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Query: EIF4G2

RNAi screen result RNAPII IP (PI) CSB IP CSB IP (PI) Chrom. Chrom. (PI) Phosphorylation Ubiquitylation
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[Click on the plots to view the data selection in the respective scatterplot]

Protein Results:

 Results for post-translational modifications: see below | Red/green: hit at lower/upper end of the respective screen
Gene name Point score Z-score sums RNAi high RNAi low RNAPII-IP (PI) CSB-IP CSB-IP (PI) Chrom. Chrom. (PI)
EIF4G2 0 -0.875 0.700 0.050 -0.629 -0.963
EIF4G2 0 -0.875 0.700 0.050 1.131 -0.729 0.052

PTM Sites:

 Back to Protein Results | Red/green: hit at lower/upper end of the respective screen
Gene name PTM type PTM site UV UV (PI) Sequence
EIF4G2 Ubiquitylation K361 0.871 0.407 _MCSLMLSK(gl)ELPAR_
EIF4G2 Phosphorylation S468 -0.235 -0.781 _FS(ph)PTMGR_
EIF4G2 Phosphorylation T581 -1.576 -0.919 _TQT(ph)PPLGQTPQLGLK_
EIF4G2 Ubiquitylation K260 0.068 -1.066 _NVDVYDK(gl)R_
EIF4G2 Phosphorylation T458 -0.619 -1.448 _DPLGGLADMFGQMPGSGIGT(ph)GPGVIQDRFSPTM(ox)GR_
EIF4G2 Phosphorylation S454 -1.517 _MDRDPLGGLADMFGQMPGS(ph)GIGTGPGVIQDRFSPTMGR_

Background Information for EIF4G2:


Pubmed-EIF4G2 »
Uniprot-EIF4G2 »
Biogrid-EIF4G2 »
ProteomicsDB-EIF4G2 »

Tumorportal-EIF4G2 »
COSMIC-EIF4G2 »
GenomeRNAi-EIF4G2 »
Genecards-EIF4G2


Protein-protein Interactions for EIF4G2
Show screen data for Category Name and Description Link to cat description Data Source
Category members IP bait EIF3A Cat. description Hein, Mann, Cell 2015
Category members IP bait EIF3E Cat. description Hein, Mann, Cell 2015
Category members IP bait EIF3I Cat. description Hein, Mann, Cell 2015
Category members IP bait HSPA5 Cat. description Hein, Mann, Cell 2015
Category members IP bait NPM1 Cat. description Hein, Mann, Cell 2015
Category members IP bait CYP1A1 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait EIF4A1 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait MAGEA1 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait QPRT Cat. description BioPlex, Huttlin, Gygi, Cell 2015


Protein Domains in EIF4G2
Domain name Domain Description TC-NER relevance -log10(p-value)
Category members ARM-type_fold IPR016024 9.26
Category members W2_domain IPR003307 0.04
Category members MIF4G-like_typ-3 IPR003890 0
Category members Initiation_fac_eIF4g_MI IPR003891 0


Protein complexes (CORUM database) featuring EIF4G2
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)


Categories featuring EIF4G2
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)
Category members GO Category GO:0003723 RNA binding Database INF
Category members GO Category GO:0005515 protein binding Database INF
Category members GO Category GO:0005829 cytosol Database INF
Category members GO Category GO:0005737 cytoplasm Database 12.81
Category members GO Category GO:0005488 binding Database 9.32
Category members Pathway Pathway_689 REACTOME_ANTIVIRAL_MECHANISM_BY_IFN_STIMULATED_GENES 0 3.51
Category members Pathway Pathway_458 REACTOME_IMMUNE_SYSTEM 0 3
Category members Pathway Pathway_699 REACTOME_INTERFERON_SIGNALING 0 0.86
Category members Pathway Pathway_1274 BIOCARTA_EIF_PATHWAY 0 0.78
Category members GO Category GO:0003743 translation initiation factor activity Database 0.71
Category members GO Category GO:0008135 translation factor activity, nucleic acid binding Database 0.53
Category members GO Category GO:0019221 cytokine-mediated signaling pathway Database 0.44
Category members Pathway Pathway_505 REACTOME_CYTOKINE_SIGNALING_IN_IMMUNE_SYSTEM 0 0.33
Category members GO Category GO:0008219 cell death Database 0.08
Category members GO Category GO:0016281 eukaryotic translation initiation factor 4F complex Database 0.08
Category members GO Category GO:0006446 regulation of translational initiation Database 0.04
Category members Pathway Pathway_1014 KEGG_VIRAL_MYOCARDITIS 0 0
Category members Pathway Pathway_552 BIOCARTA_MTOR_PATHWAY 0 0
Category members Pathway Pathway_638 BIOCARTA_EIF4_PATHWAY 0 0
Category members GO Category GO:0007050 cell cycle arrest Database 0


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