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Query: UCHL5

RNAi screen result RNAPII IP (PI) CSB IP CSB IP (PI) Chrom. Chrom. (PI) Phosphorylation Ubiquitylation
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[Click on the plots to view the data selection in the respective scatterplot]

Protein Results:

 Results for post-translational modifications: see below | Red/green: hit at lower/upper end of the respective screen
Gene name Point score Z-score sums RNAi high RNAi low RNAPII-IP (PI) CSB-IP CSB-IP (PI) Chrom. Chrom. (PI)
UCHL5 1 2.360 0.080 0.070
UCHL5 1 2.360 0.080 0.070 0.053 -0.539 0.136

PTM Sites:

 Back to Protein Results | Red/green: hit at lower/upper end of the respective screen
Gene name PTM type PTM site UV UV (PI) Sequence
UCHL5 Ubiquitylation K317 -0.037 0.724 _TLAEHQQLIPLVEKAK(gl)_
UCHL5 Ubiquitylation K210 -0.599 0.531 _RIQK(gl)YSEGEIR_
UCHL5 Ubiquitylation K154 0.112 0.468 _QQMFEFDTK(gl)TSAK_
UCHL5 Ubiquitylation K234 0.086 0.335 _MIYEQK(gl)IAELQR_
UCHL5 Ubiquitylation K279 1.986 0.052 _NQMLIEEEVQKLK(gl)_
UCHL5 Ubiquitylation K277 0.914 _NQMLIEEEVQK(gl)LKR_
UCHL5 Ubiquitylation K315 -0.307 _TLAEHQQLIPLVEK(gl)AK_

Background Information for UCHL5:


Pubmed-UCHL5 »
Uniprot-UCHL5 »
Biogrid-UCHL5 »
ProteomicsDB-UCHL5 »

Tumorportal-UCHL5 »
COSMIC-UCHL5 »
GenomeRNAi-UCHL5 »
Genecards-UCHL5


Protein-protein Interactions for UCHL5
Show screen data for Category Name and Description Link to cat description Data Source
Category members IP bait ACTR5 Cat. description Hein, Mann, Cell 2015
Category members IP bait PSMC1 Cat. description Hein, Mann, Cell 2015
Category members IP bait PSMD14 Cat. description Hein, Mann, Cell 2015
Category members IP bait PSMD6 Cat. description Hein, Mann, Cell 2015
Category members IP bait RUVBL1 Cat. description Hein, Mann, Cell 2015
Category members IP bait RUVBL2 Cat. description Hein, Mann, Cell 2015
Category members IP bait CCDC74B Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait KDELR1 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait PSMD7 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait SLC17A2 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait UCHL5 Cat. description BioPlex, Huttlin, Gygi, Cell 2015


Protein Domains in UCHL5
Domain name Domain Description TC-NER relevance -log10(p-value)
Category members Peptidase_C12_UCH IPR001578 0.35


Protein complexes (CORUM database) featuring UCHL5
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)


Categories featuring UCHL5
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)
Category members GO Category GO:0005515 protein binding Database INF
Category members GO Category GO:0005634 nucleus Database INF
Category members GO Category GO:0005829 cytosol Database INF
Category members GO Category GO:0006281 DNA repair Database INF
Category members GO Category GO:0005737 cytoplasm Database 12.81
Category members GO Category GO:0006511 ubiquitin-dependent protein catabolic process Database 3.57
Category members GO Category GO:0004843 ubiquitin-specific protease activity Database 3.28
Category members GO Category GO:0000502 proteasome complex Database 3.17
Category members GO Category GO:0006310 DNA recombination Database 3.14
Category members GO Category GO:0004221 ubiquitin thiolesterase activity Database 1.36
Category members GO Category GO:0016579 protein deubiquitination Database 1.32
Category members GO Category GO:0006351 transcription, DNA-templated Database 1.07
Category members Pathway Pathway_777 REACTOME_SIGNALING_BY_TGF_BETA_RECEPTOR_COMPLEX 0 0.89
Category members GO Category GO:0070628 proteasome binding Database 0.46
Category members GO Category GO:0005622 intracellular Database 0.32
Category members Pathway Pathway_794 REACTOME_TGF_BETA_RECEPTOR_SIGNALING_ACTIVATES_SMADS 0 0.29
Category members GO Category GO:0031011 Ino80 complex Database 0.29
Category members GO Category GO:0008242 omega peptidase activity Database 0.28
Category members GO Category GO:0007179 transforming growth factor beta receptor signaling pathway Database 0.25
Category members Pathway Pathway_816 REACTOME_DOWNREGULATION_OF_TGF_BETA_RECEPTOR_SIGNALING 0 0.23
Category members GO Category GO:0048853 forebrain morphogenesis Database 0.04
Category members GO Category GO:0030512 negative regulation of transforming growth factor beta receptor signaling pathway Database 0.02
Category members GO Category GO:0010951 negative regulation of endopeptidase activity Database 0
Category members GO Category GO:0004866 endopeptidase inhibitor activity Database 0
Category members GO Category GO:0006355 regulation of transcription, DNA-dependent Database 0
Category members GO Category GO:0021670 lateral ventricle development Database 0
Category members GO Category GO:0030901 midbrain development Database 0
Category members GO Category GO:0061136 regulation of proteasomal protein catabolic process Database 0


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