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Query: ALS2

RNAi screen result RNAPII IP (PI) CSB IP CSB IP (PI) Chrom. Chrom. (PI) Phosphorylation Ubiquitylation
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[Click on the plots to view the data selection in the respective scatterplot]

Protein Results:

 Results for post-translational modifications: see below | Red/green: hit at lower/upper end of the respective screen
Gene name Point score Z-score sums RNAi high RNAi low RNAPII-IP (PI) CSB-IP CSB-IP (PI) Chrom. Chrom. (PI)
ALS2 0 3.142 -0.780 1.190

PTM Sites:

 Back to Protein Results | Red/green: hit at lower/upper end of the respective screen
Gene name PTM type PTM site UV UV (PI) Sequence
ALS2 Phosphorylation S466 1.095 0.857 _KSSS(ph)LVDIREEETEGGSR_
ALS2 Phosphorylation S492 0.013 0.308 _LSLPGLLSQVS(ph)PR_
ALS2 Phosphorylation S1462 -0.133 -0.364 _S(ph)ESPEPGYVVTSSGLLLPVLLPR_
ALS2 Phosphorylation S1464 -0.535 -0.600 _SES(ph)PEPGYVVTSSGLLLPVLLPR_

Background Information for ALS2:


Pubmed-ALS2 »
Uniprot-ALS2 »
Biogrid-ALS2 »
ProteomicsDB-ALS2 »

Tumorportal-ALS2 »
COSMIC-ALS2 »
GenomeRNAi-ALS2 »
Genecards-ALS2


Protein-protein Interactions for ALS2
Show screen data for Category Name and Description Link to cat description Data Source
Category members IP bait ALS2 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait C14orf104 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait SDF2 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait STXBP6 Cat. description BioPlex, Huttlin, Gygi, Cell 2015


Protein Domains in ALS2
Domain name Domain Description TC-NER relevance -log10(p-value)
Category members RCC1/BLIP-II IPR009091 0.24
Category members Reg_chr_condens IPR000408 0.23
Category members DH-domain IPR000219 0.05
Category members VPS9 IPR003123 0
Category members MORN IPR003409 0


Protein complexes (CORUM database) featuring ALS2
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)


Categories featuring ALS2
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)
Category members GO Category GO:0005515 protein binding Database INF
Category members GO Category GO:0005829 cytosol Database INF
Category members GO Category GO:0005737 cytoplasm Database 12.81
Category members GO Category GO:0043234 protein complex Database 2.73
Category members GO Category GO:0030027 lamellipodium Database 1.77
Category members GO Category GO:0030426 growth cone Database 1.61
Category members GO Category GO:0005769 early endosome Database 1.26
Category members GO Category GO:0043197 dendritic spine Database 0.86
Category members GO Category GO:0005813 centrosome Database 0.75
Category members GO Category GO:0016020 membrane Database 0.52
Category members GO Category GO:0008104 protein localization Database 0.5
Category members GO Category GO:0043231 intracellular membrane-bounded organelle Database 0.43
Category members GO Category GO:0016197 endosomal transport Database 0.43
Category members Pathway Pathway_420 KEGG_AMYOTROPHIC_LATERAL_SCLEROSIS_ALS 0 0.39
Category members GO Category GO:0001726 ruffle Database 0.33
Category members Disease phenotype Juvenile_amyotrophic_lateral_sclerosis Juvenile amyotrophic lateral sclerosis Database 0.32
Category members GO Category GO:0016050 vesicle organization Database 0.31
Category members GO Category GO:0043539 protein serine/threonine kinase activator activity Database 0.27
Category members GO Category GO:0030425 dendrite Database 0.26
Category members GO Category GO:0035022 positive regulation of Rac protein signal transduction Database 0.26
Category members GO Category GO:0030424 axon Database 0.23
Category members GO Category GO:0001701 in utero embryonic development Database 0.2
Category members GO Category GO:0035023 regulation of Rho protein signal transduction Database 0.17
Category members GO Category GO:0007409 axonogenesis Database 0.13
Category members GO Category GO:0035249 synaptic transmission, glutamatergic Database 0.13
Category members Disease phenotype Juvenile_primary_lateral_sclerosis Juvenile primary lateral sclerosis Database 0.11
Category members GO Category GO:0007032 endosome organization Database 0.11
Category members GO Category GO:0008219 cell death Database 0.08
Category members GO Category GO:0005089 Rho guanyl-nucleotide exchange factor activity Database 0.08
Category members GO Category GO:0001881 receptor recycling Database 0.07
Category members GO Category GO:0045860 positive regulation of protein kinase activity Database 0.06
Category members GO Category GO:0032313 regulation of Rab GTPase activity Database 0.04
Category members GO Category GO:0031982 vesicle Database 0.01
Category members GO Category GO:0001662 behavioral fear response Database 0
Category members GO Category GO:0005085 guanyl-nucleotide exchange factor activity Database 0
Category members GO Category GO:0005087 Ran guanyl-nucleotide exchange factor activity Database 0
Category members GO Category GO:0006979 response to oxidative stress Database 0
Category members GO Category GO:0007528 neuromuscular junction development Database 0
Category members GO Category GO:0007626 locomotory behavior Database 0
Category members GO Category GO:0014069 postsynaptic density Database 0
Category members GO Category GO:0016601 Rac protein signal transduction Database 0
Category members GO Category GO:0017112 Rab guanyl-nucleotide exchange factor activity Database 0
Category members GO Category GO:0017137 Rab GTPase binding Database 0
Category members GO Category GO:0030676 Rac guanyl-nucleotide exchange factor activity Database 0
Category members GO Category GO:0032855 positive regulation of Rac GTPase activity Database 0
Category members GO Category GO:0042803 protein homodimerization activity Database 0
Category members GO Category GO:0043025 neuronal cell body Database 0
Category members GO Category GO:0048812 neuron projection morphogenesis Database 0


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