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Query: TPM4

This is a cancer-associated gene according to the Sanger cancer gene census.

RNAi screen result RNAPII IP (PI) CSB IP CSB IP (PI) Chrom. Chrom. (PI) Phosphorylation Ubiquitylation
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[Click on the plots to view the data selection in the respective scatterplot]

Protein Results:

 Results for post-translational modifications: see below | Red/green: hit at lower/upper end of the respective screen
Gene name Point score Z-score sums RNAi high RNAi low RNAPII-IP (PI) CSB-IP CSB-IP (PI) Chrom. Chrom. (PI)
TPM4 0 1.442 1.200 0.010 -0.178 0.366 -0.380 0.330 -1.062

PTM Sites:

 Back to Protein Results | Red/green: hit at lower/upper end of the respective screen
Gene name PTM type PTM site UV UV (PI) Sequence
TPM4 Ubiquitylation K11 0.368 1.125 _(ac)AGITTIEAVK(gl)R_
TPM4 Ubiquitylation K228 1.242 0.668 _CTK(gl)EEHLCTQR_
TPM4 Ubiquitylation K116 -0.031 _MELQEIQLKEAK(gl)_
TPM4 Ubiquitylation K223 0.612 _TIDDLEDK(gl)LK_
TPM4 Ubiquitylation K225 0.564 _TIDDLEDKLK(gl)CTK_

Background Information for TPM4:


Pubmed-TPM4 »
Uniprot-TPM4 »
Biogrid-TPM4 »
ProteomicsDB-TPM4 »

Tumorportal-TPM4 »
COSMIC-TPM4 »
GenomeRNAi-TPM4 »
Genecards-TPM4


Protein-protein Interactions for TPM4
Show screen data for Category Name and Description Link to cat description Data Source
Category members IP bait ACTB Cat. description Hein, Mann, Cell 2015
Category members IP bait ADD1 Cat. description Hein, Mann, Cell 2015
Category members IP bait ANAPC13 Cat. description Hein, Mann, Cell 2015
Category members IP bait ANLN Cat. description Hein, Mann, Cell 2015
Category members IP bait CALML3 Cat. description Hein, Mann, Cell 2015
Category members IP bait CAPZA2 Cat. description Hein, Mann, Cell 2015
Category members IP bait CDK2 Cat. description Hein, Mann, Cell 2015
Category members IP bait DCTN3 Cat. description Hein, Mann, Cell 2015
Category members IP bait FLNA Cat. description Hein, Mann, Cell 2015
Category members IP bait FLOT1 Cat. description Hein, Mann, Cell 2015
Category members IP bait IQGAP1 Cat. description Hein, Mann, Cell 2015
Category members IP bait KIAA1279 Cat. description Hein, Mann, Cell 2015
Category members IP bait KIAA1430 Cat. description Hein, Mann, Cell 2015
Category members IP bait MAPRE1 Cat. description Hein, Mann, Cell 2015
Category members IP bait MAST3 Cat. description Hein, Mann, Cell 2015
Category members IP bait MYH10 Cat. description Hein, Mann, Cell 2015
Category members IP bait MYH9 Cat. description Hein, Mann, Cell 2015
Category members IP bait MYO18A Cat. description Hein, Mann, Cell 2015
Category members IP bait MYO19 Cat. description Hein, Mann, Cell 2015
Category members IP bait MYO1C Cat. description Hein, Mann, Cell 2015
Category members IP bait PDLIM7 Cat. description Hein, Mann, Cell 2015
Category members IP bait PPP1CB Cat. description Hein, Mann, Cell 2015
Category members IP bait PPP1CC Cat. description Hein, Mann, Cell 2015
Category members IP bait RAB5C Cat. description Hein, Mann, Cell 2015
Category members IP bait SLC33A1 Cat. description Hein, Mann, Cell 2015
Category members IP bait TBCK Cat. description Hein, Mann, Cell 2015
Category members IP bait TPM1 Cat. description Hein, Mann, Cell 2015
Category members IP bait TPM4 Cat. description Hein, Mann, Cell 2015
Category members IP bait USO1 Cat. description Hein, Mann, Cell 2015
Category members IP bait TPM1 Cat. description BioPlex, Huttlin, Gygi, Cell 2015


Protein Domains in TPM4
Domain name Domain Description TC-NER relevance -log10(p-value)
Category members Tropomyosin IPR000533 0.08


Protein complexes (CORUM database) featuring TPM4
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)


Categories featuring TPM4
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)
Category members GO Category GO:0005829 cytosol Database INF
Category members DDR Literature pubmedid:24055347 Jungmichel et al., 2013 UV-stimulated poly(ADP-Ribosyl)ation targets Jungmichel et al., 2013 INF
Category members GO Category GO:0005737 cytoplasm Database 12.81
Category members GO Category GO:0003779 actin binding Database 5.41
Category members Human mutations Sanger_cancer_genes Sanger cancer genes Database 4.88
Category members GO Category GO:0005856 cytoskeleton Database 0.63
Category members GO Category GO:0002102 podosome Database 0.3
Category members GO Category GO:0006928 cellular component movement Database 0.24
Category members GO Category GO:0030863 cortical cytoskeleton Database 0.24
Category members Disease phenotype Inflammatory_myofibroblastic_tumor Inflammatory myofibroblastic tumor Database 0.23
Category members GO Category GO:0005509 calcium ion binding Database 0.11
Category members GO Category GO:0001725 stress fiber Database 0.04
Category members GO Category GO:0031941 filamentous actin Database 0.01
Category members Pathway Pathway_1008 KEGG_HYPERTROPHIC_CARDIOMYOPATHY_HCM 0 0
Category members Pathway Pathway_1208 REACTOME_STRIATED_MUSCLE_CONTRACTION 0 0
Category members Pathway Pathway_198 KEGG_CARDIAC_MUSCLE_CONTRACTION 0 0
Category members Pathway Pathway_262 KEGG_DILATED_CARDIOMYOPATHY 0 0
Category members Pathway Pathway_949 REACTOME_SMOOTH_MUSCLE_CONTRACTION 0 0
Category members Pathway Pathway_950 REACTOME_MUSCLE_CONTRACTION 0 0
Category members GO Category GO:0005862 muscle thin filament tropomyosin Database 0
Category members GO Category GO:0006936 muscle contraction Database 0
Category members GO Category GO:0008307 structural constituent of muscle Database 0
Category members GO Category GO:0030049 muscle filament sliding Database 0


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