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Query: TUSC3

RNAi screen result RNAPII IP (PI) CSB IP CSB IP (PI) Chrom. Chrom. (PI) Phosphorylation Ubiquitylation
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[Click on the plots to view the data selection in the respective scatterplot]

Protein Results:

 Results for post-translational modifications: see below | Red/green: hit at lower/upper end of the respective screen
Gene name Point score Z-score sums RNAi high RNAi low RNAPII-IP (PI) CSB-IP CSB-IP (PI) Chrom. Chrom. (PI)
TUSC3 0 -0.120 0.700 -0.570

PTM Sites:

 Back to Protein Results | Red/green: hit at lower/upper end of the respective screen
Gene name PTM type PTM site UV UV (PI) Sequence
TUSC3 Ubiquitylation K72 -0.120 _MNGDK(gl)FR_
TUSC3 Ubiquitylation K78 -0.759 _FIK(gl)APPR_

Background Information for TUSC3:


Pubmed-TUSC3 »
Uniprot-TUSC3 »
Biogrid-TUSC3 »
ProteomicsDB-TUSC3 »

Tumorportal-TUSC3 »
COSMIC-TUSC3 »
GenomeRNAi-TUSC3 »
Genecards-TUSC3


Protein-protein Interactions for TUSC3
Show screen data for Category Name and Description Link to cat description Data Source
Category members IP bait C19orf46 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait CHRND Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait GABRA3 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait GABRD Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait HTR3A Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait HTR3C Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait MCOLN3 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait RNF185 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait SCN3B Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait TUSC3 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait UPK1A Cat. description BioPlex, Huttlin, Gygi, Cell 2015


Protein Domains in TUSC3
Domain name Domain Description TC-NER relevance -log10(p-value)
Category members Thioredoxin_domain IPR013766 0.49
Category members Thioredoxin-like_fold IPR012336 0.16
Category members OligosaccharylTrfase_OST3/OST6 IPR021149 0


Protein complexes (CORUM database) featuring TUSC3
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)
Category members Corum 1200 Oligosaccharyltransferase complex (Stt3B variant) Database 0.78


Categories featuring TUSC3
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)
Category members Pathway Pathway_11 REACTOME_METABOLISM_OF_PROTEINS 0 12.01
Category members GO Category GO:0044267 cellular protein metabolic process Database 10.42
Category members GO Category GO:0005887 integral to plasma membrane Database 1.69
Category members GO Category GO:0005739 mitochondrion Database 1.67
Category members GO Category GO:0005789 endoplasmic reticulum membrane Database 1.57
Category members GO Category GO:0004579 dolichyl-diphosphooligosaccharide-protein glycotransferase activity Database 0.38
Category members GO Category GO:0008250 oligosaccharyltransferase complex Database 0.33
Category members GO Category GO:0050890 cognition Database 0.11
Category members GO Category GO:0045454 cell redox homeostasis Database 0.05
Category members Pathway Pathway_109 KEGG_N_GLYCAN_BIOSYNTHESIS 0 0.04
Category members Pathway Pathway_94 REACTOME_POST_TRANSLATIONAL_PROTEIN_MODIFICATION 0 0
Category members Pathway Pathway_95 REACTOME_ASPARAGINE_N_LINKED_GLYCOSYLATION 0 0
Category members Disease phenotype Autosomal_recessive_non-syndromic_intellectual_disability Autosomal recessive non-syndromic intellectual disability Database 0
Category members GO Category GO:0006487 protein N-linked glycosylation Database 0
Category members GO Category GO:0015095 magnesium ion transmembrane transporter activity Database 0
Category members GO Category GO:0015693 magnesium ion transport Database 0
Category members GO Category GO:0018279 protein N-linked glycosylation via asparagine Database 0
Category members GO Category GO:0043687 post-translational protein modification Database 0


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