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Query: XPO1

This is a cancer-associated gene according to the Broad and Sanger cancer gene census.

RNAi screen result RNAPII IP (PI) CSB IP CSB IP (PI) Chrom. Chrom. (PI) Phosphorylation Ubiquitylation
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[Click on the plots to view the data selection in the respective scatterplot]

Protein Results:

 Results for post-translational modifications: see below | Red/green: hit at lower/upper end of the respective screen
Gene name Point score Z-score sums RNAi high RNAi low RNAPII-IP (PI) CSB-IP CSB-IP (PI) Chrom. Chrom. (PI)
XPO1 0 4.739 -0.520 0.800 0.240 1.064 0.205 0.673 0.522

PTM Sites:

 Back to Protein Results | Red/green: hit at lower/upper end of the respective screen
Gene name PTM type PTM site UV UV (PI) Sequence
XPO1 Ubiquitylation K455 0.519 0.708 _DTDSINLYK(gl)NM(ox)R_
XPO1 Ubiquitylation K693 0.285 0.582 _QLGSILK(gl)TNVR_
XPO1 Phosphorylation S391 -0.074 0.083 _ESPFSTSAS(ph)PLLSGSQHFDVPPR_
XPO1 Ubiquitylation K680 -0.376 _NVDILK(gl)DPETVK_
XPO1 Ubiquitylation K531 0.402 _DLLGLCEQK(gl)R_
XPO1 Ubiquitylation K700 -0.104 _ACK(gl)AVGHPFVIQLGR_

Background Information for XPO1:


Pubmed-XPO1 »
Uniprot-XPO1 »
Biogrid-XPO1 »
ProteomicsDB-XPO1 »

Tumorportal-XPO1 »
COSMIC-XPO1 »
GenomeRNAi-XPO1 »
Genecards-XPO1


Protein-protein Interactions for XPO1
Show screen data for Category Name and Description Link to cat description Data Source
Category members IP bait APC Cat. description Hein, Mann, Cell 2015
Category members IP bait ARMC6 Cat. description Hein, Mann, Cell 2015
Category members IP bait CCT3 Cat. description Hein, Mann, Cell 2015
Category members IP bait CNOT2 Cat. description Hein, Mann, Cell 2015
Category members IP bait JARID1C;KDM5C Cat. description Hein, Mann, Cell 2015
Category members IP bait L3MBTL3 Cat. description Hein, Mann, Cell 2015
Category members IP bait MAGEA10 Cat. description Hein, Mann, Cell 2015
Category members IP bait NABP1 Cat. description Hein, Mann, Cell 2015
Category members IP bait PPP4C Cat. description Hein, Mann, Cell 2015
Category members IP bait RAB5B Cat. description Hein, Mann, Cell 2015
Category members IP bait RCC1 Cat. description Hein, Mann, Cell 2015
Category members IP bait SKP1 Cat. description Hein, Mann, Cell 2015
Category members IP bait TERF1 Cat. description Hein, Mann, Cell 2015
Category members IP bait TUBGCP2 Cat. description Hein, Mann, Cell 2015
Category members IP bait XPO1 Cat. description Hein, Mann, Cell 2015
Category members IP bait YWHAZ Cat. description Hein, Mann, Cell 2015
Category members IP bait APLNR Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait LPAR4 Cat. description BioPlex, Huttlin, Gygi, Cell 2015


Protein Domains in XPO1
Domain name Domain Description TC-NER relevance -log10(p-value)
Category members ARM-type_fold IPR016024 9.26
Category members Importin-beta_N IPR001494 0
Category members Exportin-1/Importin-b-like IPR013598 0


Protein complexes (CORUM database) featuring XPO1
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)
Category members Corum 1176 CRM1-RAN-PHAX-CBC complex (cap binding complex) Database 0.57
Category members Corum 1045 Snurportin-CRM1-RanGTP complex Database 0.11
Category members Corum 1116 CRM1-Survivin-AuroraB mitotic complex Database 0.05
Category members Corum 1117 CRM1-Survivin mitotic complex Database 0


Categories featuring XPO1
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)
Category members Pathway Pathway_371 REACTOME_INFLUENZA_LIFE_CYCLE 0 INF
Category members Pathway Pathway_771 REACTOME_METABOLISM_OF_RNA 0 INF
Category members Pathway Pathway_773 REACTOME_METABOLISM_OF_MRNA 0 INF
Category members GO Category GO:0003723 RNA binding Database INF
Category members GO Category GO:0005515 protein binding Database INF
Category members GO Category GO:0005634 nucleus Database INF
Category members GO Category GO:0005654 nucleoplasm Database INF
Category members GO Category GO:0005829 cytosol Database INF
Category members GO Category GO:0010467 gene expression Database INF
Category members GO Category GO:0016032 viral process Database INF
Category members GO Category GO:0016070 RNA metabolic process Database INF
Category members GO Category GO:0016071 mRNA metabolic process Database INF
Category members GO Category GO:0019058 viral life cycle Database INF
Category members GO Category GO:0005730 nucleolus Database 13.38
Category members GO Category GO:0005737 cytoplasm Database 12.81
Category members Pathway Pathway_197 REACTOME_HIV_INFECTION 0 12.07
Category members Pathway Pathway_320 REACTOME_CELL_CYCLE 0 11.08
Category members GO Category GO:0000278 mitotic cell cycle Database 10.63
Category members Pathway Pathway_196 REACTOME_HOST_INTERACTIONS_OF_HIV_FACTORS 0 9.67
Category members Pathway Pathway_376 REACTOME_HIV_LIFE_CYCLE 0 9.45
Category members GO Category GO:0005488 binding Database 9.32
Category members GO Category GO:0030529 ribonucleoprotein complex Database 8.45
Category members GO Category GO:0019048 modulation by virus of host morphology or physiology Database 7.81
Category members Pathway Pathway_374 REACTOME_LATE_PHASE_OF_HIV_LIFE_CYCLE 0 7.57
Category members Pathway Pathway_1311 REACTOME_NEP_NS2_INTERACTS_WITH_THE_CELLULAR_EXPORT_MACHINERY 0 7.24
Category members GO Category GO:0005635 nuclear envelope Database 7.22
Category members Pathway Pathway_321 REACTOME_MITOTIC_M_M_G1_PHASES 0 5.47
Category members Pathway Pathway_323 REACTOME_DNA_REPLICATION 0 5.24
Category members Human mutations Sanger_cancer_genes Sanger cancer genes Database 4.88
Category members Pathway Pathway_317 REACTOME_CELL_CYCLE_MITOTIC 0 4.82
Category members GO Category GO:0006886 intracellular protein transport Database 2.48
Category members Pathway Pathway_726 REACTOME_MITOTIC_PROMETAPHASE 0 2.41
Category members GO Category GO:0000776 kinetochore Database 2.24
Category members Pathway Pathway_781 REACTOME_REGULATION_OF_MRNA_STABILITY_BY_PROTEINS_THAT_BIND_AU_RICH_ELEMENTS 0 2.04
Category members GO Category GO:0019904 protein domain specific binding Database 1.85
Category members Pathway Pathway_924 PID_ILK_PATHWAY 0 1.75
Category members GO Category GO:0051028 mRNA transport Database 1.7
Category members Pathway Pathway_1023 PID_NFAT_3PATHWAY 0 1.46
Category members Pathway Pathway_1254 PID_RANBP2_PATHWAY 0 1.33
Category members Human mutations Broad_cancer_genes Broad cancer genes (Lawrence et al., 2014) literature 1.14
Category members Pathway Pathway_943 PID_HDAC_CLASSI_PATHWAY 0 1.08
Category members Pathway Pathway_118 PID_FOXO_PATHWAY 0 0.97
Category members GO Category GO:0042176 regulation of protein catabolic process Database 0.91
Category members Pathway Pathway_777 REACTOME_SIGNALING_BY_TGF_BETA_RECEPTOR_COMPLEX 0 0.89
Category members GO Category GO:0042493 response to drug Database 0.66
Category members Pathway Pathway_199 PID_BETA_CATENIN_NUC_PATHWAY 0 0.53
Category members Pathway Pathway_727 REACTOME_MITOTIC_G2_G2_M_PHASES 0 0.46
Category members Pathway Pathway_1143 PID_HDAC_CLASSII_PATHWAY 0 0.3
Category members Pathway Pathway_794 REACTOME_TGF_BETA_RECEPTOR_SIGNALING_ACTIVATES_SMADS 0 0.29
Category members GO Category GO:0008565 protein transporter activity Database 0.26
Category members GO Category GO:0007179 transforming growth factor beta receptor signaling pathway Database 0.25
Category members Pathway Pathway_816 REACTOME_DOWNREGULATION_OF_TGF_BETA_RECEPTOR_SIGNALING 0 0.23
Category members GO Category GO:0008536 Ran GTPase binding Database 0.21
Category members GO Category GO:0034504 protein localization to nucleus Database 0.15
Category members GO Category GO:0046825 regulation of protein export from nucleus Database 0.11
Category members Pathway Pathway_984 PID_HEDGEHOG_GLI_PATHWAY 0 0.1
Category members GO Category GO:0010824 regulation of centrosome duplication Database 0.08
Category members Pathway Pathway_971 REACTOME_CYCLIN_A_B1_ASSOCIATED_EVENTS_DURING_G2_M_TRANSITION 0 0.06
Category members GO Category GO:0015030 Cajal body Database 0.04
Category members GO Category GO:0000122 negative regulation of transcription from RNA polymerase II promoter Database 0.02
Category members GO Category GO:0030512 negative regulation of transforming growth factor beta receptor signaling pathway Database 0.02
Category members Pathway Pathway_1051 PID_NFKAPPAB_CANONICAL_PATHWAY 0 0
Category members Pathway Pathway_969 BIOCARTA_PTC1_PATHWAY 0 0
Category members GO Category GO:0005215 transporter activity Database 0
Category members GO Category GO:0005642 annulate lamellae Database 0
Category members GO Category GO:0006611 protein export from nucleus Database 0


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