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Query: ACSL3

This is a cancer-associated gene according to the Sanger cancer gene census.

RNAi screen result RNAPII IP (PI) CSB IP CSB IP (PI) Chrom. Chrom. (PI) Phosphorylation Ubiquitylation
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[Click on the plots to view the data selection in the respective scatterplot]

Protein Results:

 Results for post-translational modifications: see below | Red/green: hit at lower/upper end of the respective screen
Gene name Point score Z-score sums RNAi high RNAi low RNAPII-IP (PI) CSB-IP CSB-IP (PI) Chrom. Chrom. (PI)
ACSL3 0 2.403 -1.350 2.060 0.010 0.425 -0.116 0.343 0.188

PTM Sites:

 Back to Protein Results | Red/green: hit at lower/upper end of the respective screen
Gene name PTM type PTM site UV UV (PI) Sequence
ACSL3 Ubiquitylation K8 0.466 _(ac)MNNHVSSK(gl)PSTMK_
ACSL3 Ubiquitylation K63 -0.973 -1.522 _AKPVNSK(gl)PDSAYR_

Background Information for ACSL3:


Pubmed-ACSL3 »
Uniprot-ACSL3 »
Biogrid-ACSL3 »
ProteomicsDB-ACSL3 »

Tumorportal-ACSL3 »
COSMIC-ACSL3 »
GenomeRNAi-ACSL3 »
Genecards-ACSL3


Protein-protein Interactions for ACSL3
Show screen data for Category Name and Description Link to cat description Data Source
Category members IP bait ACSL4 Cat. description Hein, Mann, Cell 2015
Category members IP bait CHEK1 Cat. description Hein, Mann, Cell 2015
Category members IP bait GET4 Cat. description Hein, Mann, Cell 2015
Category members IP bait KIF11 Cat. description Hein, Mann, Cell 2015
Category members IP bait KIF20B Cat. description Hein, Mann, Cell 2015
Category members IP bait RASSF1 Cat. description Hein, Mann, Cell 2015
Category members IP bait REEP5 Cat. description Hein, Mann, Cell 2015
Category members IP bait SKA1 Cat. description Hein, Mann, Cell 2015
Category members IP bait TIGD6 Cat. description Hein, Mann, Cell 2015
Category members IP bait GNAT2 Cat. description BioPlex, Huttlin, Gygi, Cell 2015


Protein Domains in ACSL3
Domain name Domain Description TC-NER relevance -log10(p-value)
Category members AMP-binding IPR020459 0.04
Category members AMP-dep_Synth/Lig IPR000873 0


Protein complexes (CORUM database) featuring ACSL3
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)


Categories featuring ACSL3
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)
Category members GO Category GO:0016021 integral to membrane Database 7.67
Category members GO Category GO:0005524 ATP binding Database 5.54
Category members Human mutations Sanger_cancer_genes Sanger cancer genes Database 4.88
Category members GO Category GO:0019904 protein domain specific binding Database 1.85
Category members GO Category GO:0005789 endoplasmic reticulum membrane Database 1.57
Category members GO Category GO:0005783 endoplasmic reticulum Database 0.62
Category members GO Category GO:0044539 long-chain fatty acid import Database 0.53
Category members GO Category GO:0005741 mitochondrial outer membrane Database 0.46
Category members GO Category GO:0048471 perinuclear region of cytoplasm Database 0.39
Category members GO Category GO:0019901 protein kinase binding Database 0.37
Category members Pathway Pathway_133 KEGG_FATTY_ACID_METABOLISM 0 0.31
Category members GO Category GO:0005794 Golgi apparatus Database 0.27
Category members Pathway Pathway_1 REACTOME_FATTY_ACID_TRIACYLGLYCEROL_AND_KETONE_BODY_METABOLISM 0 0.23
Category members Pathway Pathway_6 REACTOME_FATTY_ACYL_COA_BIOSYNTHESIS 0 0.2
Category members GO Category GO:0003824 catalytic activity Database 0.11
Category members Pathway Pathway_2 REACTOME_TRIGLYCERIDE_BIOSYNTHESIS 0 0.08
Category members Pathway Pathway_152 REACTOME_SYNTHESIS_OF_VERY_LONG_CHAIN_FATTY_ACYL_COAS 0 0.04
Category members GO Category GO:0005778 peroxisomal membrane Database 0.01
Category members Pathway Pathway_25 KEGG_PEROXISOME 0 0
Category members Pathway Pathway_4 REACTOME_METABOLISM_OF_LIPIDS_AND_LIPOPROTEINS 0 0
Category members Pathway Pathway_40 KEGG_ADIPOCYTOKINE_SIGNALING_PATHWAY 0 0
Category members Pathway Pathway_43 KEGG_PPAR_SIGNALING_PATHWAY 0 0
Category members GO Category GO:0001676 long-chain fatty acid metabolic process Database 0
Category members GO Category GO:0004467 long-chain fatty acid-CoA ligase activity Database 0
Category members GO Category GO:0005811 lipid particle Database 0
Category members GO Category GO:0006633 fatty acid biosynthetic process Database 0
Category members GO Category GO:0007420 brain development Database 0
Category members GO Category GO:0007584 response to nutrient Database 0
Category members GO Category GO:0008152 metabolic process Database 0
Category members GO Category GO:0014070 response to organic cyclic compound Database 0
Category members GO Category GO:0034379 very-low-density lipoprotein particle assembly Database 0
Category members GO Category GO:0042998 positive regulation of Golgi to plasma membrane protein transport Database 0
Category members GO Category GO:0051047 positive regulation of secretion Database 0


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