR016036 0.26
Category members PKS_acyl_transferase IPR020801 0.26
Category members Thiolase-like IPR016039 0.26
Category members PKS_ER IPR020843 0.22
Category members Methyltransf_11 IPR013216 0.2
Category members GroES-like IPR011032 0.09
Category members Thioesterase IPR001031 0.04
Category members SAM-dependent_MTases-like IPR029063 0.04
Category members ADH_C IPR013149 0.02
Category members DH_sc/Rdtase_SDR IPR002198 0
Category members Acyl_carrier_prot-like IPR009081 0
Category members Methyltransf_12 IPR013217 0
Category members PKS_KR IPR013968 0
Category members Ketoacyl_synth_N IPR014030 0
Category members Acyl_Trfase/lysoPLipase IPR016035 0
Category members PKS/FAS_KR IPR020842 0
Category members AB_hydrolase IPR029058 0


Protein complexes (CORUM database) featuring FASN
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)


Categories featuring FASN
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)
Category members GO Category GO:0005515 protein binding Database INF
Category members GO Category GO:0005829 cytosol Database INF
Category members GO Category GO:0005737 cytoplasm Database 12.81
Category members GO Category GO:0042470 melanosome Database 5.59
Category members GO Category GO:0005739 mitochondrion Database 1.67
Category members GO Category GO:0005886 plasma membrane Database 1.21
Category members Pathway Pathway_5 REACTOME_INTEGRATION_OF_ENERGY_METABOLISM 0 0.9
Category members Pathway Pathway_123 BIOCARTA_CHREBP2_PATHWAY 0 0.61
Category members GO Category GO:0042587 glycogen granule Database 0.44
Category members GO Category GO:0044281 small molecule metabolic process Database 0.35
Category members GO Category GO:0016747 transferase activity, transferring acyl groups other than amino-acyl groups Database 0.33
Category members GO Category GO:0008270 zinc ion binding Database 0.29
Category members GO Category GO:0005794 Golgi apparatus Database 0.27
Category members GO Category GO:0006767 water-soluble vitamin metabolic process Database 0.27
Category members GO Category GO:0004314 [acyl-carrier-protein] S-malonyltransferase activity Database 0.26
Category members GO Category GO:0042802 identical protein binding Database 0.26
Category members Pathway Pathway_1 REACTOME_FATTY_ACID_TRIACYLGLYCEROL_AND_KETONE_BODY_METABOLISM 0 0.23
Category members GO Category GO:0006766 vitamin metabolic process Database 0.23
Category members GO Category GO:0006112 energy reserve metabolic process Database 0.21
Category members Pathway Pathway_44 KEGG_INSULIN_SIGNALING_PATHWAY 0 0.21
Category members Pathway Pathway_6 REACTOME_FATTY_ACYL_COA_BIOSYNTHESIS 0 0.2
Category members GO Category GO:0071353 cellular response to interleukin-4 Database 0.19
Category members Pathway Pathway_279 REACTOME_METABOLISM_OF_VITAMINS_AND_COFACTORS 0 0.18
Category members Pathway Pathway_200 PID_P73PATHWAY 0 0.11
Category members GO Category GO:0003824 catalytic activity Database 0.11
Category members GO Category GO:0009058 biosynthetic process Database 0.11
Category members GO Category GO:0035338 long-chain fatty-acyl-CoA biosynthetic process Database 0.1
Category members Pathway Pathway_2 REACTOME_TRIGLYCERIDE_BIOSYNTHESIS 0 0.08
Category members GO Category GO:0031325 positive regulation of cellular metabolic process Database 0.04
Category members GO Category GO:0015939 pantothenate metabolic process Database 0.03
Category members Pathway Pathway_209 PID_DELTA_NP63_PATHWAY 0 0
Category members Pathway Pathway_4 REACTOME_METABOLISM_OF_LIPIDS_AND_LIPOPROTEINS 0 0
Category members Pathway Pathway_412 REACTOME_VITAMIN_B5_PANTOTHENATE_METABOLISM 0 0
Category members Disease phenotype Autosomal_Recessive_Mental_Retardation Autosomal Recessive Mental Retardation Database 0
Category members GO Category GO:0004315 3-oxoacyl-[acyl-carrier-protein] synthase activity Database 0
Category members GO Category GO:0004320 oleoyl-[acyl-carrier-protein] hydrolase activity Database 0
Category members GO Category GO:0006084 acetyl-CoA metabolic process Database 0
Category members GO Category GO:0006631 fatty acid metabolic process Database 0
Category members GO Category GO:0006633 fatty acid biosynthetic process Database 0
Category members GO Category GO:0008144 drug binding Database 0
Category members GO Category GO:0008152 metabolic process Database 0
Category members GO Category GO:0008168 methyltransferase activity Database 0
Category members GO Category GO:0016295 myristoyl-[acyl-carrier-protein] hydrolase activity Database 0
Category members GO Category GO:0016296 palmitoyl-[acyl-carrier-protein] hydrolase activity Database 0
Category members GO Category GO:0016491 oxidoreductase activity Database 0
Category members GO Category GO:0016788 hydrolase activity, acting on ester bonds Database 0
Category members GO Category GO:0019432 triglyceride biosynthetic process Database 0
Category members GO Category GO:0042803 protein homodimerization activity Database 0
Category members GO Category GO:0044255 cellular lipid metabolic process Database 0
Category members GO Category GO:0055114 oxidation-reduction process Database 0
Category members GO Category GO:0070402 NADPH binding Database 0


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