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Query: UBE2E1

RNAi screen result RNAPII IP (PI) CSB IP CSB IP (PI) Chrom. Chrom. (PI) Phosphorylation Ubiquitylation
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[Click on the plots to view the data selection in the respective scatterplot]

Protein Results:

 Results for post-translational modifications: see below | Red/green: hit at lower/upper end of the respective screen
Gene name Point score Z-score sums RNAi high RNAi low RNAPII-IP (PI) CSB-IP CSB-IP (PI) Chrom. Chrom. (PI)
UBE2E1 0 -0.008 1.580 -0.610 -0.786 -0.414

PTM Sites:

 Back to Protein Results | Red/green: hit at lower/upper end of the respective screen
Gene name PTM type PTM site UV UV (PI) Sequence
UBE2E1 Ubiquitylation K43 0.668 0.523 _NSK(gl)LLSTSAK_
UBE2E1 Ubiquitylation K50 0.531 _LLSTSAK(gl)R_
UBE2E1 Ubiquitylation K54 -1.325 _IQK(gl)ELADITLDPPPNCSAGPK_

Background Information for UBE2E1:


Pubmed-UBE2E1 »
Uniprot-UBE2E1 »
Biogrid-UBE2E1 »
ProteomicsDB-UBE2E1 »

Tumorportal-UBE2E1 »
COSMIC-UBE2E1 »
GenomeRNAi-UBE2E1 »
Genecards-UBE2E1


Protein-protein Interactions for UBE2E1
Show screen data for Category Name and Description Link to cat description Data Source
Category members IP bait DET1 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait ID2 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait MBD5 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait RNF25 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait SIK1 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait TRIB1 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait TRIB2 Cat. description BioPlex, Huttlin, Gygi, Cell 2015


Protein Domains in UBE2E1
Domain name Domain Description TC-NER relevance -log10(p-value)
Category members UBQ-conjugat_E2 IPR000608 0
Category members UBQ-conjugating_enzyme/RWD IPR016135 0


Protein complexes (CORUM database) featuring UBE2E1
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)
Category members Corum 1165 RNF20-RNF40-UbE2E1 complex Database 0.21


Categories featuring UBE2E1
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)
Category members GO Category GO:0005515 protein binding Database INF
Category members GO Category GO:0005634 nucleus Database INF
Category members GO Category GO:0005654 nucleoplasm Database INF
Category members GO Category GO:0005829 cytosol Database INF
Category members Pathway Pathway_320 REACTOME_CELL_CYCLE 0 11.08
Category members GO Category GO:0000278 mitotic cell cycle Database 10.63
Category members GO Category GO:0005524 ATP binding Database 5.54
Category members Pathway Pathway_317 REACTOME_CELL_CYCLE_MITOTIC 0 4.82
Category members Pathway Pathway_621 REACTOME_ADAPTIVE_IMMUNE_SYSTEM 0 4.72
Category members Pathway Pathway_790 REACTOME_CELL_CYCLE_CHECKPOINTS 0 3.89
Category members GO Category GO:0006511 ubiquitin-dependent protein catabolic process Database 3.57
Category members Pathway Pathway_689 REACTOME_ANTIVIRAL_MECHANISM_BY_IFN_STIMULATED_GENES 0 3.51
Category members GO Category GO:0051437 positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle Database 3.38
Category members GO Category GO:0051436 negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle Database 3.35
Category members GO Category GO:0051439 regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle Database 3.26
Category members Pathway Pathway_827 REACTOME_AUTODEGRADATION_OF_CDH1_BY_CDH1_APC_C 0 3.01
Category members Pathway Pathway_458 REACTOME_IMMUNE_SYSTEM 0 3
Category members GO Category GO:0031145 anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process Database 2.59
Category members Pathway Pathway_764 REACTOME_CLASS_I_MHC_MEDIATED_ANTIGEN_PROCESSING_PRESENTATION 0 2.56
Category members Pathway Pathway_780 REACTOME_APC_C_CDH1_MEDIATED_DEGRADATION_OF_CDC20_AND_OTHER_APC_C_CDH1_TARGETED_PROTEINS_IN_LATE_MITOSIS_EARLY_G1 0 2.46
Category members GO Category GO:0000209 protein polyubiquitination Database 2.46
Category members Pathway Pathway_784 REACTOME_APC_C_CDC20_MEDIATED_DEGRADATION_OF_MITOTIC_PROTEINS 0 2.26
Category members Pathway Pathway_888 KEGG_UBIQUITIN_MEDIATED_PROTEOLYSIS 0 2.22
Category members Pathway Pathway_788 REACTOME_REGULATION_OF_MITOTIC_CELL_CYCLE 0 1.91
Category members Pathway Pathway_832 REACTOME_ANTIGEN_PROCESSING_UBIQUITINATION_PROTEASOME_DEGRADATION 0 1.58
Category members Pathway Pathway_836 REACTOME_APC_CDC20_MEDIATED_DEGRADATION_OF_NEK2A 0 1.58
Category members GO Category GO:0010390 histone monoubiquitination Database 1.39
Category members Pathway Pathway_818 REACTOME_APC_C_CDC20_MEDIATED_DEGRADATION_OF_CYCLIN_B 0 1.37
Category members Pathway Pathway_1247 REACTOME_CONVERSION_FROM_APC_C_CDC20_TO_APC_C_CDH1_IN_LATE_ANAPHASE 0 1.09
Category members Pathway Pathway_1245 REACTOME_PHOSPHORYLATION_OF_THE_APC_C 0 1.06
Category members Pathway Pathway_1246 REACTOME_INHIBITION_OF_THE_PROTEOLYTIC_ACTIVITY_OF_APC_C_REQUIRED_FOR_THE_ONSET_OF_ANAPHASE_BY_MITOTIC_SPINDLE_CHECKPOINT_COMPONENTS 0 0.98
Category members Pathway Pathway_699 REACTOME_INTERFERON_SIGNALING 0 0.86
Category members GO Category GO:0033523 histone H2B ubiquitination Database 0.77
Category members GO Category GO:0007094 mitotic spindle assembly checkpoint Database 0.68
Category members GO Category GO:0019221 cytokine-mediated signaling pathway Database 0.44
Category members Pathway Pathway_505 REACTOME_CYTOKINE_SIGNALING_IN_IMMUNE_SYSTEM 0 0.33
Category members GO Category GO:0000151 ubiquitin ligase complex Database 0.24
Category members GO Category GO:0004842 ubiquitin-protein ligase activity Database 0.24
Category members GO Category GO:0016567 protein ubiquitination Database 0.07
Category members GO Category GO:0016881 acid-amino acid ligase activity Database 0
Category members GO Category GO:0032020 ISG15-protein conjugation Database 0
Category members GO Category GO:0042296 ISG15 ligase activity Database 0
Category members GO Category GO:0070936 protein K48-linked ubiquitination Database 0


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