bioLOGIC Data » bioLOGIC CategoryView » bioLOGIC VennView » Experimental Details »

bioLOGIC Data

bioLOGIC Data


Exact search


Query: DIAPH1

This is a cancer-associated gene according to the Broad cancer gene census.

RNAi screen result RNAPII IP (PI) CSB IP CSB IP (PI) Chrom. Chrom. (PI) Phosphorylation Ubiquitylation
W
[Click on the plots to view the data selection in the respective scatterplot]

Protein Results:

 Results for post-translational modifications: see below | Red/green: hit at lower/upper end of the respective screen
Gene name Point score Z-score sums RNAi high RNAi low RNAPII-IP (PI) CSB-IP CSB-IP (PI) Chrom. Chrom. (PI)
DIAPH1 0 1.726 0.480 -0.910 -0.053 -0.130 0.367

PTM Sites:

 Back to Protein Results | Red/green: hit at lower/upper end of the respective screen
Gene name PTM type PTM site UV UV (PI) Sequence
DIAPH1 Ubiquitylation K504 0.243 0.685 _HELQVEM(ox)KK(gl)_
DIAPH1 Ubiquitylation K503 0.696 0.481 _HELQVEMK(gl)K_
DIAPH1 Phosphorylation S22 0.053 0.108 _S(ph)PDELPSAGGDGGK_

Background Information for DIAPH1:


Pubmed-DIAPH1 »
Uniprot-DIAPH1 »
Biogrid-DIAPH1 »
ProteomicsDB-DIAPH1 »

Tumorportal-DIAPH1 »
COSMIC-DIAPH1 »
GenomeRNAi-DIAPH1 »
Genecards-DIAPH1


Protein-protein Interactions for DIAPH1
Show screen data for Category Name and Description Link to cat description Data Source
Category members IP bait DIAPH1 Cat. description Hein, Mann, Cell 2015
Category members IP bait DCAF7 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait PFN2 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait RHOC Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait RHOD Cat. description BioPlex, Huttlin, Gygi, Cell 2015


Protein Domains in DIAPH1
Domain name Domain Description TC-NER relevance -log10(p-value)
Category members ARM-type_fold IPR016024 9.26
Category members Formin_homology_1 IPR009408 0.11
Category members tRNA-bd_arm IPR010978 0.08
Category members FH3_dom IPR010472 0.03
Category members GTPase-bd IPR010473 0.03
Category members Drf_DAD IPR010465 0
Category members FH2_Formin IPR015425 0


Protein complexes (CORUM database) featuring DIAPH1
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)


Categories featuring DIAPH1
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)
Category members GO Category GO:0005515 protein binding Database INF
Category members GO Category GO:0005737 cytoplasm Database 12.81
Category members GO Category GO:0005488 binding Database 9.32
Category members GO Category GO:0000166 nucleotide binding Database 5.91
Category members GO Category GO:0003779 actin binding Database 5.41
Category members Pathway Pathway_924 PID_ILK_PATHWAY 0 1.75
Category members Pathway Pathway_466 PID_ECADHERIN_STABILIZATION_PATHWAY 0 1.4
Category members Human mutations Broad_cancer_genes Broad cancer genes (Lawrence et al., 2014) literature 1.14
Category members Pathway Pathway_595 KEGG_FOCAL_ADHESION 0 1.08
Category members GO Category GO:0030036 actin cytoskeleton organization Database 1.08
Category members GO Category GO:0017048 Rho GTPase binding Database 0.69
Category members GO Category GO:0032587 ruffle membrane Database 0.65
Category members GO Category GO:0005522 profilin binding Database 0.44
Category members Pathway Pathway_667 BIOCARTA_RHO_PATHWAY 0 0.3
Category members GO Category GO:0032886 regulation of microtubule-based process Database 0.29
Category members GO Category GO:0042802 identical protein binding Database 0.26
Category members Pathway Pathway_536 BIOCARTA_ECM_PATHWAY 0 0.25
Category members GO Category GO:0035372 protein localization to microtubule Database 0.23
Category members GO Category GO:0031175 neuron projection development Database 0.12
Category members Pathway Pathway_580 KEGG_REGULATION_OF_ACTIN_CYTOSKELETON 0 0.08
Category members GO Category GO:0043005 neuron projection Database 0.08
Category members GO Category GO:0071420 cellular response to histamine Database 0.04
Category members GO Category GO:0044325 ion channel binding Database 0.03
Category members GO Category GO:0016043 cellular component organization Database 0.03
Category members GO Category GO:0030041 actin filament polymerization Database 0.01
Category members Pathway Pathway_1040 BIOCARTA_MAL_PATHWAY 0 0
Category members Pathway Pathway_668 PID_RHOA_PATHWAY 0 0
Category members Disease phenotype Autosomal_dominant_nonsyndromic_sensorineural_deafness_type_DFNA Autosomal dominant nonsyndromic sensorineural deafness type DFNA Database 0
Category members GO Category GO:0005102 receptor binding Database 0
Category members GO Category GO:0007010 cytoskeleton organization Database 0
Category members GO Category GO:0007605 sensory perception of sound Database 0
Category members GO Category GO:0008360 regulation of cell shape Database 0
Category members GO Category GO:0030335 positive regulation of cell migration Database 0
Category members GO Category GO:0051279 regulation of release of sequestered calcium ion into cytosol Database 0


.

© Copyright Svejstrup Laboratory 2015