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Query: ACTR3

RNAi screen result RNAPII IP (PI) CSB IP CSB IP (PI) Chrom. Chrom. (PI) Phosphorylation Ubiquitylation
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[Click on the plots to view the data selection in the respective scatterplot]

Protein Results:

Results for post-translational modifications: see below | Red/green: hit at lower/upper end of the respective screen
Gene name Point score Z-score sums RNAi high RNAi low RNAPII-IP (PI) CSB-IP CSB-IP (PI) Chrom. Chrom. (PI)
ACTR3 0 1.994 1.800 -1.060 0.313 -0.076 0.489 -0.053 -0.011

PTM Sites:

Back to Protein Results | Red/green: hit at lower/upper end of the respective screen
Gene name PTM type PTM site UV UV (PI) Sequence
ACTR3 Ubiquitylation K348 0.619 0.713 _LK(gl)LSEELSGGR_
ACTR3 Ubiquitylation K265 -0.295 _QYTGINAISKK(gl)_
ACTR3 Ubiquitylation K225 -1.054 -1.094 _DREVGIPPEQSLETAK(gl)AVK_
ACTR3 Ubiquitylation K251 -1.416 _EFNKYDTDGSK(gl)WIK_
ACTR3 Ubiquitylation K264 -0.776 _QYTGINAISK(gl)K_

Background Information for ACTR3:





Protein-protein Interactions for ACTR3

Show screen data for Category Name and Description Link to cat description Data Source
Category members IP bait ACTB Cat. description Hein, Mann, Cell 2015
Category members IP bait ACTR2 Cat. description Hein, Mann, Cell 2015
Category members IP bait ANLN Cat. description Hein, Mann, Cell 2015
Category members IP bait CALML3 Cat. description Hein, Mann, Cell 2015
Category members IP bait CAPZA2 Cat. description Hein, Mann, Cell 2015
Category members IP bait CAT Cat. description Hein, Mann, Cell 2015
Category members IP bait CORO1C Cat. description Hein, Mann, Cell 2015
Category members IP bait DBN1 Cat. description Hein, Mann, Cell 2015
Category members IP bait FLNA Cat. description Hein, Mann, Cell 2015
Category members IP bait IQGAP1 Cat. description Hein, Mann, Cell 2015
Category members IP bait ITGA5 Cat. description Hein, Mann, Cell 2015
Category members IP bait MYH10 Cat. description Hein, Mann, Cell 2015
Category members IP bait MYH11 Cat. description Hein, Mann, Cell 2015
Category members IP bait MYH9 Cat. description Hein, Mann, Cell 2015
Category members IP bait MYO18A Cat. description Hein, Mann, Cell 2015
Category members IP bait MYO19 Cat. description Hein, Mann, Cell 2015
Category members IP bait MYO1C Cat. description Hein, Mann, Cell 2015
Category members IP bait MYO5C Cat. description Hein, Mann, Cell 2015
Category members IP bait PDLIM7 Cat. description Hein, Mann, Cell 2015
Category members IP bait PPP1CB Cat. description Hein, Mann, Cell 2015
Category members IP bait SYNPO Cat. description Hein, Mann, Cell 2015
Category members IP bait TPM1 Cat. description Hein, Mann, Cell 2015
Category members IP bait ACTR3 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait ACTR3B Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait ARPC1A Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait ARPC1B Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait ARPC3 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait ARPC5 Cat. description BioPlex, Huttlin, Gygi, Cell 2015


Protein Domains in ACTR3

Domain name Domain Description TC-NER relevance -log10(p-value)
Category members Actin-related IPR004000 0.11


Protein complexes (CORUM database) featuring ACTR3

Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)
Category members Corum 27 Arp2/3 protein complex Database 0.04


Categories featuring ACTR3

Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)
Category members GO Category GO:0005515 protein binding Database INF
Category members GO Category GO:0005829 cytosol Database INF
Category members GO Category GO:0005737 cytoplasm Database 12.81
Category members GO Category GO:0005524 ATP binding Database 5.54
Category members GO Category GO:0003779 actin binding Database 5.41
Category members GO Category GO:0031252 cell leading edge Database 2.52
Category members GO Category GO:0015629 actin cytoskeleton Database 2.22
Category members Pathway Pathway_579 PID_ERBB1_DOWNSTREAM_PATHWAY 0 1.97
Category members GO Category GO:0030027 lamellipodium Database 1.77
Category members Pathway Pathway_309 ST_INTEGRIN_SIGNALING_PATHWAY 0 1.35
Category members Pathway Pathway_561 PID_PDGFRB_PATHWAY 0 1.18
Category members GO Category GO:0007163 establishment or maintenance of cell polarity Database 1.08
Category members Pathway Pathway_669 PID_RAC1_PATHWAY 0 0.68
Category members Pathway Pathway_568 PID_CDC42_PATHWAY 0 0.68
Category members Pathway Pathway_838 SIG_REGULATION_OF_THE_ACTIN_CYTOSKELETON_BY_RHO_GTPASES 0 0.35
Category members GO Category GO:0038096 Fc-gamma receptor signaling pathway involved in phagocytosis Database 0.33
Category members GO Category GO:0010592 positive regulation of lamellipodium assembly Database 0.31
Category members GO Category GO:0002102 podosome Database 0.3
Category members Pathway Pathway_667 BIOCARTA_RHO_PATHWAY 0 0.3
Category members Pathway Pathway_510 SIG_CHEMOTAXIS 0 0.28
Category members GO Category GO:0006928 cellular component movement Database 0.24
Category members GO Category GO:0051321 meiotic cell cycle Database 0.23
Category members GO Category GO:0030838 positive regulation of actin filament polymerization Database 0.21
Category members Pathway Pathway_615 BIOCARTA_CDC42RAC_PATHWAY 0 0.18
Category members GO Category GO:0050775 positive regulation of dendrite morphogenesis Database 0.15
Category members GO Category GO:0030056 hemidesmosome Database 0.1
Category members GO Category GO:0046677 response to antibiotic Database 0.08
Category members Pathway Pathway_236 BIOCARTA_MPR_PATHWAY 0 0.06
Category members GO Category GO:0008356 asymmetric cell division Database 0.05
Category members GO Category GO:0045087 innate immune response Database 0.05
Category members Pathway Pathway_1037 BIOCARTA_SALMONELLA_PATHWAY 0 0
Category members Pathway Pathway_912 BIOCARTA_ACTINY_PATHWAY 0 0
Category members GO Category GO:0000139 Golgi membrane Database 0
Category members GO Category GO:0005885 Arp2/3 protein complex Database 0
Category members GO Category GO:0009743 response to carbohydrate Database 0
Category members GO Category GO:0033206 meiotic cytokinesis Database 0
Category members GO Category GO:0045666 positive regulation of neuron differentiation Database 0
Category members GO Category GO:0051491 positive regulation of filopodium assembly Database 0
Category members GO Category GO:0051653 spindle localization Database 0
Category members GO Category GO:0060076 excitatory synapse Database 0
Category members GO Category GO:0060271 cilium morphogenesis Database 0


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