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Query: BRE

This is a cancer-associated gene according to the Broad cancer gene census.

RNAi screen result RNAPII IP (PI) CSB IP CSB IP (PI) Chrom. Chrom. (PI) Phosphorylation Ubiquitylation
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[Click on the plots to view the data selection in the respective scatterplot]

Protein Results:

 Results for post-translational modifications: see below | Red/green: hit at lower/upper end of the respective screen
Gene name Point score Z-score sums RNAi high RNAi low RNAPII-IP (PI) CSB-IP CSB-IP (PI) Chrom. Chrom. (PI)
BRE 0 1.490 -1.690 2.290 0.053 0.191 -0.048 0.149
BRE 0 1.490 -1.690 2.290 -1.215

PTM Sites:

 Back to Protein Results | Red/green: hit at lower/upper end of the respective screen
Gene name PTM type PTM site UV UV (PI) Sequence
BRE Ubiquitylation K162 0.838 _K(gl)NNWTGEFSAR_
BRE Ubiquitylation K41 -0.768 -0.586 _ITDLK(gl)SGCTSLTPGPNCDR_
BRE Ubiquitylation K26 -0.928 _NGK(gl)VGLDATNCLR_

Background Information for BRE:


Pubmed-BRE »
Uniprot-BRE »
Biogrid-BRE »
ProteomicsDB-BRE »

Tumorportal-BRE »
COSMIC-BRE »
GenomeRNAi-BRE »
Genecards-BRE


Protein-protein Interactions for BRE
Show screen data for Category Name and Description Link to cat description Data Source
Category members IP bait TNKS2 Cat. description Hein, Mann, Cell 2015
Category members IP bait BABAM1 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait BRE Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait DEF6 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait FAM189B Cat. description BioPlex, Huttlin, Gygi, Cell 2015


Protein Domains in BRE
Domain name Domain Description TC-NER relevance -log10(p-value)


Protein complexes (CORUM database) featuring BRE
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)
Category members Corum 5400 BRCC complex Database 0


Categories featuring BRE
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)
Category members GO Category GO:0005515 protein binding Database INF
Category members GO Category GO:0005634 nucleus Database INF
Category members GO Category GO:0005737 cytoplasm Database 12.81
Category members GO Category GO:0006302 double-strand break repair Database 4.62
Category members GO Category GO:0006974 cellular response to DNA damage stimulus Database 3.57
Category members GO Category GO:0006915 apoptotic process Database 2.12
Category members GO Category GO:0010212 response to ionizing radiation Database 1.66
Category members Human mutations Broad_cancer_genes Broad cancer genes (Lawrence et al., 2014) literature 1.14
Category members GO Category GO:0031593 polyubiquitin binding Database 0.38
Category members GO Category GO:0016568 chromatin modification Database 0.18
Category members GO Category GO:0005164 tumor necrosis factor receptor binding Database 0.08
Category members GO Category GO:0070531 BRCA1-A complex Database 0.04
Category members GO Category GO:0045739 positive regulation of DNA repair Database 0.04
Category members GO Category GO:0000152 nuclear ubiquitin ligase complex Database 0
Category members GO Category GO:0000268 peroxisome targeting sequence binding Database 0
Category members GO Category GO:0007165 signal transduction Database 0
Category members GO Category GO:0031572 G2 DNA damage checkpoint Database 0
Category members GO Category GO:0070552 BRISC complex Database 0


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