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Query: DOT1L

RNAi screen result RNAPII IP (PI) CSB IP CSB IP (PI) Chrom. Chrom. (PI) Phosphorylation Ubiquitylation
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[Click on the plots to view the data selection in the respective scatterplot]

Protein Results:

 Results for post-translational modifications: see below | Red/green: hit at lower/upper end of the respective screen
Gene name Point score Z-score sums RNAi high RNAi low RNAPII-IP (PI) CSB-IP CSB-IP (PI) Chrom. Chrom. (PI)
DOT1L 1 2.066 -0.340 0.210 -0.710 -0.145

PTM Sites:

 Back to Protein Results | Red/green: hit at lower/upper end of the respective screen
Gene name PTM type PTM site UV UV (PI) Sequence
DOT1L Phosphorylation S1246 1.598 1.113 _STFS(ph)PISDIGLAK_
DOT1L Phosphorylation S448 0.637 0.950 _KNQTALDALHAQTVSQTAASS(ph)PQDAYR_
DOT1L Phosphorylation S374 -0.107 -0.003 _VAGPADAPMDS(ph)GAEEEK_
DOT1L Phosphorylation S1035 -0.512 -0.045 _GDLPSDSGFS(ph)DPESEAK_
DOT1L Phosphorylation S1104 0.384 -0.103 _RASAGTPSLSAGVS(ph)PK_
DOT1L Phosphorylation S1213 0.118 -0.125 _IATISLESKS(ph)PPK_
DOT1L Phosphorylation S775 0.015 -0.688 _LSGLAAPDYTRLS(ph)PAK_
DOT1L Phosphorylation S834 -1.490 -1.900 _PLS(ph)PGALQLAGEK_
DOT1L Phosphorylation T772 0.095 _LSGLAAPDYT(ph)RLSPAK_

Background Information for DOT1L:


Pubmed-DOT1L »
Uniprot-DOT1L »
Biogrid-DOT1L »
ProteomicsDB-DOT1L »

Tumorportal-DOT1L »
COSMIC-DOT1L »
GenomeRNAi-DOT1L »
Genecards-DOT1L


Protein-protein Interactions for DOT1L
Show screen data for Category Name and Description Link to cat description Data Source
Category members IP bait C9orf126;SCAI Cat. description Hein, Mann, Cell 2015
Category members IP bait CBX1 Cat. description Hein, Mann, Cell 2015
Category members IP bait CKAP5 Cat. description Hein, Mann, Cell 2015
Category members IP bait DOT1L Cat. description Hein, Mann, Cell 2015
Category members IP bait ESPL1 Cat. description Hein, Mann, Cell 2015
Category members IP bait KIF24 Cat. description Hein, Mann, Cell 2015
Category members IP bait MLLT1 Cat. description Hein, Mann, Cell 2015
Category members IP bait NPM1 Cat. description Hein, Mann, Cell 2015
Category members IP bait ORC1 Cat. description Hein, Mann, Cell 2015
Category members IP bait RBM45 Cat. description Hein, Mann, Cell 2015
Category members IP bait VWA9 Cat. description Hein, Mann, Cell 2015
Category members IP bait YEATS4 Cat. description Hein, Mann, Cell 2015
Category members IP bait MLLT6 Cat. description BioPlex, Huttlin, Gygi, Cell 2015


Protein Domains in DOT1L
Domain name Domain Description TC-NER relevance -log10(p-value)
Category members SAM-dependent_MTases-like IPR029063 0.04


Protein complexes (CORUM database) featuring DOT1L
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)


Categories featuring DOT1L
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)
Category members GO Category GO:0005515 protein binding Database INF
Category members GO Category GO:0005634 nucleus Database INF
Category members GO Category GO:0003677 DNA binding Database 1.53
Category members GO Category GO:0034968 histone lysine methylation Database 1.1
Category members Pathway Pathway_22 KEGG_LYSINE_DEGRADATION 0 0.8
Category members GO Category GO:0018024 histone-lysine N-methyltransferase activity Database 0.73
Category members GO Category GO:0008134 transcription factor binding Database 0.37
Category members GO Category GO:0016571 histone methylation Database 0.08
Category members GO Category GO:0046425 regulation of JAK-STAT cascade Database 0.08
Category members GO Category GO:0042054 histone methyltransferase activity Database 0


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