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Query: VPS35

RNAi screen result RNAPII IP (PI) CSB IP CSB IP (PI) Chrom. Chrom. (PI) Phosphorylation Ubiquitylation
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[Click on the plots to view the data selection in the respective scatterplot]

Protein Results:

 Results for post-translational modifications: see below | Red/green: hit at lower/upper end of the respective screen
Gene name Point score Z-score sums RNAi high RNAi low RNAPII-IP (PI) CSB-IP CSB-IP (PI) Chrom. Chrom. (PI)
VPS35 0 0.393 -0.480 0.040
VPS35 0 0.393 -0.480 0.040 -0.214 0.370 -0.544 0.601 0.416

PTM Sites:

 Back to Protein Results | Red/green: hit at lower/upper end of the respective screen
Gene name PTM type PTM site UV UV (PI) Sequence
VPS35 Phosphorylation S7 0.322 _PTTQQS(ph)PQDEQEKLLDEAIQAVK_
VPS35 Ubiquitylation K659 -0.478 _TQCALAASK(gl)LLK_
VPS35 Phosphorylation T4 -0.120 _PTT(ph)QQSPQDEQEKLLDEAIQAVK_

Background Information for VPS35:


Pubmed-VPS35 »
Uniprot-VPS35 »
Biogrid-VPS35 »
ProteomicsDB-VPS35 »

Tumorportal-VPS35 »
COSMIC-VPS35 »
GenomeRNAi-VPS35 »
Genecards-VPS35


Protein-protein Interactions for VPS35
Show screen data for Category Name and Description Link to cat description Data Source
Category members IP bait VPS26A Cat. description Hein, Mann, Cell 2015
Category members IP bait VPS26B Cat. description Hein, Mann, Cell 2015
Category members IP bait MCM7 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait MRM1 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait VPS26A Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait VPS26B Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait VPS29 Cat. description BioPlex, Huttlin, Gygi, Cell 2015


Protein Domains in VPS35
Domain name Domain Description TC-NER relevance -log10(p-value)
Category members ARM-type_fold IPR016024 9.26


Protein complexes (CORUM database) featuring VPS35
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)
Category members Corum 1059 Retromer complex (SNX1, SNX2, VPS35, VPS29, VPS26A) Database 0
Category members Corum 1060 Retromer complex (SNX1, SNX2, VPS35, VPS29, VPS26B) Database 0
Category members Corum 656 VPS35-VPS29-VPS26A complex Database 0
Category members Corum 657 Retromer complex (SNX1, SNX2, VPS35, VPS29, VPS26A) Database 0


Categories featuring VPS35
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)
Category members GO Category GO:0005515 protein binding Database INF
Category members GO Category GO:0005829 cytosol Database INF
Category members GO Category GO:0005488 binding Database 9.32
Category members GO Category GO:0015031 protein transport Database 3.48
Category members GO Category GO:0005765 lysosomal membrane Database 0.82
Category members GO Category GO:0043231 intracellular membrane-bounded organelle Database 0.43
Category members GO Category GO:0005768 endosome Database 0.29
Category members GO Category GO:0042147 retrograde transport, endosome to Golgi Database 0.26
Category members GO Category GO:0030904 retromer complex Database 0.14
Category members GO Category GO:0008219 cell death Database 0.08
Category members Disease phenotype Young_adult-onset_Parkinsonism Young adult-onset Parkinsonism Database 0


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