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Query: APPL1

RNAi screen result RNAPII IP (PI) CSB IP CSB IP (PI) Chrom. Chrom. (PI) Phosphorylation Ubiquitylation
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[Click on the plots to view the data selection in the respective scatterplot]

Protein Results:

 Results for post-translational modifications: see below | Red/green: hit at lower/upper end of the respective screen
Gene name Point score Z-score sums RNAi high RNAi low RNAPII-IP (PI) CSB-IP CSB-IP (PI) Chrom. Chrom. (PI)
APPL1 0 0.048 1.130 -0.340

PTM Sites:

 Back to Protein Results | Red/green: hit at lower/upper end of the respective screen
Gene name PTM type PTM site UV UV (PI) Sequence
APPL1 Ubiquitylation K351 -0.236 0.892 _YCFQITSFDGKK(gl)_
APPL1 Ubiquitylation K638 -0.311 0.401 _ASEK(gl)QKEIER_
APPL1 Ubiquitylation K66 -1.174 0.359 _LLK(gl)EYEK_
APPL1 Ubiquitylation K289 0.154 _NK(gl)TGLVSSTWDR_
APPL1 Phosphorylation S401 -0.233 -0.423 _VNQSALEAVTPS(ph)PSFQQR_
APPL1 Ubiquitylation K124 -0.697 _DLK(gl)EILTLK_
APPL1 Phosphorylation T399 -0.185 _VNQSALEAVT(ph)PSPSFQQR_

Background Information for APPL1:


Pubmed-APPL1 »
Uniprot-APPL1 »
Biogrid-APPL1 »
ProteomicsDB-APPL1 »

Tumorportal-APPL1 »
COSMIC-APPL1 »
GenomeRNAi-APPL1 »
Genecards-APPL1


Protein-protein Interactions for APPL1
Show screen data for Category Name and Description Link to cat description Data Source
Category members IP bait APPL1 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait APPL2 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait C16orf70 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait FAM167A Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait GIPC2 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait KLHL2 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait TPCN2 Cat. description BioPlex, Huttlin, Gygi, Cell 2015


Protein Domains in APPL1
Domain name Domain Description TC-NER relevance -log10(p-value)
Category members PH_domain IPR001849 0.14
Category members PTB/PI_dom IPR006020 0


Protein complexes (CORUM database) featuring APPL1
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)
Category members Corum 2159 AR-AKT-APPL complex Database 0


Categories featuring APPL1
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)
Category members GO Category GO:0005515 protein binding Database INF
Category members GO Category GO:0005634 nucleus Database INF
Category members GO Category GO:0005829 cytosol Database INF
Category members GO Category GO:0005737 cytoplasm Database 12.81
Category members Pathway Pathway_837 REACTOME_APOPTOSIS 0 2.39
Category members GO Category GO:0006915 apoptotic process Database 2.12
Category members GO Category GO:0016581 NuRD complex Database 1.15
Category members Pathway Pathway_634 KEGG_COLORECTAL_CANCER 0 0.98
Category members Pathway Pathway_1016 REACTOME_ROLE_OF_DCC_IN_REGULATING_APOPTOSIS 0 0.87
Category members GO Category GO:0042981 regulation of apoptotic process Database 0.79
Category members GO Category GO:0007049 cell cycle Database 0.69
Category members GO Category GO:0031901 early endosome membrane Database 0.58
Category members Pathway Pathway_880 PID_AR_PATHWAY 0 0.58
Category members Pathway Pathway_795 REACTOME_REGULATION_OF_APOPTOSIS 0 0.31
Category members GO Category GO:0042802 identical protein binding Database 0.26
Category members GO Category GO:0043065 positive regulation of apoptotic process Database 0.26
Category members GO Category GO:0008286 insulin receptor signaling pathway Database 0.2
Category members GO Category GO:0043422 protein kinase B binding Database 0.12
Category members GO Category GO:0008283 cell proliferation Database 0.06
Category members GO Category GO:0012506 vesicle membrane Database 0.01
Category members Pathway Pathway_24 KEGG_PATHWAYS_IN_CANCER 0 0
Category members GO Category GO:0007165 signal transduction Database 0
Category members GO Category GO:0010008 endosome membrane Database 0
Category members GO Category GO:0046324 regulation of glucose import Database 0


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