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bioLOGIC Data

Query: USF2

RNAi screen result	RNAPII IP (PI)	CSB IP	CSB IP (PI)	Chrom.	Chrom. (PI)	Phosphorylation	Ubiquitylation
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[Click on the plots to view the data selection in the respective scatterplot]

Protein Results:
Results for post-translational modifications: see below | Red/green: hit at lower/upper end of the respective screen

Gene name	Point score	Z-score sums	RNAi high	RNAi low	RNAPII-IP (PI)	CSB-IP	CSB-IP (PI)	Chrom.	Chrom. (PI)
USF2	1	6.720	0.080	-0.210		0.151	-0.093
USF2	1	6.720	0.080	-0.210				0.695	4.891

PTM Sites:
Back to Protein Results | Red/green: hit at lower/upper end of the respective screen

Gene name	PTM type	PTM site	UV	UV (PI)	Sequence
USF2	Phosphorylation	S279	-0.121	0.837	_GGILS(ph)KACDYIR_
USF2	Ubiquitylation	K269	-0.265	0.440	_IIPDCNADNSK(gl)TGASK_
USF2	Ubiquitylation	K300	-0.172		_MQETFK(gl)EAER_

Background Information for USF2:

Pubmed-USF2 »

Uniprot-USF2 »

Biogrid-USF2 »

ProteomicsDB-USF2 »

Tumorportal-USF2 »

COSMIC-USF2 »

GenomeRNAi-USF2 »

Genecards-USF2

Protein-protein Interactions for USF2

Show screen data for	Category Name and Description	Link to cat description	Data Source
Category members	IP bait USF1;usf1	Cat. description	Hein, Mann, Cell 2015
Category members	IP bait ADAMTS12	Cat. description	BioPlex, Huttlin, Gygi, Cell 2015
Category members	IP bait CCDC102B	Cat. description	BioPlex, Huttlin, Gygi, Cell 2015
Category members	IP bait FOSL2	Cat. description	BioPlex, Huttlin, Gygi, Cell 2015
Category members	IP bait USF1	Cat. description	BioPlex, Huttlin, Gygi, Cell 2015

Protein Domains in USF2

	Domain name	Domain Description	TC-NER relevance -log10(p-value)
Category members	bHLH_dom	IPR011598	0.32

Protein complexes (CORUM database) featuring USF2

	Category Type	Category ID	Category Name	Data Source	TC-NER relevance -log10(p-value)

Categories featuring USF2

	Category Type	Category ID	Category Name	Data Source	TC-NER relevance -log10(p-value)
Category members	GO Category	GO:0005515	protein binding	Database	INF
Category members	GO Category	GO:0005634	nucleus	Database	INF
Category members	GO Category	GO:0003677	DNA binding	Database	1.53
Category members	GO Category	GO:0006351	transcription, DNA-templated	Database	1.07
Category members	GO Category	GO:0003690	double-stranded DNA binding	Database	0.66
Category members	GO Category	GO:0003700	sequence-specific DNA binding transcription factor activity	Database	0.63
Category members	GO Category	GO:0045893	positive regulation of transcription, DNA-dependent	Database	0.28
Category members	GO Category	GO:0046982	protein heterodimerization activity	Database	0.28
Category members	GO Category	GO:0006357	regulation of transcription from RNA polymerase II promoter	Database	0.19
Category members	GO Category	GO:0043565	sequence-specific DNA binding	Database	0.18
Category members	GO Category	GO:0045944	positive regulation of transcription from RNA polymerase II promoter	Database	0.13
Category members	Pathway	Pathway_440	PID_FRA_PATHWAY	0	0
Category members	GO Category	GO:0000430	regulation of transcription from RNA polymerase II promoter by glucose	Database	0
Category members	GO Category	GO:0000432	positive regulation of transcription from RNA polymerase II promoter by glucose	Database	0
Category members	GO Category	GO:0000978	RNA polymerase II core promoter proximal region sequence-specific DNA binding	Database	0
Category members	GO Category	GO:0003705	RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity	Database	0
Category members	GO Category	GO:0007595	lactation	Database	0
Category members	GO Category	GO:0019086	late viral transcription	Database	0
Category members	GO Category	GO:0042803	protein homodimerization activity	Database	0
Category members	GO Category	GO:0043425	bHLH transcription factor binding	Database	0
Category members	GO Category	GO:0046983	protein dimerization activity	Database	0
Category members	GO Category	GO:0055088	lipid homeostasis	Database	0