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Query: FAF1

RNAi screen result RNAPII IP (PI) CSB IP CSB IP (PI) Chrom. Chrom. (PI) Phosphorylation Ubiquitylation
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[Click on the plots to view the data selection in the respective scatterplot]

Protein Results:

 Results for post-translational modifications: see below | Red/green: hit at lower/upper end of the respective screen
Gene name Point score Z-score sums RNAi high RNAi low RNAPII-IP (PI) CSB-IP CSB-IP (PI) Chrom. Chrom. (PI)
FAF1 0 1.952 0.870 -0.650 0.213

PTM Sites:

 Back to Protein Results | Red/green: hit at lower/upper end of the respective screen
Gene name PTM type PTM site UV UV (PI) Sequence
FAF1 Ubiquitylation K146 0.008 0.988 _GWK(gl)TGDVEDSTVLK_
FAF1 Ubiquitylation K221 0.454 0.951 _EYNLNFSGSSTIQEVK(gl)R_
FAF1 Ubiquitylation K143 -0.325 0.510 _MLLK(gl)GWK_
FAF1 Phosphorylation S582 0.205 0.092 _TPS(ph)GEFLER_
FAF1 Ubiquitylation K157 -0.570 -0.411 _TGDVEDSTVLK(gl)SLHLPK_
FAF1 Ubiquitylation K139 -0.732 _QILENELQIPVSK(gl)MLLK_
FAF1 Phosphorylation T580 -0.344 _IRT(ph)PSGEFLER_

Background Information for FAF1:


Pubmed-FAF1 »
Uniprot-FAF1 »
Biogrid-FAF1 »
ProteomicsDB-FAF1 »

Tumorportal-FAF1 »
COSMIC-FAF1 »
GenomeRNAi-FAF1 »
Genecards-FAF1


Protein-protein Interactions for FAF1
Show screen data for Category Name and Description Link to cat description Data Source
Category members IP bait BHLHA15 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait CHCHD10 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait CLEC3A Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait MAGIX Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait PRCC Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait TCEAL1 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait YTHDF1 Cat. description BioPlex, Huttlin, Gygi, Cell 2015


Protein Domains in FAF1
Domain name Domain Description TC-NER relevance -log10(p-value)
Category members Ubiquitin-rel_dom IPR029071 1.79
Category members UAS IPR006577 0.57
Category members UBA-like IPR009060 0.17
Category members UBX_dom IPR001012 0.08


Protein complexes (CORUM database) featuring FAF1
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)


Categories featuring FAF1
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)
Category members GO Category GO:0005515 protein binding Database INF
Category members GO Category GO:0005634 nucleus Database INF
Category members GO Category GO:0005829 cytosol Database INF
Category members GO Category GO:0005737 cytoplasm Database 12.81
Category members GO Category GO:0005635 nuclear envelope Database 7.22
Category members DDR Literature pubmedid:19647519 Paulsen et al., 2009 siRNA screen for g-H2A.x phosphorylation 3.6
Category members GO Category GO:0031625 ubiquitin protein ligase binding Database 2.54
Category members GO Category GO:0006915 apoptotic process Database 2.12
Category members GO Category GO:0019904 protein domain specific binding Database 1.85
Category members Pathway Pathway_962 BIOCARTA_FAS_PATHWAY 0 1.75
Category members GO Category GO:0031072 heat shock protein binding Database 1.59
Category members GO Category GO:0043130 ubiquitin binding Database 1.22
Category members GO Category GO:0042176 regulation of protein catabolic process Database 0.91
Category members GO Category GO:0031334 positive regulation of protein complex assembly Database 0.69
Category members GO Category GO:0048471 perinuclear region of cytoplasm Database 0.39
Category members GO Category GO:0019901 protein kinase binding Database 0.37
Category members GO Category GO:0043065 positive regulation of apoptotic process Database 0.26
Category members GO Category GO:0051059 NF-kappaB binding Database 0.25
Category members GO Category GO:0034098 Cdc48p-Npl4p-Ufd1p AAA ATPase complex Database 0.25
Category members GO Category GO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process Database 0.23
Category members GO Category GO:0008219 cell death Database 0.08
Category members Pathway Pathway_386 ST_FAS_SIGNALING_PATHWAY 0 0.02
Category members GO Category GO:0045859 regulation of protein kinase activity Database 0.01
Category members GO Category GO:0007253 cytoplasmic sequestering of NF-kappaB Database 0
Category members GO Category GO:0019887 protein kinase regulator activity Database 0
Category members GO Category GO:0030155 regulation of cell adhesion Database 0
Category members GO Category GO:0031265 CD95 death-inducing signaling complex Database 0


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