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Query: ARFGEF2

RNAi screen result RNAPII IP (PI) CSB IP CSB IP (PI) Chrom. Chrom. (PI) Phosphorylation Ubiquitylation
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[Click on the plots to view the data selection in the respective scatterplot]

Protein Results:

 Results for post-translational modifications: see below | Red/green: hit at lower/upper end of the respective screen
Gene name Point score Z-score sums RNAi high RNAi low RNAPII-IP (PI) CSB-IP CSB-IP (PI) Chrom. Chrom. (PI)
ARFGEF2 1 5.425 -0.840 1.310 2.230

PTM Sites:

 Back to Protein Results | Red/green: hit at lower/upper end of the respective screen
Gene name PTM type PTM site UV UV (PI) Sequence
ARFGEF2 Phosphorylation S276 0.922 0.963 _GS(ph)SLSGTDDGAQEVVK_
ARFGEF2 Phosphorylation S277 0.851 0.904 _GSS(ph)LSGTDDGAQEVVK_
ARFGEF2 Phosphorylation S1528 -0.424 0.473 _GQSQLS(ph)NPTDDSWK_
ARFGEF2 Phosphorylation S218 -0.081 0.177 _ELEKPIQSKPQS(ph)PVIQAAAVS(ph)PK_
ARFGEF2 Phosphorylation S227 -1.086 -0.941 _ELEKPIQSKPQS(ph)PVIQAAAVS(ph)PK_
ARFGEF2 Phosphorylation S214 0.250 _ELEKPIQS(ph)KPQSPVIQAAAVS(ph)PK_

Background Information for ARFGEF2:


Pubmed-ARFGEF2 »
Uniprot-ARFGEF2 »
Biogrid-ARFGEF2 »
ProteomicsDB-ARFGEF2 »

Tumorportal-ARFGEF2 »
COSMIC-ARFGEF2 »
GenomeRNAi-ARFGEF2 »
Genecards-ARFGEF2


Protein-protein Interactions for ARFGEF2
Show screen data for Category Name and Description Link to cat description Data Source
Category members IP bait C19orf75 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait CD244 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait CD79B Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait CSGALNACT1 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait EDNRB Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait FAM131B Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait GYPB Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait HLA-B Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait ICAM1 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait LAMP3 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait MADCAM1 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait MRAP2 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait PDCD1 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait SDF4 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait TMEM9B Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait VASN Cat. description BioPlex, Huttlin, Gygi, Cell 2015


Protein Domains in ARFGEF2
Domain name Domain Description TC-NER relevance -log10(p-value)
Category members ARM-type_fold IPR016024 9.26
Category members Sec7_dom IPR000904 0
Category members DUF1981_Sec7_assoc IPR015403 0


Protein complexes (CORUM database) featuring ARFGEF2
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)


Categories featuring ARFGEF2
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)
Category members GO Category GO:0005515 protein binding Database INF
Category members GO Category GO:0005829 cytosol Database INF
Category members GO Category GO:0005737 cytoplasm Database 12.81
Category members Pathway Pathway_11 REACTOME_METABOLISM_OF_PROTEINS 0 12.01
Category members GO Category GO:0005488 binding Database 9.32
Category members GO Category GO:0015031 protein transport Database 3.48
Category members GO Category GO:0016192 vesicle-mediated transport Database 1.1
Category members Pathway Pathway_742 REACTOME_PROTEIN_FOLDING 0 0.9
Category members GO Category GO:0043197 dendritic spine Database 0.86
Category members Pathway Pathway_709 BIOCARTA_ARAP_PATHWAY 0 0.76
Category members GO Category GO:0016020 membrane Database 0.52
Category members GO Category GO:0005815 microtubule organizing center Database 0.39
Category members GO Category GO:0048471 perinuclear region of cytoplasm Database 0.39
Category members GO Category GO:0032279 asymmetric synapse Database 0.33
Category members Pathway Pathway_741 REACTOME_ASSOCIATION_OF_TRIC_CCT_WITH_TARGET_PROTEINS_DURING_BIOSYNTHESIS 0 0.29
Category members GO Category GO:0055037 recycling endosome Database 0.29
Category members GO Category GO:0006887 exocytosis Database 0.2
Category members Disease phenotype Periventricular_nodular_heterotopia Periventricular nodular heterotopia Database 0.17
Category members GO Category GO:0016023 cytoplasmic membrane-bounded vesicle Database 0.17
Category members GO Category GO:0005802 trans-Golgi network Database 0.13
Category members GO Category GO:0007032 endosome organization Database 0.11
Category members GO Category GO:0001881 receptor recycling Database 0.07
Category members GO Category GO:0000139 Golgi membrane Database 0
Category members GO Category GO:0005085 guanyl-nucleotide exchange factor activity Database 0
Category members GO Category GO:0005086 ARF guanyl-nucleotide exchange factor activity Database 0
Category members GO Category GO:0006893 Golgi to plasma membrane transport Database 0
Category members GO Category GO:0010256 endomembrane system organization Database 0
Category members GO Category GO:0017022 myosin binding Database 0
Category members GO Category GO:0030054 cell junction Database 0
Category members GO Category GO:0031410 cytoplasmic vesicle Database 0
Category members GO Category GO:0032012 regulation of ARF protein signal transduction Database 0
Category members GO Category GO:0032760 positive regulation of tumor necrosis factor production Database 0
Category members GO Category GO:0034237 protein kinase A regulatory subunit binding Database 0
Category members GO Category GO:0035556 intracellular signal transduction Database 0
Category members GO Category GO:0050811 GABA receptor binding Database 0


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