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Query: USP14

RNAi screen result RNAPII IP (PI) CSB IP CSB IP (PI) Chrom. Chrom. (PI) Phosphorylation Ubiquitylation
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[Click on the plots to view the data selection in the respective scatterplot]

Protein Results:

 Results for post-translational modifications: see below | Red/green: hit at lower/upper end of the respective screen
Gene name Point score Z-score sums RNAi high RNAi low RNAPII-IP (PI) CSB-IP CSB-IP (PI) Chrom. Chrom. (PI)
USP14 1 7.243 -0.120 1.090
USP14 1 7.243 -0.120 1.090 -0.442 3.486

PTM Sites:

 Back to Protein Results | Red/green: hit at lower/upper end of the respective screen
Gene name PTM type PTM site UV UV (PI) Sequence
USP14 Ubiquitylation K54 -0.506 0.880 _GGTLK(gl)DDDWGNIK_
USP14 Phosphorylation S143 0.551 0.678 _AS(ph)GEM(ox)ASAQYITAALR_
USP14 Ubiquitylation K62 -1.110 0.317 _GGTLKDDDWGNIK(gl)IK_
USP14 Phosphorylation S394 0.259 _VNQQPNTSDKKSS(ph)PQK_
USP14 Ubiquitylation K313 -0.672 -0.343 _NALYIK(gl)SSK_
USP14 Ubiquitylation K441 0.293 -0.492 _SSSSGHYVSWVK(gl)R_
USP14 Ubiquitylation K291 -0.258 -0.581 _YLFTGLK(gl)_
USP14 Ubiquitylation K130 -0.994 -0.631 _SVPELK(gl)DALKR_
USP14 Ubiquitylation K134 -0.783 _SVPELKDALK(gl)R_
USP14 Ubiquitylation K300 -0.534 -1.071 _LQEEITK(gl)QSPTLQR_
USP14 Ubiquitylation K224 -1.522 -1.122 _LEAIEDDSVK(gl)ETDSSSASAATPSK_
USP14 Ubiquitylation K239 -0.850 _LEAIEDDSVKETDSSSASAATPSKK(gl)_
USP14 Ubiquitylation K336 1.000 _FFYK(gl)EKESVNAK_
USP14 Ubiquitylation K342 -0.361 _ESVNAK(gl)VLK_
USP14 Phosphorylation S389 -0.018 _VNQQPNTS(ph)DKKSSPQK_

Background Information for USP14:


Pubmed-USP14 »
Uniprot-USP14 »
Biogrid-USP14 »
ProteomicsDB-USP14 »

Tumorportal-USP14 »
COSMIC-USP14 »
GenomeRNAi-USP14 »
Genecards-USP14


Protein-protein Interactions for USP14
Show screen data for Category Name and Description Link to cat description Data Source
Category members IP bait PSMC1 Cat. description Hein, Mann, Cell 2015
Category members IP bait PSMD6 Cat. description Hein, Mann, Cell 2015
Category members IP bait USP14 Cat. description BioPlex, Huttlin, Gygi, Cell 2015


Protein Domains in USP14
Domain name Domain Description TC-NER relevance -log10(p-value)
Category members Ubiquitin-rel_dom IPR029071 1.79
Category members Ubiquitin-like IPR000626 1.61
Category members UCH/PAN2 IPR028889 0.62
Category members Peptidase_C19_UCH IPR001394 0.53


Protein complexes (CORUM database) featuring USP14
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)


Categories featuring USP14
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)
Category members GO Category GO:0005515 protein binding Database INF
Category members GO Category GO:0005737 cytoplasm Database 12.81
Category members GO Category GO:0006511 ubiquitin-dependent protein catabolic process Database 3.57
Category members GO Category GO:0004843 ubiquitin-specific protease activity Database 3.28
Category members GO Category GO:0000502 proteasome complex Database 3.17
Category members GO Category GO:0004221 ubiquitin thiolesterase activity Database 1.36
Category members GO Category GO:0005886 plasma membrane Database 1.21
Category members GO Category GO:0070628 proteasome binding Database 0.46
Category members GO Category GO:0004197 cysteine-type endopeptidase activity Database 0.38
Category members GO Category GO:0007268 synaptic transmission Database 0.23
Category members GO Category GO:0009986 cell surface Database 0.17
Category members GO Category GO:0016023 cytoplasmic membrane-bounded vesicle Database 0.17
Category members GO Category GO:0045202 synapse Database 0.06
Category members GO Category GO:0010951 negative regulation of endopeptidase activity Database 0
Category members GO Category GO:0004866 endopeptidase inhibitor activity Database 0
Category members GO Category GO:0008193 tRNA guanylyltransferase activity Database 0
Category members GO Category GO:0008234 cysteine-type peptidase activity Database 0
Category members GO Category GO:0050920 regulation of chemotaxis Database 0
Category members GO Category GO:0061136 regulation of proteasomal protein catabolic process Database 0


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