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Query: ATIC

This is a cancer-associated gene according to the Sanger cancer gene census.

RNAi screen result RNAPII IP (PI) CSB IP CSB IP (PI) Chrom. Chrom. (PI) Phosphorylation Ubiquitylation
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[Click on the plots to view the data selection in the respective scatterplot]

Protein Results:

 Results for post-translational modifications: see below | Red/green: hit at lower/upper end of the respective screen
Gene name Point score Z-score sums RNAi high RNAi low RNAPII-IP (PI) CSB-IP CSB-IP (PI) Chrom. Chrom. (PI)
ATIC 0 1.610 -0.830 0.480 -0.329 0.553

PTM Sites:

 Back to Protein Results | Red/green: hit at lower/upper end of the respective screen
Gene name PTM type PTM site UV UV (PI) Sequence
ATIC Ubiquitylation K408 0.438 0.468 _SLFSNVVTKNK(gl)_
ATIC Ubiquitylation K406 0.213 0.405 _SLFSNVVTK(gl)NK_
ATIC Ubiquitylation K199 -0.427 -0.247 _QYSK(gl)GVSQMPLR_
ATIC Ubiquitylation K195 -0.448 _K(gl)QYSKGVSQMPLR_
ATIC Ubiquitylation K397 0.429 _NNGVVDK(gl)SLFSNVVTK_

Background Information for ATIC:


Pubmed-ATIC »
Uniprot-ATIC »
Biogrid-ATIC »
ProteomicsDB-ATIC »

Tumorportal-ATIC »
COSMIC-ATIC »
GenomeRNAi-ATIC »
Genecards-ATIC


Protein-protein Interactions for ATIC
Show screen data for Category Name and Description Link to cat description Data Source


Protein Domains in ATIC
Domain name Domain Description TC-NER relevance -log10(p-value)
Category members Cytidine_deaminase-like IPR016193 0.07
Category members MGS-like_dom IPR011607 0


Protein complexes (CORUM database) featuring ATIC
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)


Categories featuring ATIC
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)
Category members GO Category GO:0005829 cytosol Database INF
Category members Human mutations Sanger_cancer_genes Sanger cancer genes Database 4.88
Category members GO Category GO:0005739 mitochondrion Database 1.67
Category members GO Category GO:0021987 cerebral cortex development Database 0.37
Category members GO Category GO:0044281 small molecule metabolic process Database 0.35
Category members Pathway Pathway_273 REACTOME_PURINE_RIBONUCLEOSIDE_MONOPHOSPHATE_BIOSYNTHESIS 0 0.23
Category members Pathway Pathway_68 KEGG_PURINE_METABOLISM 0 0.23
Category members Pathway Pathway_204 REACTOME_PURINE_METABOLISM 0 0.22
Category members GO Category GO:0021549 cerebellum development Database 0.14
Category members GO Category GO:0006189 'de novo' IMP biosynthetic process Database 0.13
Category members GO Category GO:0009168 purine ribonucleoside monophosphate biosynthetic process Database 0.12
Category members Pathway Pathway_275 KEGG_ONE_CARBON_POOL_BY_FOLATE 0 0.11
Category members GO Category GO:0006144 purine nucleobase metabolic process Database 0.11
Category members GO Category GO:0003824 catalytic activity Database 0.11
Category members GO Category GO:0006139 nucleobase-containing compound metabolic process Database 0.08
Category members GO Category GO:0031100 organ regeneration Database 0.01
Category members Pathway Pathway_206 REACTOME_METABOLISM_OF_NUCLEOTIDES 0 0
Category members GO Category GO:0003360 brainstem development Database 0
Category members GO Category GO:0006164 purine nucleotide biosynthetic process Database 0
Category members GO Category GO:0009116 nucleoside metabolic process Database 0
Category members GO Category GO:0009259 ribonucleotide metabolic process Database 0
Category members GO Category GO:0010035 response to inorganic substance Database 0
Category members GO Category GO:0042803 protein homodimerization activity Database 0
Category members GO Category GO:0046654 tetrahydrofolate biosynthetic process Database 0
Category members GO Category GO:0055086 nucleobase-containing small molecule metabolic process Database 0


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