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Query: DSP

RNAi screen result RNAPII IP (PI) CSB IP CSB IP (PI) Chrom. Chrom. (PI) Phosphorylation Ubiquitylation
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[Click on the plots to view the data selection in the respective scatterplot]

Protein Results:

 Results for post-translational modifications: see below | Red/green: hit at lower/upper end of the respective screen
Gene name Point score Z-score sums RNAi high RNAi low RNAPII-IP (PI) CSB-IP CSB-IP (PI) Chrom. Chrom. (PI)
DSP 0 1.319 -0.660 1.420 -2.938 -0.696 -0.240

PTM Sites:

 Back to Protein Results | Red/green: hit at lower/upper end of the respective screen
Gene name PTM type PTM site UV UV (PI) Sequence
DSP Ubiquitylation K1028 1.475 _SLEDLK(gl)LK_
DSP Ubiquitylation K1802 0.287 1.314 _IQESK(gl)NQCTQVVQER_
DSP Ubiquitylation K322 1.259 _MSQLEVK(gl)EK_
DSP Ubiquitylation K324 1.259 _MSQLEVK(gl)EK_
DSP Phosphorylation S2632 1.154 _SSSFSDTLEESS(ph)PIAAIFDTENLEKIS(ph)ITEGIERGIVDSITGQR_
DSP Phosphorylation S2209 0.704 1.055 _SMS(ph)FQGIR_
DSP Phosphorylation S176 0.188 _GGGGYTCQS(ph)GSGWDEFTK_
DSP Phosphorylation S2608 0.063 0.167 _SSS(ph)FSDTLEESSPIAAIFDTENLEK_
DSP Ubiquitylation K140 0.440 0.037 _QMGQPCDAYQK(gl)R_
DSP Phosphorylation S2606 -0.052 -0.018 _S(ph)SSFSDTLEESSPIAAIFDTENLEK_
DSP Phosphorylation S22 0.083 -0.070 _AES(ph)GPDLR_
DSP Ubiquitylation K154 0.266 -0.098 _ALYK(gl)AISVPR_
DSP Phosphorylation S2815 -1.038 -0.597 _GLPS(ph)PYNMSSAPGSR_
DSP Phosphorylation S2825 -1.381 -0.714 _GLPSPYNM(ox)SSAPGS(ph)R_
DSP Phosphorylation S2821 -0.690 -0.873 _GLPSPYNMSS(ph)APGSR_
DSP Phosphorylation S2820 -0.905 -0.967 _GLPSPYNMS(ph)SAPGSR_
DSP Ubiquitylation K94 0.120 _AELIVQPELK(gl)YGDGIQLTR_
DSP Ubiquitylation K239 -0.069 _WQLDKIK(gl)_
DSP Ubiquitylation K2811 -0.793 _LLEAASVSSK(gl)GLPSPYNMSSAPGSR_

Background Information for DSP:


Pubmed-DSP »
Uniprot-DSP »
Biogrid-DSP »
ProteomicsDB-DSP »

Tumorportal-DSP »
COSMIC-DSP »
GenomeRNAi-DSP »
Genecards-DSP


Protein-protein Interactions for DSP
Show screen data for Category Name and Description Link to cat description Data Source
Category members IP bait DSP Cat. description Hein, Mann, Cell 2015
Category members IP bait DYNLL1 Cat. description Hein, Mann, Cell 2015
Category members IP bait LMNA Cat. description Hein, Mann, Cell 2015
Category members IP bait SASS6 Cat. description Hein, Mann, Cell 2015
Category members IP bait SEC16A Cat. description Hein, Mann, Cell 2015
Category members IP bait C6orf141 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait CCDC51 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait CDK15 Cat. description BioPlex, Huttlin, Gygi, Cell 2015


Protein Domains in DSP
Domain name Domain Description TC-NER relevance -log10(p-value)
Category members Ubiquitin-rel_dom IPR029071 1.79
Category members Spectrin/alpha-actinin IPR018159 1.6
Category members Plectin_repeat IPR001101 0.1


Protein complexes (CORUM database) featuring DSP
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)


Categories featuring DSP
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)
Category members DDR Literature pubmedid:24332808 Marechal et al., 2014 RPA-mediated recruitment INF
Category members GO Category GO:0005515 protein binding Database INF
Category members DDR Literature pubmedid:TBD2_UV_increased Elia et al, 2015 UV increased acetylation events Elia et al. INF
Category members GO Category GO:0006921 cellular component disassembly involved in execution phase of apoptosis Database 2.98
Category members Pathway Pathway_876 REACTOME_APOPTOTIC_EXECUTION_PHASE 0 2.5
Category members Pathway Pathway_837 REACTOME_APOPTOSIS 0 2.39
Category members GO Category GO:0006915 apoptotic process Database 2.12
Category members GO Category GO:0005739 mitochondrion Database 1.67
Category members GO Category GO:0005911 cell-cell junction Database 1.4
Category members Pathway Pathway_877 REACTOME_APOPTOTIC_CLEAVAGE_OF_CELLULAR_PROTEINS 0 1.25
Category members GO Category GO:0005886 plasma membrane Database 1.21
Category members GO Category GO:0005198 structural molecule activity Database 0.94
Category members GO Category GO:0014704 intercalated disc Database 0.64
Category members GO Category GO:0005856 cytoskeleton Database 0.63
Category members GO Category GO:0018149 peptide cross-linking Database 0.62
Category members GO Category GO:0005916 fascia adherens Database 0.47
Category members GO Category GO:0030057 desmosome Database 0.26
Category members GO Category GO:0030674 protein binding, bridging Database 0.25
Category members Pathway Pathway_294 PID_AJDISS_2PATHWAY 0 0.18
Category members Pathway Pathway_1019 REACTOME_APOPTOTIC_CLEAVAGE_OF_CELL_ADHESION_PROTEINS 0 0.17
Category members Disease phenotype Keratosis_palmoplantaris_striata Keratosis palmoplantaris striata Database 0.15
Category members GO Category GO:0001533 cornified envelope Database 0.09
Category members Disease phenotype Familial_isolated_arrhythmogenic_ventricular_dysplasia_biventricular_form Familial isolated arrhythmogenic ventricular dysplasia biventricular form Database 0.05
Category members Disease phenotype Familial_isolated_arrhythmogenic_ventricular_dysplasia_left_dominant_form Familial isolated arrhythmogenic ventricular dysplasia left dominant form Database 0.05
Category members Disease phenotype Familial_isolated_arrhythmogenic_ventricular_dysplasia_right_dominant_form Familial isolated arrhythmogenic ventricular dysplasia right dominant form Database 0.05
Category members GO Category GO:0005080 protein kinase C binding Database 0.04
Category members GO Category GO:0016323 basolateral plasma membrane Database 0.04
Category members Pathway Pathway_1007 KEGG_ARRHYTHMOGENIC_RIGHT_VENTRICULAR_CARDIOMYOPATHY_ARVC 0 0.03
Category members Disease phenotype Idiopathic_pulmonary_fibrosis Idiopathic pulmonary fibrosis Database 0
Category members GO Category GO:0002934 desmosome organization Database 0
Category members GO Category GO:0003223 ventricular compact myocardium morphogenesis Database 0
Category members GO Category GO:0005200 structural constituent of cytoskeleton Database 0
Category members GO Category GO:0005882 intermediate filament Database 0
Category members GO Category GO:0008544 epidermis development Database 0
Category members GO Category GO:0016337 cell-cell adhesion Database 0
Category members GO Category GO:0030216 keratinocyte differentiation Database 0
Category members GO Category GO:0034332 adherens junction organization Database 0
Category members GO Category GO:0042060 wound healing Database 0
Category members GO Category GO:0043588 skin development Database 0
Category members GO Category GO:0045104 intermediate filament cytoskeleton organization Database 0
Category members GO Category GO:0045109 intermediate filament organization Database 0
Category members GO Category GO:0050839 cell adhesion molecule binding Database 0


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