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Query: WDR5

RNAi screen result RNAPII IP (PI) CSB IP CSB IP (PI) Chrom. Chrom. (PI) Phosphorylation Ubiquitylation
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[Click on the plots to view the data selection in the respective scatterplot]

Protein Results:

 Results for post-translational modifications: see below | Red/green: hit at lower/upper end of the respective screen
Gene name Point score Z-score sums RNAi high RNAi low RNAPII-IP (PI) CSB-IP CSB-IP (PI) Chrom. Chrom. (PI)
WDR5 0 0.984 0.230 0.330 -0.088 -0.237 0.506 0.098 -0.100

PTM Sites:

 Back to Protein Results | Red/green: hit at lower/upper end of the respective screen
Gene name PTM type PTM site UV UV (PI) Sequence
WDR5 Ubiquitylation K27 -1.584 _AQPTPSSSATQSK(gl)PTPVKPNYALK_
WDR5 Ubiquitylation K32 -1.722 _AQPTPSSSATQSKPTPVK(gl)PNYALK_
WDR5 Ubiquitylation K120 0.445 _IWDVSSGK(gl)CLK_
WDR5 Ubiquitylation K245 0.475 _LWDYSK(gl)GK_
WDR5 Ubiquitylation K247 0.475 _LWDYSK(gl)GK_

Background Information for WDR5:


Pubmed-WDR5 »
Uniprot-WDR5 »
Biogrid-WDR5 »
ProteomicsDB-WDR5 »

Tumorportal-WDR5 »
COSMIC-WDR5 »
GenomeRNAi-WDR5 »
Genecards-WDR5


Protein-protein Interactions for WDR5
Show screen data for Category Name and Description Link to cat description Data Source
Category members IP bait BOD1 Cat. description Hein, Mann, Cell 2015
Category members IP bait CXXC1 Cat. description Hein, Mann, Cell 2015
Category members IP bait KAT8 Cat. description Hein, Mann, Cell 2015
Category members IP bait L3MBTL2 Cat. description Hein, Mann, Cell 2015
Category members IP bait PML Cat. description Hein, Mann, Cell 2015
Category members IP bait RING1 Cat. description Hein, Mann, Cell 2015
Category members IP bait SET Cat. description Hein, Mann, Cell 2015
Category members IP bait SETD1B Cat. description Hein, Mann, Cell 2015
Category members IP bait WDR5 Cat. description Hein, Mann, Cell 2015
Category members IP bait CCDC101 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait E2F6 Cat. description BioPlex, Huttlin, Gygi, Cell 2015


Protein Domains in WDR5
Domain name Domain Description TC-NER relevance -log10(p-value)
Category members WD40_repeat_dom IPR017986 1.39
Category members TIF_beta_prop-like IPR013979 1.21
Category members WD40_repeat IPR001680 0.52
Category members G-protein_beta_WD-40_rep IPR020472 0.12


Protein complexes (CORUM database) featuring WDR5
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)
Category members Corum 1257 ALL-1 supercomplex Database 4.3
Category members Corum 2721 HCF-1 complex Database 2.08
Category members Corum 2730 Set1B complex Database 1.09
Category members Corum 2731 Set1A complex Database 0.62
Category members Corum 1399 WDR5-ASH2L-RBBP5-MLL2 complex Database 0.47
Category members Corum 1254 Menin-associated histone methyltransferase complex Database 0.35
Category members Corum 5195 PTIP-HMT complex Database 0.33
Category members Corum 5386 MLL1-WDR5 complex Database 0.31
Category members Corum 1256 MLL-HCF complex Database 0.3
Category members Corum 1401 MOF complex Database 0.09
Category members Corum 3075 UTX-MLL2/3 complex Database 0


Categories featuring WDR5
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)
Category members GO Category GO:0005515 protein binding Database INF
Category members GO Category GO:0005634 nucleus Database INF
Category members GO Category GO:0051568 histone H3-K4 methylation Database 1.7
Category members GO Category GO:0006351 transcription, DNA-templated Database 1.07
Category members GO Category GO:0042800 histone methyltransferase activity (H3-K4 specific) Database 0.73
Category members GO Category GO:0048188 Set1C/COMPASS complex Database 0.64
Category members GO Category GO:0071339 MLL1 complex Database 0.45
Category members GO Category GO:0043981 histone H4-K5 acetylation Database 0.43
Category members GO Category GO:0043982 histone H4-K8 acetylation Database 0.43
Category members GO Category GO:0005622 intracellular Database 0.32
Category members GO Category GO:0035097 histone methyltransferase complex Database 0.26
Category members GO Category GO:0000123 histone acetyltransferase complex Database 0.15
Category members GO Category GO:0043984 histone H4-K16 acetylation Database 0.07
Category members GO Category GO:0043995 histone acetyltransferase activity (H4-K5 specific) Database 0.04
Category members GO Category GO:0043996 histone acetyltransferase activity (H4-K8 specific) Database 0.04
Category members GO Category GO:0046972 histone acetyltransferase activity (H4-K16 specific) Database 0.04
Category members Pathway Pathway_1249 PID_CIRCADIAN_PATHWAY 0 0
Category members GO Category GO:0001501 skeletal system development Database 0
Category members GO Category GO:0005671 Ada2/Gcn5/Ada3 transcription activator complex Database 0
Category members GO Category GO:0006355 regulation of transcription, DNA-dependent Database 0
Category members GO Category GO:0043966 histone H3 acetylation Database 0


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