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Query: DSG1

RNAi screen result RNAPII IP (PI) CSB IP CSB IP (PI) Chrom. Chrom. (PI) Phosphorylation Ubiquitylation
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[Click on the plots to view the data selection in the respective scatterplot]

Protein Results:

 Results for post-translational modifications: see below | Red/green: hit at lower/upper end of the respective screen
Gene name Point score Z-score sums RNAi high RNAi low RNAPII-IP (PI) CSB-IP CSB-IP (PI) Chrom. Chrom. (PI)
DSG1 0 -10.845 1.050 -0.690 -4.325

PTM Sites:

 Back to Protein Results | Red/green: hit at lower/upper end of the respective screen
Gene name PTM type PTM site UV UV (PI) Sequence

Background Information for DSG1:


Pubmed-DSG1 »
Uniprot-DSG1 »
Biogrid-DSG1 »
ProteomicsDB-DSG1 »

Tumorportal-DSG1 »
COSMIC-DSG1 »
GenomeRNAi-DSG1 »
Genecards-DSG1


Protein-protein Interactions for DSG1
Show screen data for Category Name and Description Link to cat description Data Source
Category members IP bait IQGAP1 Cat. description Hein, Mann, Cell 2015
Category members IP bait PLK1 Cat. description Hein, Mann, Cell 2015
Category members IP bait SAMD1 Cat. description Hein, Mann, Cell 2015
Category members IP bait WIPI2 Cat. description Hein, Mann, Cell 2015
Category members IP bait C21orf59 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait CCDC51 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait PI4KA Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait TBC1D22B Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait VAV1 Cat. description BioPlex, Huttlin, Gygi, Cell 2015


Protein Domains in DSG1
Domain name Domain Description TC-NER relevance -log10(p-value)
Category members Cadherin IPR002126 0.32
Category members Cadherin_cytoplasmic-dom IPR000233 0.29
Category members Desmosomal_cadherin IPR009122 0.28
Category members Cadherin-like IPR015919 0.21
Category members Desmoglein IPR009123 0


Protein complexes (CORUM database) featuring DSG1
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)


Categories featuring DSG1
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)
Category members GO Category GO:0005829 cytosol Database INF
Category members GO Category GO:0016021 integral to membrane Database 7.67
Category members DDR Literature pubmedid:19647519 Paulsen et al., 2009 siRNA screen for g-H2A.x phosphorylation 3.6
Category members GO Category GO:0006921 cellular component disassembly involved in execution phase of apoptosis Database 2.98
Category members Pathway Pathway_876 REACTOME_APOPTOTIC_EXECUTION_PHASE 0 2.5
Category members Pathway Pathway_837 REACTOME_APOPTOSIS 0 2.39
Category members GO Category GO:0006915 apoptotic process Database 2.12
Category members GO Category GO:0005911 cell-cell junction Database 1.4
Category members Pathway Pathway_877 REACTOME_APOPTOTIC_CLEAVAGE_OF_CELLULAR_PROTEINS 0 1.25
Category members GO Category GO:0005886 plasma membrane Database 1.21
Category members GO Category GO:0016020 membrane Database 0.52
Category members GO Category GO:0016328 lateral plasma membrane Database 0.41
Category members GO Category GO:0007043 cell-cell junction assembly Database 0.31
Category members GO Category GO:0007156 homophilic cell adhesion Database 0.28
Category members GO Category GO:0030057 desmosome Database 0.26
Category members GO Category GO:0045295 gamma-catenin binding Database 0.23
Category members Pathway Pathway_1019 REACTOME_APOPTOTIC_CLEAVAGE_OF_CELL_ADHESION_PROTEINS 0 0.17
Category members Disease phenotype Keratosis_palmoplantaris_striata Keratosis palmoplantaris striata Database 0.15
Category members GO Category GO:0005509 calcium ion binding Database 0.11
Category members GO Category GO:0032570 response to progesterone Database 0.1
Category members GO Category GO:0050821 protein stabilization Database 0.04
Category members GO Category GO:0009898 cytoplasmic side of plasma membrane Database 0
Category members GO Category GO:0015643 toxic substance binding Database 0
Category members GO Category GO:0016324 apical plasma membrane Database 0
Category members GO Category GO:0016337 cell-cell adhesion Database 0
Category members GO Category GO:0016339 calcium-dependent cell-cell adhesion Database 0
Category members GO Category GO:0060135 maternal process involved in female pregnancy Database 0


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