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Query: CHD4

This is a cancer-associated gene according to the Broad cancer gene census.

RNAi screen result RNAPII IP (PI) CSB IP CSB IP (PI) Chrom. Chrom. (PI) Phosphorylation Ubiquitylation
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[Click on the plots to view the data selection in the respective scatterplot]

Protein Results:

 Results for post-translational modifications: see below | Red/green: hit at lower/upper end of the respective screen
Gene name Point score Z-score sums RNAi high RNAi low RNAPII-IP (PI) CSB-IP CSB-IP (PI) Chrom. Chrom. (PI)
CHD4 0 4.353 0.740 -0.710 -2.910 -0.998 -0.326
CHD4 0 4.353 0.740 -0.710 0.187 0.222 0.572 0.098 0.155

PTM Sites:

 Back to Protein Results | Red/green: hit at lower/upper end of the respective screen
Gene name PTM type PTM site UV UV (PI) Sequence
CHD4 Phosphorylation S1544 1.206 1.130 _IEENS(ph)LKEEESIEGEK_
CHD4 Ubiquitylation K1778 0.999 _GNFLEIK(gl)NK_
CHD4 Ubiquitylation K1780 0.999 _GNFLEIK(gl)NK_
CHD4 Ubiquitylation K884 0.702 _NNQSK(gl)FFR_
CHD4 Phosphorylation S402 0.539 _EGIQWEAKEDNS(ph)EGEEILEEVGGDLEEEDDHHMEFCR_
CHD4 Phosphorylation S1509 -0.565 -0.704 _MSQPGS(ph)PSPK_
CHD4 Phosphorylation T1514 -1.082 _T(ph)PTPSTPGDTQPNTPAPVPPAEDGIK_
CHD4 Phosphorylation T1519 -1.446 _TPTPST(ph)PGDTQPNTPAPVPPAEDGIK_
CHD4 Phosphorylation S489 -1.030 -2.127 _WGQPPS(ph)PTPVPRPPDADPNTPSPK_
CHD4 Phosphorylation T1527 -2.218 -2.475 _TPTPS(ph)TPGDTQPNT(ph)PAPVPPAEDGIK_
CHD4 Phosphorylation T491 -2.659 _WGQPPS(ph)PTPVPRPPDADPNTPSPK_
CHD4 Ubiquitylation K959 -0.609 _LK(gl)ADVFK_
CHD4 Ubiquitylation K1844 -0.796 _ESMAGNK(gl)PANAVLHK_
CHD4 Ubiquitylation K1865 -0.216 _QLEELLSDMK(gl)ADVTR_

Background Information for CHD4:


Pubmed-CHD4 »
Uniprot-CHD4 »
Biogrid-CHD4 »
ProteomicsDB-CHD4 »

Tumorportal-CHD4 »
COSMIC-CHD4 »
GenomeRNAi-CHD4 »
Genecards-CHD4


Protein-protein Interactions for CHD4
Show screen data for Category Name and Description Link to cat description Data Source
Category members IP bait CBX1 Cat. description Hein, Mann, Cell 2015
Category members IP bait CDK2AP1 Cat. description Hein, Mann, Cell 2015
Category members IP bait HDAC1 Cat. description Hein, Mann, Cell 2015
Category members IP bait MBD2 Cat. description Hein, Mann, Cell 2015
Category members IP bait MTA1 Cat. description Hein, Mann, Cell 2015
Category members IP bait MTA2 Cat. description Hein, Mann, Cell 2015
Category members IP bait SRP72 Cat. description Hein, Mann, Cell 2015
Category members IP bait ZMYND8 Cat. description Hein, Mann, Cell 2015
Category members IP bait CPNE5 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait CTBP1 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait GATAD2A Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait GATAD2B Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait HDAC1 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait HSFY1 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait IKZF1 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait MBD3L1 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait PHF20L1 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait RBBP7 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait SNRNP27 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait ZNF219 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait ZNF524 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait ZNF581 Cat. description BioPlex, Huttlin, Gygi, Cell 2015


Protein Domains in CHD4
Domain name Domain Description TC-NER relevance -log10(p-value)
Category members SNF2_N IPR000330 3.38
Category members Chromo_domain/shadow IPR000953 2.84
Category members P-loop_NTPase IPR027417 2.83
Category members Helicase_C IPR001650 2.48
Category members Helicase_ATP-bd IPR014001 2.48
Category members Chromodomain-like IPR016197 2.29
Category members Chromo_domain IPR023780 1.98
Category members Znf_FYVE_PHD IPR011011 1.23
Category members Znf_PHD IPR001965 1.15
Category members Znf_PHD-finger IPR019787 0.91
Category members Helicase/UvrB_dom IPR006935 0.78
Category members DUF1086 IPR009462 0.46
Category members DUF1087 IPR009463 0.46
Category members CHD_C2 IPR012957 0.46
Category members CHD_N IPR012958 0.46
Category members HMG_box_dom IPR009071 0.31
Category members HDA_complex_subunit-2/3 IPR021006 0.04
Category members Homeodomain-like IPR009057 0


Protein complexes (CORUM database) featuring CHD4
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)
Category members Corum 778 LARC complex (LCR-associated remodeling complex) Database 5.04
Category members Corum 659 MeCP1 complex Database 4.17
Category members Corum 685 MeCP1 complex Database 4.17
Category members Corum 62 MeCP1 complex Database 3.53
Category members Corum 61 Mi2/NuRD complex Database 2.87
Category members Corum 614 NRD complex (Nucleosome remodeling and deacetylation complex) Database 2.26
Category members Corum 888 MTA2 complex Database 2.24
Category members Corum 632 Anti-HDAC2 complex Database 2.11
Category members Corum 1495 PID complex Database 1.68
Category members Corum 5614 Emerin complex 32 Database 1.48
Category members Corum 1134 ATR-HDAC2-CHD4 complex Database 0.77
Category members Corum 585 Mi2/NuRD-BCL6-MTA3 complex Database 0.67


Categories featuring CHD4
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)
Category members DDR Literature pubmedid:24332808 Marechal et al., 2014 RPA-mediated recruitment INF
Category members GO Category GO:0005515 protein binding Database INF
Category members GO Category GO:0005634 nucleus Database INF
Category members GO Category GO:0005737 cytoplasm Database 12.81
Category members GO Category GO:0005524 ATP binding Database 5.54
Category members GO Category GO:0004003 ATP-dependent DNA helicase activity Database 4.66
Category members GO Category GO:0043234 protein complex Database 2.73
Category members GO Category GO:0004386 helicase activity Database 2.49
Category members GO Category GO:0016818 hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides Database 1.64
Category members GO Category GO:0003677 DNA binding Database 1.53
Category members GO Category GO:0016581 NuRD complex Database 1.15
Category members Human mutations Broad_cancer_genes Broad cancer genes (Lawrence et al., 2014) literature 1.14
Category members Pathway Pathway_943 PID_HDAC_CLASSI_PATHWAY 0 1.08
Category members GO Category GO:0006351 transcription, DNA-templated Database 1.07
Category members GO Category GO:0003676 nucleic acid binding Database 0.83
Category members GO Category GO:0008026 ATP-dependent helicase activity Database 0.79
Category members GO Category GO:0005813 centrosome Database 0.75
Category members GO Category GO:0008134 transcription factor binding Database 0.37
Category members GO Category GO:0001103 RNA polymerase II repressing transcription factor binding Database 0.36
Category members GO Category GO:0008270 zinc ion binding Database 0.29
Category members GO Category GO:0016787 hydrolase activity Database 0.22
Category members GO Category GO:0006357 regulation of transcription from RNA polymerase II promoter Database 0.19
Category members GO Category GO:0016568 chromatin modification Database 0.18
Category members GO Category GO:0006355 regulation of transcription, DNA-dependent Database 0


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