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Query: EEA1

RNAi screen result RNAPII IP (PI) CSB IP CSB IP (PI) Chrom. Chrom. (PI) Phosphorylation Ubiquitylation
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[Click on the plots to view the data selection in the respective scatterplot]

Protein Results:

 Results for post-translational modifications: see below | Red/green: hit at lower/upper end of the respective screen
Gene name Point score Z-score sums RNAi high RNAi low RNAPII-IP (PI) CSB-IP CSB-IP (PI) Chrom. Chrom. (PI)
EEA1 1 5.597 1.570 -0.620 1.098 0.020 0.177

PTM Sites:

 Back to Protein Results | Red/green: hit at lower/upper end of the respective screen
Gene name PTM type PTM site UV UV (PI) Sequence
EEA1 Ubiquitylation K1029 1.686 _SQETFK(gl)QLQSDFYGR_
EEA1 Phosphorylation S354 1.047 1.214 _LS(ph)ASETSLHR_
EEA1 Ubiquitylation K100 0.234 1.002 _QEVQDLQASLK(gl)EEK_
EEA1 Ubiquitylation K103 -0.344 _QEVQDLQASLKEEK(gl)_
EEA1 Ubiquitylation K1162 0.355 _EITNLK(gl)DAK_
EEA1 Ubiquitylation K1178 -1.915 _LELQGK(gl)ADSLK_
EEA1 Ubiquitylation K1225 -1.291 _LHSEIKEK(gl)_
EEA1 Ubiquitylation K1312 -0.851 _LQTK(gl)VLELQR_

Background Information for EEA1:


Pubmed-EEA1 »
Uniprot-EEA1 »
Biogrid-EEA1 »
ProteomicsDB-EEA1 »

Tumorportal-EEA1 »
COSMIC-EEA1 »
GenomeRNAi-EEA1 »
Genecards-EEA1


Protein-protein Interactions for EEA1
Show screen data for Category Name and Description Link to cat description Data Source
Category members IP bait DCTN2 Cat. description Hein, Mann, Cell 2015
Category members IP bait EEA1 Cat. description Hein, Mann, Cell 2015
Category members IP bait MARK2 Cat. description Hein, Mann, Cell 2015
Category members IP bait PCNA Cat. description Hein, Mann, Cell 2015
Category members IP bait RACGAP1 Cat. description Hein, Mann, Cell 2015
Category members IP bait TNKS2 Cat. description Hein, Mann, Cell 2015
Category members IP bait TPI1 Cat. description Hein, Mann, Cell 2015
Category members IP bait TRIP11 Cat. description Hein, Mann, Cell 2015
Category members IP bait BMP1 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait C10orf125 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait C4orf43 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait FCGR2A Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait MLLT6 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait NUPL1 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait SERPINB2 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait SNRNP27 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait USP47 Cat. description BioPlex, Huttlin, Gygi, Cell 2015


Protein Domains in EEA1
Domain name Domain Description TC-NER relevance -log10(p-value)
Category members Znf_FYVE_PHD IPR011011 1.23
Category members Znf_C2H2 IPR007087 0.92
Category members Znf_FYVE IPR000306 0
Category members Znf_FYVE-rel IPR017455 0


Protein complexes (CORUM database) featuring EEA1
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)
Category members Corum 2572 RAB5-EEA1 complex Database 0
Category members Corum 2573 Class C VPS/HOPS complex Database 0


Categories featuring EEA1
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)
Category members GO Category GO:0005515 protein binding Database INF
Category members GO Category GO:0005829 cytosol Database INF
Category members GO Category GO:0005737 cytoplasm Database 12.81
Category members Pathway Pathway_458 REACTOME_IMMUNE_SYSTEM 0 3
Category members GO Category GO:0006906 vesicle fusion Database 1.28
Category members GO Category GO:0005769 early endosome Database 1.26
Category members Pathway Pathway_666 KEGG_ENDOCYTOSIS 0 1.25
Category members GO Category GO:0005886 plasma membrane Database 1.21
Category members Pathway Pathway_63 BIOCARTA_PTDINS_PATHWAY 0 0.91
Category members GO Category GO:0005516 calmodulin binding Database 0.74
Category members GO Category GO:0031901 early endosome membrane Database 0.58
Category members GO Category GO:0016020 membrane Database 0.52
Category members GO Category GO:0006897 endocytosis Database 0.31
Category members Pathway Pathway_460 REACTOME_INNATE_IMMUNE_SYSTEM 0 0.29
Category members GO Category GO:0005768 endosome Database 0.29
Category members GO Category GO:0008270 zinc ion binding Database 0.29
Category members GO Category GO:0055037 recycling endosome Database 0.29
Category members Pathway Pathway_527 REACTOME_TOLL_RECEPTOR_CASCADES 0 0.17
Category members GO Category GO:0019897 extrinsic to plasma membrane Database 0.03
Category members GO Category GO:0005545 1-phosphatidylinositol binding Database 0
Category members GO Category GO:0030742 GTP-dependent protein binding Database 0
Category members GO Category GO:0031410 cytoplasmic vesicle Database 0
Category members GO Category GO:0042803 protein homodimerization activity Database 0
Category members GO Category GO:0045022 early endosome to late endosome transport Database 0
Category members GO Category GO:0046872 metal ion binding Database 0


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