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Query: CIT

RNAi screen result RNAPII IP (PI) CSB IP CSB IP (PI) Chrom. Chrom. (PI) Phosphorylation Ubiquitylation
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[Click on the plots to view the data selection in the respective scatterplot]

Protein Results:

 Results for post-translational modifications: see below | Red/green: hit at lower/upper end of the respective screen
Gene name Point score Z-score sums RNAi high RNAi low RNAPII-IP (PI) CSB-IP CSB-IP (PI) Chrom. Chrom. (PI)
CIT 1 2.946 -1.740 3.570 -1.113 0.349

PTM Sites:

 Back to Protein Results | Red/green: hit at lower/upper end of the respective screen
Gene name PTM type PTM site UV UV (PI) Sequence
CIT Phosphorylation S1971 0.032 _DKS(ph)PGRPLER_
CIT Phosphorylation S440 0.108 -0.025 _SESVVSGLDS(ph)PAK_
CIT Phosphorylation S1940 -2.591 _VASS(ph)PAPPEGPSHPR_

Background Information for CIT:


Pubmed-CIT »
Uniprot-CIT »
Biogrid-CIT »
ProteomicsDB-CIT »

Tumorportal-CIT »
COSMIC-CIT »
GenomeRNAi-CIT »
Genecards-CIT


Protein-protein Interactions for CIT
Show screen data for Category Name and Description Link to cat description Data Source
Category members IP bait ANLN Cat. description Hein, Mann, Cell 2015
Category members IP bait CIT Cat. description Hein, Mann, Cell 2015


Protein Domains in CIT
Domain name Domain Description TC-NER relevance -log10(p-value)
Category members PE/DAG-bd IPR002219 0.63
Category members PH_domain IPR001849 0.14
Category members Tropomyosin IPR000533 0.08
Category members HR1_rho-bd IPR011072 0.07
Category members Kinase-like_dom IPR011009 0.03
Category members Prot_kinase_dom IPR000719 0
Category members AGC-kinase_C IPR000961 0
Category members Citron IPR001180 0
Category members Ser-Thr/Tyr_kinase_cat_dom IPR001245 0
Category members Ser/Thr_dual-sp_kinase IPR002290 0
Category members Pkinase_C IPR017892 0
Category members Tyr_kinase_cat_dom IPR020635 0


Protein complexes (CORUM database) featuring CIT
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)


Categories featuring CIT
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)
Category members GO Category GO:0005515 protein binding Database INF
Category members GO Category GO:0005737 cytoplasm Database 12.81
Category members GO Category GO:0005524 ATP binding Database 5.54
Category members GO Category GO:0007067 mitosis Database 2.23
Category members GO Category GO:0015629 actin cytoskeleton Database 2.22
Category members GO Category GO:0007091 metaphase/anaphase transition of mitotic cell cycle Database 1.58
Category members GO Category GO:0005886 plasma membrane Database 1.21
Category members GO Category GO:0017048 Rho GTPase binding Database 0.69
Category members GO Category GO:0004674 protein serine/threonine kinase activity Database 0.66
Category members GO Category GO:0000086 G2/M transition of mitotic cell cycle Database 0.33
Category members GO Category GO:0001726 ruffle Database 0.33
Category members GO Category GO:0004672 protein kinase activity Database 0.19
Category members GO Category GO:0000910 cytokinesis Database 0.15
Category members GO Category GO:0007030 Golgi organization Database 0.13
Category members GO Category GO:0031985 Golgi cisterna Database 0.08
Category members GO Category GO:0048699 generation of neurons Database 0.04
Category members GO Category GO:0006468 protein phosphorylation Database 0.04
Category members GO Category GO:0004713 protein tyrosine kinase activity Database 0.01
Category members Pathway Pathway_668 PID_RHOA_PATHWAY 0 0
Category members GO Category GO:0000070 mitotic sister chromatid segregation Database 0
Category members GO Category GO:0005083 small GTPase regulator activity Database 0
Category members GO Category GO:0005773 vacuole Database 0
Category members GO Category GO:0007165 signal transduction Database 0
Category members GO Category GO:0007283 spermatogenesis Database 0
Category members GO Category GO:0008064 regulation of actin polymerization or depolymerization Database 0
Category members GO Category GO:0016358 dendrite development Database 0
Category members GO Category GO:0016772 transferase activity, transferring phosphorus-containing groups Database 0
Category members GO Category GO:0017124 SH3 domain binding Database 0
Category members GO Category GO:0035556 intracellular signal transduction Database 0
Category members GO Category GO:0043025 neuronal cell body Database 0
Category members GO Category GO:0046872 metal ion binding Database 0
Category members GO Category GO:0050774 negative regulation of dendrite morphogenesis Database 0


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