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Query: ACO1

This is a cancer-associated gene according to the Broad cancer gene census.

RNAi screen result RNAPII IP (PI) CSB IP CSB IP (PI) Chrom. Chrom. (PI) Phosphorylation Ubiquitylation
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[Click on the plots to view the data selection in the respective scatterplot]

Protein Results:

 Results for post-translational modifications: see below | Red/green: hit at lower/upper end of the respective screen
Gene name Point score Z-score sums RNAi high RNAi low RNAPII-IP (PI) CSB-IP CSB-IP (PI) Chrom. Chrom. (PI)
ACO1 1 3.694 -2.080 4.040

PTM Sites:

 Back to Protein Results | Red/green: hit at lower/upper end of the respective screen
Gene name PTM type PTM site UV UV (PI) Sequence
ACO1 Ubiquitylation K396 -0.346 _DFESCLGAK(gl)QGFK_
ACO1 Ubiquitylation K79 -0.349 _NIEVPFK(gl)PAR_

Background Information for ACO1:


Pubmed-ACO1 »
Uniprot-ACO1 »
Biogrid-ACO1 »
ProteomicsDB-ACO1 »

Tumorportal-ACO1 »
COSMIC-ACO1 »
GenomeRNAi-ACO1 »
Genecards-ACO1


Protein-protein Interactions for ACO1
Show screen data for Category Name and Description Link to cat description Data Source


Protein Domains in ACO1
Domain name Domain Description TC-NER relevance -log10(p-value)
Category members AconitaseA/IPMdHydase_ssu_swvl IPR000573 0
Category members Acoase/IPM_deHydtase_lsu_aba IPR001030 0
Category members Aconitase/Fe_reg_2 IPR006249 0
Category members Aconitase/3IPM_dehydase_swvl IPR015928 0


Protein complexes (CORUM database) featuring ACO1
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)


Categories featuring ACO1
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)
Category members GO Category GO:0003723 RNA binding Database INF
Category members GO Category GO:0005515 protein binding Database INF
Category members GO Category GO:0005829 cytosol Database INF
Category members GO Category GO:0005737 cytoplasm Database 12.81
Category members Pathway Pathway_3 KEGG_CITRATE_CYCLE_TCA_CYCLE 0 3.83
Category members GO Category GO:0006099 tricarboxylic acid cycle Database 2.74
Category members GO Category GO:0005739 mitochondrion Database 1.67
Category members Human mutations Broad_cancer_genes Broad cancer genes (Lawrence et al., 2014) literature 1.14
Category members GO Category GO:0005783 endoplasmic reticulum Database 0.62
Category members GO Category GO:0005794 Golgi apparatus Database 0.27
Category members GO Category GO:0003994 aconitate hydratase activity Database 0.17
Category members GO Category GO:0006101 citrate metabolic process Database 0.13
Category members Pathway Pathway_7 KEGG_GLYOXYLATE_AND_DICARBOXYLATE_METABOLISM 0 0.08
Category members GO Category GO:0006417 regulation of translation Database 0
Category members GO Category GO:0006879 cellular iron ion homeostasis Database 0
Category members GO Category GO:0008152 metabolic process Database 0
Category members GO Category GO:0009791 post-embryonic development Database 0
Category members GO Category GO:0010040 response to iron(II) ion Database 0
Category members GO Category GO:0010468 regulation of gene expression Database 0
Category members GO Category GO:0030350 iron-responsive element binding Database 0
Category members GO Category GO:0046872 metal ion binding Database 0
Category members GO Category GO:0050892 intestinal absorption Database 0
Category members GO Category GO:0051539 4 iron, 4 sulfur cluster binding Database 0


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