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Query: CREB3L2

This is a cancer-associated gene according to the Sanger cancer gene census.

RNAi screen result RNAPII IP (PI) CSB IP CSB IP (PI) Chrom. Chrom. (PI) Phosphorylation Ubiquitylation
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[Click on the plots to view the data selection in the respective scatterplot]

Protein Results:

 Results for post-translational modifications: see below | Red/green: hit at lower/upper end of the respective screen
Gene name Point score Z-score sums RNAi high RNAi low RNAPII-IP (PI) CSB-IP CSB-IP (PI) Chrom. Chrom. (PI)
CREB3L2 1 4.284 -2.290 4.300

PTM Sites:

 Back to Protein Results | Red/green: hit at lower/upper end of the respective screen
Gene name PTM type PTM site UV UV (PI) Sequence
CREB3L2 Ubiquitylation K364 -0.016 _LQTLVMGK(gl)VSR_

Background Information for CREB3L2:


Pubmed-CREB3L2 »
Uniprot-CREB3L2 »
Biogrid-CREB3L2 »
ProteomicsDB-CREB3L2 »

Tumorportal-CREB3L2 »
COSMIC-CREB3L2 »
GenomeRNAi-CREB3L2 »
Genecards-CREB3L2


Protein-protein Interactions for CREB3L2
Show screen data for Category Name and Description Link to cat description Data Source
Category members IP bait CREB3 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait CREB3L1 Cat. description BioPlex, Huttlin, Gygi, Cell 2015


Protein Domains in CREB3L2
Domain name Domain Description TC-NER relevance -log10(p-value)
Category members bZIP IPR004827 0
Category members TF_DNA-bd IPR008917 0


Protein complexes (CORUM database) featuring CREB3L2
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)


Categories featuring CREB3L2
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)
Category members GO Category GO:0005634 nucleus Database INF
Category members DDR Literature pubmedid:TBD1_UV_decreased Elia et al, 2015 UV decreased acetylation events Elia et al. 10.54
Category members GO Category GO:0016021 integral to membrane Database 7.67
Category members Human mutations Sanger_cancer_genes Sanger cancer genes Database 4.88
Category members DDR Literature pubmedid:19647519 Paulsen et al., 2009 siRNA screen for g-H2A.x phosphorylation 3.6
Category members GO Category GO:0005789 endoplasmic reticulum membrane Database 1.57
Category members GO Category GO:0003677 DNA binding Database 1.53
Category members GO Category GO:0006351 transcription, DNA-templated Database 1.07
Category members GO Category GO:0003700 sequence-specific DNA binding transcription factor activity Database 0.63
Category members GO Category GO:0005783 endoplasmic reticulum Database 0.62
Category members GO Category GO:0006986 response to unfolded protein Database 0.62
Category members Pathway Pathway_32 KEGG_HUNTINGTONS_DISEASE 0 0.46
Category members GO Category GO:0006888 ER to Golgi vesicle-mediated transport Database 0.28
Category members GO Category GO:0045893 positive regulation of transcription, DNA-dependent Database 0.28
Category members Disease phenotype Myxofibrosarcoma Myxofibrosarcoma Database 0.21
Category members GO Category GO:0043565 sequence-specific DNA binding Database 0.18
Category members GO Category GO:0002062 chondrocyte differentiation Database 0.13
Category members Pathway Pathway_177 KEGG_PROSTATE_CANCER 0 0.13
Category members GO Category GO:0035497 cAMP response element binding Database 0.08
Category members GO Category GO:0034976 response to endoplasmic reticulum stress Database 0.06
Category members GO Category GO:0044212 transcription regulatory region DNA binding Database 0
Category members Pathway Pathway_244 KEGG_MELANOGENESIS 0 0
Category members Pathway Pathway_266 KEGG_VASOPRESSIN_REGULATED_WATER_REABSORPTION 0 0
Category members GO Category GO:0006355 regulation of transcription, DNA-dependent Database 0
Category members GO Category GO:0051216 cartilage development Database 0


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